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> Protein (NX_P10124)
Protein (NX_P10124)
Protein
Gene SymbolSRGN to neXtProt (NX_P10124)
DescriptionSerglycin
Chromosome10
Location10q22.1 (70847862 ~ 70864567) to Ensembl
Sequene Features : Isoforms 1, Variants 26, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cytokine secretion
.maintenance of granzyme B location in T cell secretory granule
.maintenance of protease location in mast cell secretory granule
  + 9 more...
.N/A .mast cell granule
.zymogen granule
.platelet alpha granule lumen
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 26 9
2014-09-19protein level
1 23 9
2014-05-27protein level
1 23 9
2014-02-25protein level
1 23 9
2013-12-09protein level
1 19 9
2013-11-01protein level
1 18 9
2013-09-12protein level
1 18 9
2013-08-17protein level
1 18 9
2013-07-15protein level
1 16 9
2013-06-11protein level
1 16 9
2013-02-12protein level
1 12 9
2012-12-20protein level
1 12 9
2012-10-30protein level
1 9 9
2012-10-07protein level
1 9 9
2012-08-24protein level
1 8 9
2012-07-28protein level
1 8 9
2012-06-08protein level
1 9 9
2012-05-07protein level
1 7 9
2012-04-10protein level
1 7 9
2012-01-13protein level
1 7 9
2011-12-20protein level
1 7 9
2011-11-11protein level
1 7 9
2011-08-23protein level
1 7 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P10124-1
5 0 0 17640.5875
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-744915,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
2 EBI-744915,EBI-2505785 GZMB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.natural killer cell mediated cytotoxicity
  + 7 more...
.serine-type peptidase activity
.serine-type endopeptidase activity
.intracellular membrane-bounded organelle
.membrane
.cytosol
  + 3 more...
3 EBI-744915,EBI-741480 UBQLN1  
  .regulation of autophagic vacuole assembly
.positive regulation of ER-associated ubiquitin-dependent protein catabolic process
.regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
  + 8 more...
.identical protein binding
.polyubiquitin binding
.kinase binding
.perinuclear region of cytoplasm
.protein complex
.aggresome
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland121
ascites25
blood621
bone223
bone marrow389
brain33
connective tissue154
ear62
embryonic tissue14
eye52
heart22
intestine17
kidney75
liver107
lung253
lymph node200
mammary gland26
mouth15
muscle18
nerve64
ovary49
pancreas79
parathyroid194
pharynx294
pituitary gland181
placenta84
prostate21
skin61
spleen93
stomach52
testis13
tonsil293
uterus56
vascular3891
Health State
TissuesTPM*
normal94
adrenal tumor237
bladder carcinoma170
breast (mammary gland) tumor32
chondrosarcoma350
gastrointestinal tumor16
germ cell tumor22
glioma83
head and neck tumor7
leukemia613
liver tumor156
lung tumor301
lymphoma138
non-neoplasia62
ovarian tumor26
pancreatic tumor95
primitive neuroectodermal tumor of the CNS7
prostate cancer19
skin tumor23
soft tissue/muscle tissue tumor31
uterine tumor33
Developmental Stage
TissuesTPM*
adult103
embryoid body42
fetus39
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue264
adrenal gland115.1
appendix673.5
bone marrow2311.6
cerebral cortex43.7
colon99.6
duodenum73.8
esophagus95
gallbladder298.8
heart muscle47.6
kidney52.9
liver98.5
lung191.7
lymph node366.2
ovary22.2
pancreas33
placenta225.2
prostate45.4
salivary gland27.1
skin13.6
small intestine105.2
spleen266.5
stomach94.4
testis25.6
thyroid gland59.3
urinary bladder288.2
Tissues
TissuesExpression level
appendixMedium
bone marrowHigh
hippocampusHigh
lungMedium
lymph nodeMedium
salivary glandHigh
skin 1Medium
spleenHigh
tonsilMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*177040, gene) Serglycin; SRGNOMIM


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