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> Protein (NX_P10275)
Protein (NX_P10275)
Protein
Gene SymbolAR to neXtProt (NX_P10275)
DescriptionAndrogen receptor
ChromosomeX
LocationXq12 (66764465 ~ 66950461) to Ensembl
Sequene Features : Isoforms 2, Variants 275, PTMs 18 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 275 18
2014-09-19protein level
2 265 18
2014-05-27protein level
2 265 18
2014-02-25protein level
2 264 18
2013-12-09protein level
2 262 18
2013-11-01protein level
2 258 18
2013-09-12protein level
2 258 18
2013-08-17protein level
2 258 18
2013-07-15protein level
2 245 18
2013-06-11protein level
2 245 18
2013-02-12protein level
2 228 25
2012-12-20protein level
2 228 25
2012-10-30protein level
2 228 25
2012-10-07protein level
2 228 20
2012-08-24protein level
2 228 20
2012-07-28protein level
2 228 20
2012-06-08protein level
2 247 20
2012-05-07protein level
2 247 20
2012-04-10protein level
2 247 20
2012-01-13protein level
2 247 20
2011-12-20protein level
2 260 20
2011-11-11protein level
2 260 20
2011-08-23protein level
2 259 18
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P10275-1
23 14 0 98925.1497
NX_P10275-2
1 14 0 44613.3971
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-608057,EBI-346930 PIK3R2  
  .regulation of small GTPase mediated signal transduction
.leukocyte migration
.T cell receptor signaling pathway
  + 25 more...
.protein heterodimerization activity
.1-phosphatidylinositol-3-kinase regulator activity
.receptor tyrosine kinase binding
.protein phosphatase binding
.phosphatidylinositol 3-kinase complex
.cytosol
.nucleus
2 EBI-608057,EBI-3929549 SOCS6  
  .negative regulation of T cell activation
.negative regulation of JAK-STAT cascade
.regulation of growth
  + 6 more...
.protein kinase inhibitor activity .cytoplasm
.immunological synapse
3 EBI-608057,EBI-2802973 CTDSP2  
  .negative regulation of G1/S transition of mitotic cell cycle
.cellular protein metabolic process
.IRE1-mediated unfolded protein response
  + 3 more...
.metal ion binding
.CTD phosphatase activity
.nucleoplasm
4 EBI-608057,EBI-3923013 SH2D1B  
  .positive regulation of innate immune response
.positive regulation of natural killer cell mediated immunity
.leukocyte activation involved in immune response
.protein binding, bridging .intracellular
5 EBI-608057,EBI-1384248 INPPL1  
  .ruffle assembly
.phosphatidylinositol dephosphorylation
.small molecule metabolic process
  + 13 more...
.SH2 domain binding
.hydrolase activity
.filopodium
.lamellipodium
.plasma membrane
  + 4 more...
6 EBI-608057,EBI-1759806 FOXH1  
  .negative regulation of androgen receptor activity
.nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
.negative regulation of androgen receptor signaling pathway
  + 14 more...
.R-SMAD binding
.co-SMAD binding
.androgen receptor binding
  + 11 more...
.activin responsive factor complex
.transcription factor complex
.nucleoplasm
  + 2 more...
7 EBI-608057,EBI-473199 KAT7  
  .histone H4-K12 acetylation
.histone H4-K8 acetylation
.histone H4-K5 acetylation
  + 5 more...
.zinc ion binding
.histone acetyltransferase activity
.sequence-specific DNA binding transcription factor activity
.cytoplasm
.nucleoplasm
.histone acetyltransferase complex
8 EBI-608057,EBI-2693298 WHSC1  
  .regulation of double-strand break repair via nonhomologous end joining
.regulation of establishment of protein localization
.bone development
  + 10 more...
.sequence-specific DNA binding
.histone-lysine N-methyltransferase activity
.zinc ion binding
.chromatin binding
.cytoplasm
.chromosome
.nucleoplasm
.nucleus
9 EBI-608057,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
10 EBI-608057,EBI-1348 LCK  
  .positive regulation of intrinsic apoptotic signaling pathway
.cellular response to peptide hormone stimulus
.positive regulation of uterine smooth muscle contraction
  + 35 more...
.ATPase binding
.phosphatidylinositol 3-kinase binding
.identical protein binding
  + 12 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 6 more...
11 EBI-608057,EBI-1220791 KLK3  
  .cellular protein metabolic process
.negative regulation of angiogenesis
.small GTPase mediated signal transduction
.serine-type peptidase activity
.serine-type endopeptidase activity
.extracellular exosome
.nucleus
.extracellular region
12 EBI-608057,EBI-1055635 FES  
  .positive regulation of actin cytoskeleton reorganization
.regulation of cell motility
.regulation of vesicle-mediated transport
  + 19 more...
.phosphatidylinositol binding
.immunoglobulin receptor binding
.ATP binding
  + 2 more...
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasmic membrane-bounded vesicle
.microtubule cytoskeleton
  + 4 more...
13 EBI-608057,EBI-515331 YES1  
  .cellular response to peptide hormone stimulus
.leukocyte migration
.ephrin receptor signaling pathway
  + 13 more...
.ion channel binding
.enzyme binding
.ATP binding
  + 3 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.focal adhesion
  + 6 more...
14 EBI-608057,EBI-79452 LYN  
  .positive regulation of dendritic cell apoptotic process
.negative regulation of intracellular signal transduction
.dendritic cell differentiation
  + 83 more...
.ion channel binding
.glycosphingolipid binding
.enzyme binding
  + 5 more...
.extracellular exosome
.perinuclear region of cytoplasm
.membrane raft
  + 11 more...
15 EBI-608057,EBI-1383732 FGR  
  .cellular response to peptide hormone stimulus
.defense response to Gram-positive bacterium
.regulation of phagocytosis
  + 22 more...
.Fc-gamma receptor I complex binding
.immunoglobulin receptor binding
.protein kinase binding
  + 4 more...
.extracellular exosome
.ruffle membrane
.extrinsic component of cytoplasmic side of plasma membrane
  + 5 more...
16 EBI-608057,EBI-79704 ERG  
  .cell differentiation
.cell proliferation
.multicellular organismal development
  + 4 more...
.sequence-specific DNA binding
.signal transducer activity
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.ribonucleoprotein complex
.cytoplasm
.nucleus
17 EBI-608057,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
18 EBI-608057,EBI-617403 PLCG2  
  .release of sequestered calcium ion into cytosol
.B cell receptor signaling pathway
.T cell receptor signaling pathway
  + 19 more...
.signal transducer activity
.phospholipase C activity
.phosphatidylinositol phospholipase C activity
.extracellular exosome
.plasma membrane
.cytosol
19 EBI-608057,EBI-2682803 JUND  
  .cellular response to calcium ion
.regulation of cell cycle
.response to cAMP
  + 18 more...
.transcription regulatory region DNA binding
.enzyme binding
.transcription factor binding
  + 4 more...
.transcription factor complex
.nucleoplasm
.nucleus
  + 2 more...
20 EBI-608057,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
21 EBI-608057,EBI-1632155 DDC  
  .cellular response to growth factor stimulus
.cellular response to alkaloid
.phytoalexin metabolic process
  + 13 more...
.L-dopa decarboxylase activity
.pyridoxal phosphate binding
.enzyme binding
  + 2 more...
.extracellular exosome
.neuronal cell body
.axon
  + 2 more...
22 EBI-608057,EBI-3911321 MAK  
  .protein autophosphorylation
.photoreceptor cell maintenance
.cell differentiation
  + 5 more...
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.protein kinase activity
.transcription coactivator activity
.mitotic spindle
.midbody
.centrosome
  + 4 more...
23 EBI-608057,EBI-1026476 RASA1  
  .regulation of RNA metabolic process
.blood vessel morphogenesis
.ephrin receptor signaling pathway
  + 14 more...
.GTPase binding
.potassium channel inhibitor activity
.receptor binding
  + 2 more...
.intrinsic component of the cytoplasmic side of the plasma membrane
.cytosol
.cytoplasm
.ruffle
24 EBI-608057,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
25 EBI-608057,EBI-78835 SHC1  
  .leukocyte migration
.neurotrophin TRK receptor signaling pathway
.positive regulation of DNA replication
  + 22 more...
.ephrin receptor binding
.protein kinase binding
.phospholipid binding
  + 6 more...
.Shc-EGFR complex
.plasma membrane
.cytosol
.mitochondrial matrix
26 EBI-608057,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
27 EBI-608057,EBI-751664 MATK  
  .innate immune response
.regulation of cell proliferation
.peptidyl-tyrosine autophosphorylation
  + 8 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytosol
28 EBI-608057,EBI-2105445 BLK  
  .cellular response to peptide hormone stimulus
.B cell receptor signaling pathway
.innate immune response
  + 6 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
29 EBI-608057,EBI-308629 HDAC4  
  .histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.actomyosin
.A band
.neuromuscular junction
  + 7 more...
30 EBI-608057,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
31 EBI-608057,EBI-1047576 BTG2  
  .negative regulation of neural precursor cell proliferation
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
.response to electrical stimulus
  + 15 more...
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription .extracellular exosome
32 EBI-608057,EBI-389668 MDM2  
  .negative regulation of signal transduction by p53 class mediator
.cellular response to UV-C
.cellular response to hypoxia
  + 44 more...
.ubiquitin protein ligase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 5 more...
.synapse
.protein complex
.endocytic vesicle membrane
  + 6 more...
33 EBI-608057,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
34 EBI-608057,EBI-353193 PRDX1  
  .hydrogen peroxide catabolic process
.regulation of NF-kappaB import into nucleus
.natural killer cell mediated cytotoxicity
  + 9 more...
.poly(A) RNA binding
.heme binding
.thioredoxin peroxidase activity
.peroxidase activity
.extracellular exosome
.melanosome
.cytosol
  + 7 more...
35 EBI-608057,EBI-970191 GRB7  
  .leukocyte migration
.stress granule assembly
.positive regulation of cell migration
  + 4 more...
.identical protein binding
.phosphatidylinositol binding
.protein kinase binding
  + 2 more...
.cell projection
.cytoplasmic stress granule
.focal adhesion
  + 2 more...
36 EBI-608057,EBI-78670 NCOA6  
  .labyrinthine layer blood vessel development
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 14 more...
.thyroid hormone receptor binding
.retinoid X receptor binding
.ligand-dependent nuclear receptor transcription coactivator activity
  + 4 more...
.intracellular membrane-bounded organelle
.histone methyltransferase complex
.transcription factor complex
  + 2 more...
37 EBI-608057,EBI-81236 NCOA2  
  .positive regulation of transcription from RNA polymerase II promoter
.small molecule metabolic process
.cellular lipid metabolic process
  + 11 more...
.nuclear hormone receptor binding
.thyroid hormone receptor coactivator activity
.ligand-dependent nuclear receptor transcription coactivator activity
  + 5 more...
.cytoplasm
.nucleoplasm
.nucleus
38 EBI-608057,EBI-1224969 JMJD1C  
  .chromatin modification
.blood coagulation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.dioxygenase activity
.thyroid hormone receptor binding
.metal ion binding
.nucleoplasm
.intracellular
39 EBI-608057,EBI-1567153 SMAD1  
  .positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus
.cellular response to BMP stimulus
.positive regulation of cartilage development
  + 28 more...
.I-SMAD binding
.co-SMAD binding
.metal ion binding
  + 8 more...
.protein complex
.integral component of membrane
.cytosol
  + 6 more...
40 EBI-608057,EBI-447269 HIF1A  
  .negative regulation of mesenchymal cell apoptotic process
.negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.dopaminergic neuron differentiation
  + 62 more...
.Hsp90 protein binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 12 more...
.RNA polymerase II transcription factor complex
.motile cilium
.nuclear speck
  + 6 more...
41 EBI-608057,EBI-2867186 IFI16  
  .negative regulation of cysteine-type endopeptidase activity
.activation of cysteine-type endopeptidase activity
.intrinsic apoptotic signaling pathway by p53 class mediator
  + 23 more...
.poly(A) RNA binding
.identical protein binding
.transcription factor binding
  + 4 more...
.nuclear speck
.membrane
.cytosol
  + 4 more...
42 EBI-608057,EBI-3956977 SHE  
  .N/A .N/A .N/A
43 EBI-608057,EBI-9453524 SHC4  
  .stem cell differentiation
.intracellular signal transduction
.regulation of gene expression
  + 3 more...
.receptor tyrosine kinase binding
.protein kinase binding
.postsynaptic membrane
.cell junction
.plasma membrane
44 EBI-608057,EBI-2623522 BLNK  
  .intracellular signal transduction
.B cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity
.transmembrane receptor protein tyrosine kinase adaptor activity
.plasma membrane
.cytosol
.cytoplasm
.intracellular
45 EBI-608057,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
46 EBI-608057,EBI-81215 CREBBP  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.cellular response to hypoxia
  + 27 more...
.MRF binding
.acetyltransferase activity
.zinc ion binding
  + 14 more...
.nuclear body
.cytoplasm
.transcription factor complex
  + 5 more...
47 EBI-608057,EBI-1164361 PARK7  
  .negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of androgen receptor activity
  + 69 more...
.glyoxalase (glycolic acid-forming) activity
.ubiquitin-specific protease binding
.cuprous ion binding
  + 24 more...
.extracellular exosome
.membrane raft
.cell body
  + 10 more...
48 EBI-608057,EBI-3389814 TNS1  
  .fibroblast migration
.cell-substrate junction assembly
.poly(A) RNA binding .cell surface
.focal adhesion
.cytoskeleton
.cytoplasm
49 EBI-608057,EBI-490630 SH2D2A  
  .vascular endothelial growth factor receptor signaling pathway
.cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity .cytosol
.cytoplasm
50 EBI-608057,EBI-2130308 RNF14  
  .regulation of androgen receptor signaling pathway
.positive regulation of transcription, DNA-templated
.response to estradiol
  + 6 more...
.androgen receptor binding
.ubiquitin-like protein transferase activity
.ligase activity
  + 2 more...
.cytoplasm
.nucleus
51 EBI-608057,EBI-77321 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
52 EBI-608057,EBI-6083058 STAP1  
  .positive regulation of actin cytoskeleton reorganization
.positive regulation of non-membrane spanning protein tyrosine kinase activity
.positive regulation of microglial cell activation
  + 10 more...
.protein kinase binding
.phospholipid binding
.SH3/SH2 adaptor activity
  + 2 more...
.protein complex
.mitochondrion
.cytoplasm
.nucleus
53 EBI-608057,EBI-2341483 RNF6  
  .protein K6-linked ubiquitination
.protein K48-linked ubiquitination
.regulation of androgen receptor signaling pathway
  + 5 more...
.androgen receptor binding
.ligase activity
.zinc ion binding
  + 2 more...
.intracellular membrane-bounded organelle
.nuclear membrane
.axon
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone41
brain6
ear62
embryonic tissue9
eye4
heart22
kidney23
larynx42
liver24
lung11
mammary gland19
muscle9
nerve64
ovary29
pancreas14
pituitary gland60
prostate89
skin4
testis27
uterus25
vascular19
Health State
TissuesTPM*
normal18
breast (mammary gland) tumor10
germ cell tumor3
glioma27
head and neck tumor7
non-neoplasia20
ovarian tumor13
pancreatic tumor28
prostate cancer96
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult20
embryoid body14
fetus32
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.2
adrenal gland1.2
colon1
esophagus1.7
gallbladder3
heart muscle7.8
kidney3.7
liver24.6
lung2
ovary19.1
prostate17.1
skin5.3
spleen1.1
testis5.1
thyroid gland2.7
urinary bladder3.7
Tissues
TissuesExpression level
breastMedium
cervix, uterineLow
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusLow
fallopian tubeMedium
seminal vesicleHigh
skin 1Medium
skin 2Medium
testisMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#300068, phenotype) Androgen insensitivity syndrome; AISOMIM
2(#312300, phenotype) Androgen insensitivity, partial; PAISOMIM
3(#313200, phenotype) Spinal and bulbar muscular atrophy, x-linked 1; SMAX1OMIM
4(*313700, gene) Androgen receptor; AROMIM


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