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> Protein (NX_P10415)
Protein (NX_P10415)
Protein
Gene SymbolBCL2 to neXtProt (NX_P10415)
DescriptionApoptosis regulator Bcl-2
Chromosome18
Location18q21.33 (60790579 ~ 60987361) to Ensembl
Sequene Features : Isoforms 2, Variants 111, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 111 more...
.BH3 domain binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 6 more...
.pore complex
.myelin sheath
.nuclear membrane
  + 8 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 111 3
2014-09-19protein level
2 102 3
2014-05-27protein level
2 102 3
2014-02-25protein level
2 87 3
2013-12-09protein level
2 87 3
2013-11-01protein level
2 87 3
2013-09-12protein level
2 87 3
2013-08-17protein level
2 87 3
2013-07-15protein level
2 87 3
2013-06-11protein level
2 87 3
2013-02-12protein level
2 87 6
2012-12-20protein level
2 87 6
2012-10-30protein level
2 87 6
2012-10-07protein level
2 87 3
2012-08-24protein level
2 6 3
2012-07-28protein level
2 6 3
2012-06-08protein level
2 16 3
2012-05-07protein level
2 16 3
2012-04-10protein level
2 16 3
2012-01-13protein level
2 16 3
2011-12-20protein level
2 16 1
2011-11-11protein level
2 16 1
2011-08-23protein level
2 16 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P10415-1
2 7 0 26249.0908
NX_P10415-2
1 7 0 22323.0349
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-77694,EBI-398437 MDM4  
  .cellular response to hypoxia
.negative regulation of cell cycle arrest
.protein stabilization
  + 9 more...
.enzyme binding
.zinc ion binding
.nucleoplasm
.nucleus
2 EBI-77694,EBI-520756 SIVA1  
  .positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
  + 3 more...
.metal ion binding
.zinc ion binding
.CD27 receptor binding
.virus receptor activity
.mitochondrion
.cytoplasm
.nucleoplasm
.nucleus
3 EBI-77694,EBI-526406 BCL2L11  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of fibroblast apoptotic process
.positive regulation of IRE1-mediated unfolded protein response
  + 42 more...
.N/A .BIM-BCL-2 complex
.BIM-BCL-xl complex
.extrinsic component of membrane
  + 3 more...
4 EBI-77694,EBI-849893 BNIP3L  
  .mitochondrial outer membrane permeabilization
.defense response to virus
.negative regulation of apoptotic process
  + 3 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
.lamin binding
.intrinsic component of membrane
.integral component of membrane
.endoplasmic reticulum
  + 3 more...
5 EBI-77694,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
6 EBI-77694,EBI-721550 NR4A1  
  .phosphatidylinositol-mediated signaling
.neurotrophin TRK receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 13 more...
.sequence-specific DNA binding
.zinc ion binding
.ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 2 more...
.nuclear membrane
.cytoplasm
.nucleoplasm
.nucleus
7 EBI-77694,EBI-349905 BRCA1  
  .positive regulation of histone H4-K16 acetylation
.positive regulation of histone H3-K9 acetylation
.negative regulation of reactive oxygen species metabolic process
  + 51 more...
.androgen receptor binding
.transcription regulatory region DNA binding
.ubiquitin protein ligase binding
  + 9 more...
.BRCA1-A complex
.protein complex
.BRCA1-BARD1 complex
  + 9 more...
8 EBI-77694,EBI-77683 BCAP31  
  .positive regulation of intrinsic apoptotic signaling pathway
.protein localization to endoplasmic reticulum exit site
.positive regulation of mitochondrial calcium ion concentration
  + 11 more...
.N/A .integral component of lumenal side of endoplasmic reticulum membrane
.endoplasmic reticulum-Golgi intermediate compartment membrane
.Golgi cisterna membrane
  + 7 more...
9 EBI-77694,EBI-519672 BID  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway
.regulation of G1/S transition of mitotic cell cycle
  + 24 more...
.death receptor binding .extracellular exosome
.integral component of mitochondrial membrane
.membrane
  + 3 more...
10 EBI-77694,EBI-516580 BAX  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of apoptotic signaling pathway
  + 87 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.BAX complex
.Bcl-2 family protein complex
.extracellular exosome
  + 10 more...
11 EBI-77694,EBI-700794 BIK  
  .positive regulation of release of cytochrome c from mitochondria
.positive regulation of protein homooligomerization
.apoptotic mitochondrial changes
  + 3 more...
.N/A .mitochondrial membrane
.integral component of membrane
.endomembrane system
12 EBI-77694,EBI-77642 TP53BP2  
  .positive regulation of execution phase of apoptosis
.intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of cell cycle
  + 7 more...
.NF-kappaB binding
.identical protein binding
.SH3/SH2 adaptor activity
.p53 binding
.perinuclear region of cytoplasm
.cytoplasm
.nucleus
13 EBI-77694,EBI-707392 PMAIP1  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 27 more...
.N/A .cytosol
.mitochondrial outer membrane
.mitochondrion
.nucleus
14 EBI-77694,EBI-949378 BECN1  
  .positive regulation of mitochondrion degradation
.positive regulation of attachment of mitotic spindle microtubules to kinetochore
.activation of mitophagy in response to mitochondrial depolarization
  + 28 more...
.phosphatidylinositol 3-kinase binding .phagocytic vesicle
.phosphatidylinositol 3-kinase complex, class III
.phosphatidylinositol 3-kinase complex, class III, type II
  + 12 more...
15 EBI-4370304,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
16 EBI-77694,EBI-700771 BAD  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of type B pancreatic cell development
.positive regulation of neuron death
  + 58 more...
.protein kinase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
.lipid binding
.phospholipid binding
.cytosol
.mitochondrial outer membrane
.mitochondrion
17 EBI-77694,EBI-2515597 NAF1  
  .ribosome biogenesis
.rRNA processing
.pseudouridine synthesis
.poly(A) RNA binding
.RNA binding
.cytoplasm
.small nucleolar ribonucleoprotein complex
.nucleus
18 EBI-77694,EBI-519884 BBC3  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of cysteine-type endopeptidase activity
.positive regulation of IRE1-mediated unfolded protein response
  + 21 more...
.N/A .cytosol
.mitochondrial outer membrane
.mitochondrion
19 EBI-77694,EBI-1220518 NLRP1  
  .neuron apoptotic process
.regulation of inflammatory response
.positive regulation of interleukin-1 beta secretion
  + 6 more...
.protein domain specific binding
.enzyme binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
.ATP binding
.NLRP1 inflammasome complex
.cytosol
.nucleus
.intracellular
20 EBI-77694,EBI-2512975 AMBRA1  
  .regulation of autophagic vacuole assembly
.positive regulation of mitochondrion degradation
.activation of mitophagy in response to mitochondrial depolarization
  + 6 more...
.ubiquitin protein ligase binding .phagocytic vesicle
.intracellular membrane-bounded organelle
.axoneme
  + 5 more...
21 EBI-77694,EBI-437804 BCLAF1  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of response to DNA damage stimulus
.positive regulation of DNA-templated transcription, initiation
  + 5 more...
.poly(A) RNA binding
.DNA binding
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood57
bone13
bone marrow20
brain14
connective tissue20
embryonic tissue4
eye14
heart44
intestine8
kidney61
lung23
lymph225
lymph node55
mammary gland19
mouth15
muscle18
nerve64
ovary59
parathyroid97
pituitary gland60
placenta56
prostate21
skin52
stomach73
testis11
thymus12
thyroid64
uterus8
vascular38
Health State
TissuesTPM*
normal27
breast (mammary gland) tumor32
chondrosarcoma24
colorectal tumor8
gastrointestinal tumor8
germ cell tumor64
glioma9
head and neck tumor22
kidney tumor14
leukemia105
lymphoma138
non-neoplasia51
ovarian tumor78
prostate cancer9
retinoblastoma43
skin tumor23
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult29
fetus30
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue15.6
adrenal gland3.1
appendix12.6
bone marrow4.6
cerebral cortex7.2
colon8.2
duodenum6.1
esophagus7.5
gallbladder7.2
heart muscle7.8
kidney9.7
liver2
lung4
lymph node18.3
ovary21.1
pancreas2.5
placenta10.1
prostate8.2
salivary gland2.9
skin5.7
small intestine5.6
spleen22.6
stomach5.7
testis2.4
thyroid gland54.9
urinary bladder6.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(+151430, gene/phenotype) B-cell cll/lymphoma 2; BCL2OMIM
2non-Hodgkin lymphoma;chronic lymphatic leukemiaCGP


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