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> Protein (NX_P10451)
Protein (NX_P10451)
Protein
Gene SymbolSPP1 to neXtProt (NX_P10451)
DescriptionOsteopontin
Chromosome4
Location4q22.1 (88896819 ~ 88904562) to Ensembl
Sequene Features : Isoforms 5, Variants 56, PTMs 44 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of collateral sprouting of intact axon in response to injury
.response to steroid hormone
.decidualization
  + 11 more...
.extracellular matrix binding .extracellular exosome
.perinuclear region of cytoplasm
.apical part of cell
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 56 44
2014-09-19protein level
5 46 44
2014-05-27protein level
5 46 44
2014-02-25protein level
5 46 44
2013-12-09protein level
5 37 44
2013-11-01protein level
5 35 44
2013-09-12protein level
5 35 43
2013-08-17protein level
5 35 43
2013-07-15protein level
5 22 43
2013-06-11protein level
5 22 43
2013-02-12protein level
5 16 194
2012-12-20protein level
5 15 194
2012-10-30protein level
5 17 194
2012-10-07protein level
5 17 41
2012-08-24protein level
5 15 41
2012-07-28protein level
5 15 41
2012-06-08protein level
5 18 41
2012-05-07protein level
5 17 41
2012-04-10protein level
4 17 41
2012-01-13protein level
4 12 41
2011-12-20protein level
4 12 41
2011-11-11protein level
4 12 41
2011-08-23protein level
4 12 41
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P10451-1
0 12 0 35401.1424
NX_P10451-2
1 11 0 33823.4509
NX_P10451-3
1 10 0 32335.5899
NX_P10451-4
1 11 0 32996.2949
NX_P10451-5
1 11 0 33822.4668
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-723648,EBI-347996 SGTA  
  .viral process .N/A .cytoplasm
2 EBI-723648,EBI-490245 CD44  
  .negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.positive regulation of monocyte aggregation
.monocyte aggregation
  + 27 more...
.hyaluronic acid binding
.collagen binding
.hyalurononglucosaminidase activity
.extracellular exosome
.macrophage migration inhibitory factor receptor complex
.basolateral plasma membrane
  + 7 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland151
bladder200
blood302
bone516
bone marrow205
brain650
cervix41
connective tissue53
ear1801
embryonic tissue408
esophagus49
eye282
heart78
intestine38
kidney1750
larynx468
liver194
lung238
lymph node11
mammary gland92
mouth60
muscle37
nerve193
ovary118
pancreas599
pharynx122
placenta1088
prostate15
skin123
spleen18
stomach94
testis50
thymus12
thyroid21
trachea57
umbilical cord145
uterus142
vascular38
Health State
TissuesTPM*
normal437
adrenal tumor395
bladder carcinoma398
breast (mammary gland) tumor85
cervical tumor57
chondrosarcoma169
colorectal tumor53
esophageal tumor57
gastrointestinal tumor75
germ cell tumor110
glioma158
head and neck tumor119
kidney tumor2265
leukemia137
liver tumor343
lung tumor632
lymphoma13
non-neoplasia393
ovarian tumor131
pancreatic tumor361
primitive neuroectodermal tumor of the CNS15
prostate cancer9
skin tumor191
soft tissue/muscle tissue tumor111
uterine tumor321
Developmental Stage
TissuesTPM*
adult360
embryoid body643
blastocyst48
neonate386
fetus236
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue19.1
adrenal gland26.3
appendix64
cerebral cortex368.3
colon10.2
duodenum7.4
esophagus6.7
gallbladder1837.1
heart muscle8.3
kidney1251.2
liver20.7
lung7.3
lymph node8.9
ovary2.3
pancreas61
placenta1425.9
prostate9.1
salivary gland4.5
small intestine8
spleen5.2
stomach8.9
testis16.6
thyroid gland7.6
urinary bladder25.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*166490, gene) Secreted phosphoprotein 1; SPP1OMIM


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