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> Protein (NX_P10599)
Protein (NX_P10599)
Protein
Gene SymbolTXN to neXtProt (NX_P10599)
DescriptionThioredoxin
Chromosome9
Location9q31.3 (113006091 ~ 113018920) to Ensembl
Sequene Features : Isoforms 2, Variants 8, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of hydrogen peroxide-induced cell death
.oxidation-reduction process
.nucleobase-containing small molecule metabolic process
  + 23 more...
.poly(A) RNA binding
.oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
.peptide disulfide oxidoreductase activity
.protein disulfide oxidoreductase activity
.extracellular exosome
.cytosol
.mitochondrion
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 8 12
2014-09-19protein level
2 7 12
2014-05-27protein level
2 7 12
2014-02-25protein level
2 7 9
2013-12-09protein level
2 3 9
2013-11-01protein level
2 3 8
2013-09-12protein level
2 3 8
2013-08-17protein level
2 3 8
2013-07-15protein level
2 1 8
2013-06-11protein level
2 1 8
2013-02-12protein level
1 0 9
2012-12-20protein level
1 0 9
2012-10-30protein level
1 1 9
2012-10-07protein level
1 1 9
2012-08-24protein level
1 1 9
2012-07-28protein level
1 1 9
2012-06-08protein level
1 13 9
2012-05-07protein level
1 13 9
2012-04-10protein level
1 13 9
2012-01-13protein level
1 14 9
2011-12-20protein level
1 14 9
2011-11-11protein level
1 14 9
2011-08-23protein level
1 14 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P10599-1
2 5 0 11729.7096
NX_P10599-2
1 5 0 9445.6587
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-594644,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
2 EBI-594644,EBI-968788 PTPN1  
  .positive regulation of receptor catabolic process
.peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
.negative regulation of PERK-mediated unfolded protein response
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.receptor tyrosine kinase binding
  + 4 more...
.cytoplasmic side of endoplasmic reticulum membrane
.sorting endosome
.cytoplasmic vesicle
  + 3 more...
3 EBI-594644,EBI-594661 COPS5  
  .exosomal secretion
.regulation of IRE1-mediated unfolded protein response
.regulation of cell cycle
  + 8 more...
.metal ion binding
.metallopeptidase activity
.ubiquitin-specific protease activity
  + 2 more...
.perinuclear region of cytoplasm
.cell junction
.COP9 signalosome
  + 5 more...
4 EBI-594644,EBI-476263 MAP3K5  
  .cellular response to reactive nitrogen species
.positive regulation of neuron death
.programmed necrotic cell death
  + 18 more...
.protein homodimerization activity
.protein phosphatase binding
.cysteine-type endopeptidase activator activity involved in apoptotic process
  + 4 more...
.IRE1-TRAF2-ASK1 complex
.protein kinase complex
.cytosol
5 EBI-594644,EBI-447677 MYD88  
  .cellular response to mechanical stimulus
.3'-UTR-mediated mRNA stabilization
.response to interleukin-1
  + 22 more...
.TIR domain binding
.identical protein binding
.death receptor binding
.endosome membrane
.plasma membrane
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
ascites225
bladder167
blood147
bone153
bone marrow471
brain52
cervix103
connective tissue382
ear310
embryonic tissue140
eye67
heart323
intestine189
kidney90
liver467
lung137
lymph90
lymph node33
mammary gland52
mouth75
muscle84
nerve128
ovary19
pancreas74
parathyroid242
pharynx171
placenta74
prostate147
salivary gland148
skin99
stomach188
testis32
umbilical cord363
uterus129
vascular251
Health State
TissuesTPM*
normal156
adrenal tumor237
bladder carcinoma284
breast (mammary gland) tumor42
cervical tumor144
chondrosarcoma169
colorectal tumor151
gastrointestinal tumor202
germ cell tumor26
glioma167
head and neck tumor29
kidney tumor116
leukemia158
liver tumor447
lung tumor136
lymphoma83
non-neoplasia93
ovarian tumor13
pancreatic tumor38
primitive neuroectodermal tumor of the CNS47
prostate cancer202
skin tumor15
soft tissue/muscle tissue tumor447
uterine tumor77
Developmental Stage
TissuesTPM*
adult136
embryoid body157
blastocyst65
neonate160
fetus145
infant42
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue59.8
adrenal gland61.4
appendix90.8
bone marrow124.4
cerebral cortex52.8
colon218.5
duodenum171.3
esophagus359.1
gallbladder84.9
heart muscle41.7
kidney167.5
liver117
lung74
lymph node71.2
ovary45.1
pancreas28.2
placenta66.3
prostate72.5
salivary gland64.6
skin107.9
small intestine172.3
spleen52.9
stomach111
testis23.4
thyroid gland49.4
urinary bladder83.4
Tissues
TissuesExpression level
adrenal glandLow
appendixHigh
breastHigh
bronchusHigh
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisLow
esophagusHigh
fallopian tubeHigh
heart muscleLow
hippocampusLow
kidneyMedium
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaHigh
pancreasLow
placentaHigh
rectumHigh
salivary glandMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleLow
spleenMedium
stomach 1High
stomach 2Medium
testisMedium
tonsilLow
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*187700, gene) Thioredoxin; TXNOMIM


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