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> Protein (NX_P10606)
Protein (NX_P10606)
Protein
Gene SymbolCOX5B to neXtProt (NX_P10606)
DescriptionCytochrome c oxidase subunit 5B, mitochondrial
Chromosome2
Location2q11.2 (98262503 ~ 98264846) to Ensembl
Sequene Features : Isoforms 1, Variants 10, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.hydrogen ion transmembrane transport
.small molecule metabolic process
.cellular metabolic process
  + 4 more...
.metal ion binding
.cytochrome-c oxidase activity
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 10 6
2014-09-19protein level
1 9 6
2014-05-27protein level
1 9 6
2014-02-25protein level
1 9 6
2013-12-09protein level
1 8 6
2013-11-01protein level
1 8 3
2013-09-12protein level
1 8 0
2013-08-17protein level
1 8 0
2013-07-15protein level
1 6 0
2013-06-11protein level
1 6 0
2013-02-12protein level
1 4 1
2012-12-20protein level
1 4 1
2012-10-30protein level
1 3 1
2012-10-07protein level
1 3 1
2012-08-24protein level
1 3 1
2012-07-28protein level
1 3 1
2012-06-08protein level
1 5 1
2012-05-07protein level
1 5 1
2012-04-10protein level
1 5 1
2012-01-13protein level
1 4 1
2011-12-20protein level
1 4 1
2011-11-11protein level
1 4 1
2011-08-23protein level
1 4 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P10606-1
7 0 0 13686.903
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1053725,EBI-711810 BHLHE40  
  .negative regulation of transcription, DNA-templated
.negative regulation of sequence-specific DNA binding transcription factor activity
.entrainment of circadian clock by photoperiod
  + 4 more...
.E-box binding
.protein heterodimerization activity
.MRF binding
  + 10 more...
.Golgi apparatus
.nucleolus
.nucleoplasm
.nucleus
2 EBI-1053725,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
3 EBI-1053725,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
4 EBI-1053725,EBI-1181367 CDR2  
  .N/A .N/A .cytoplasm
5 EBI-1053725,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
6 EBI-1053725,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
7 EBI-1053725,EBI-8638439 CCDC36  
  .positive regulation of defense response to virus by host .N/A .N/A
8 EBI-1053725,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
9 EBI-1053725,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland60
ascites50
blood40
bone69
bone marrow41
brain42
cervix20
connective tissue26
ear124
embryonic tissue37
eye71
heart156
intestine206
kidney66
liver336
lung26
lymph node22
mammary gland39
muscle300
ovary108
pancreas112
pituitary gland181
placenta31
prostate73
salivary gland49
skin61
spleen18
stomach41
testis16
thyroid85
tonsil58
umbilical cord217
uterus17
vascular38
Health State
TissuesTPM*
normal58
breast (mammary gland) tumor53
cervical tumor28
chondrosarcoma60
colorectal tumor151
gastrointestinal tumor25
germ cell tumor34
glioma65
head and neck tumor29
kidney tumor58
leukemia52
liver tumor93
lung tumor38
ovarian tumor91
pancreatic tumor114
primitive neuroectodermal tumor of the CNS23
prostate cancer77
skin tumor103
soft tissue/muscle tissue tumor23
uterine tumor11
Developmental Stage
TissuesTPM*
adult86
embryoid body14
blastocyst48
neonate96
fetus71
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue109
adrenal gland93.9
appendix57.2
bone marrow63.7
cerebral cortex80.9
colon171.8
duodenum142.8
esophagus53.4
gallbladder34.7
heart muscle224.7
kidney159.8
liver111.7
lung47.7
lymph node43.8
ovary45.7
pancreas33.9
placenta42.7
prostate80
salivary gland80.5
skin51.2
small intestine116.3
spleen65.5
stomach123
testis41.5
thyroid gland43.3
urinary bladder43
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowHigh
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleHigh
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2High
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*123866, gene) Cytochrome c oxidase, subunit vb; COX5BOMIM


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