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> Protein (NX_P10644)
Protein (NX_P10644)
Protein
Gene SymbolPRKAR1A to neXtProt (NX_P10644)
DescriptioncAMP-dependent protein kinase type I-alpha regulatory subunit
Chromosome17
Location17q24.2 (66507921 ~ 66547460) to Ensembl
Sequene Features : Isoforms 2, Variants 59, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cAMP-dependent protein kinase activity
.cellular response to glucagon stimulus
.cardiac muscle cell proliferation
  + 20 more...
.protein kinase A catalytic subunit binding
.ubiquitin protein ligase binding
.cAMP binding
  + 2 more...
.ciliary base
.protein complex
.neuromuscular junction
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 59 12
2014-09-19protein level
2 42 12
2014-05-27protein level
2 42 14
2014-02-25protein level
1 40 14
2013-12-09protein level
1 37 14
2013-11-01protein level
1 36 10
2013-09-12protein level
1 36 11
2013-08-17protein level
1 36 12
2013-07-15protein level
1 21 7
2013-06-11protein level
1 21 7
2013-02-12protein level
1 14 7
2012-12-20protein level
1 14 7
2012-10-30protein level
1 14 7
2012-10-07protein level
1 14 7
2012-08-24protein level
1 14 7
2012-07-28protein level
1 13 7
2012-06-08protein level
1 17 7
2012-05-07protein level
1 6 7
2012-04-10protein level
1 6 7
2012-01-13protein level
1 6 7
2011-12-20protein level
1 6 7
2011-11-11protein level
1 6 7
2011-08-23protein level
1 6 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P10644-1
3 12 2 42954.8457
NX_P10644-2
1 12 2 37979.2141
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-476431,EBI-476586 PRKACA  
  .regulation of tight junction assembly
.negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
.cell communication by electrical coupling involved in cardiac conduction
  + 47 more...
.protein kinase A regulatory subunit binding
.ubiquitin protein ligase binding
.protein kinase binding
  + 3 more...
.ciliary base
.sperm midpiece
.extracellular exosome
  + 11 more...
2 EBI-476431,EBI-476409 RFC2  
  .error-free translesion synthesis
.DNA damage response, detection of DNA damage
.error-prone translesion synthesis
  + 13 more...
.ATP binding
.DNA binding
.Golgi apparatus
.DNA replication factor C complex
.nucleoplasm
3 EBI-476431,EBI-4302903 PRKX  
  .regulation of epithelial cell differentiation involved in kidney development
.kidney morphogenesis
.epithelial tube morphogenesis
  + 10 more...
.ATP binding
.cAMP-dependent protein kinase activity
.cytoplasm
.nucleus
4 EBI-476431,EBI-1053182 SET  
  .negative regulation of transcription, DNA-templated
.negative regulation of neuron apoptotic process
.negative regulation of catalytic activity
  + 9 more...
.histone binding
.protein phosphatase type 2A regulator activity
.protein phosphatase inhibitor activity
.DNA binding
.perinuclear region of cytoplasm
.protein complex
.cytosol
  + 4 more...
5 EBI-476431,EBI-746969 GABARAPL1  
  .membrane fusion
.nucleophagy
.mitochondrion degradation
.autophagic vacuole assembly
.GABA receptor binding
.beta-tubulin binding
.Tat protein binding
.microtubule binding
.cell body
.dendrite cytoplasm
.dendrite membrane
  + 10 more...
6 EBI-476431,EBI-742388 PLEKHF2  
  .protein transport .metal ion binding .early endosome membrane
.transport vesicle
.endoplasmic reticulum
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland91
ascites25
bladder267
blood229
bone97
bone marrow102
brain650
cervix41
connective tissue321
ear248
embryonic tissue272
esophagus347
eye172
heart245
intestine146
kidney232
larynx255
liver155
lung104
lymph158
lymph node378
mammary gland198
mouth634
muscle122
nerve193
ovary78
pancreas117
parathyroid339
pharynx24
pituitary gland181
placenta183
prostate110
salivary gland98
skin279
spleen112
stomach209
testis363
thymus652
thyroid236
trachea3939
umbilical cord72
uterus512
vascular271
Health State
TissuesTPM*
normal342
adrenal tumor158
bladder carcinoma170
breast (mammary gland) tumor193
cervical tumor57
chondrosarcoma144
colorectal tumor168
esophageal tumor405
gastrointestinal tumor185
germ cell tumor254
glioma121
head and neck tumor418
kidney tumor232
leukemia105
liver tumor177
lung tumor58
lymphoma138
non-neoplasia351
ovarian tumor105
pancreatic tumor76
primitive neuroectodermal tumor of the CNS94
prostate cancer96
retinoblastoma193
skin tumor311
soft tissue/muscle tissue tumor463
uterine tumor177
Developmental Stage
TissuesTPM*
adult186
embryoid body257
blastocyst227
neonate225
fetus244
infant42
juvenile125
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue129.4
adrenal gland168.3
appendix126.8
bone marrow35
cerebral cortex149.9
colon76.2
duodenum52
esophagus108.8
gallbladder134
heart muscle328.9
kidney141.7
liver82.3
lung149.3
lymph node114.9
ovary190.4
pancreas37.6
placenta127.8
prostate112.9
salivary gland134.1
skin60.2
small intestine60.3
spleen121.2
stomach88.7
testis131
thyroid gland172.3
urinary bladder139.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixLow
breastLow
cerebellumLow
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumLow
endometrium 1Medium
endometrium 2Low
fallopian tubeLow
heart muscleMedium
hippocampusMedium
kidneyLow
lateral ventricleLow
lymph nodeMedium
ovaryLow
parathyroid glandLow
rectumLow
salivary glandMedium
small intestineLow
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Low
stomach 2Low
testisHigh
thyroid glandLow
tonsilMedium
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#101800, phenotype) Acrodysostosis 1, with or without hormone resistance; ACRDYS1OMIM
2(#160980, phenotype) Carney complex, type 1; CNC1OMIM
3(*188830, gene) Protein kinase, camp-dependent, regulatory, type i, alpha; PRKAR1AOMIM
4(#255960, phenotype) Myxoma, intracardiacOMIM
5(#610489, phenotype) Pigmented nodular adrenocortical disease, primary, 1; PPNAD1OMIM
6papillary thyroid;myxoma;endocrine;Carney complexCGP


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