Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P10721)
Protein (NX_P10721)
Protein
Gene SymbolKIT to neXtProt (NX_P10721)
DescriptionMast/stem cell growth factor receptor Kit
Chromosome4
Location4q12 (55524085 ~ 55606881) to Ensembl
Sequene Features : Isoforms 3, Variants 586, PTMs 30 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 586 30
2014-09-19protein level
3 551 30
2014-05-27protein level
3 551 30
2014-02-25protein level
3 379 30
2013-12-09protein level
3 370 30
2013-11-01protein level
3 370 30
2013-09-12protein level
3 370 30
2013-08-17protein level
3 370 30
2013-07-15protein level
3 370 30
2013-06-11protein level
3 370 30
2013-02-12protein level
3 370 72
2012-12-20protein level
3 369 72
2012-10-30protein level
3 371 72
2012-10-07protein level
3 371 30
2012-08-24protein level
3 371 30
2012-07-28protein level
3 371 30
2012-06-08protein level
3 43 30
2012-05-07protein level
3 42 27
2012-04-10protein level
3 42 27
2012-01-13protein level
3 42 27
2011-12-20protein level
3 57 27
2011-11-11protein level
3 57 27
2011-08-23protein level
2 45 20
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P10721-1
0 46 3 109793.7842
NX_P10721-2
0 46 3 109380.5832
NX_P10721-3
1 20 0 46628.3214
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1379503,EBI-346930 PIK3R2  
  .regulation of small GTPase mediated signal transduction
.leukocyte migration
.T cell receptor signaling pathway
  + 25 more...
.protein heterodimerization activity
.1-phosphatidylinositol-3-kinase regulator activity
.receptor tyrosine kinase binding
.protein phosphatase binding
.phosphatidylinositol 3-kinase complex
.cytosol
.nucleus
2 EBI-1379503,EBI-617737 SOCS2  
  .JAK-STAT cascade involved in growth hormone signaling pathway
.growth hormone receptor signaling pathway
.negative regulation of insulin receptor signaling pathway
  + 12 more...
.JAK pathway signal transduction adaptor activity
.insulin-like growth factor receptor binding
.growth hormone receptor binding
  + 2 more...
.cytosol
.cytoplasm
3 EBI-1379503,EBI-714146 SOCS3  
  .spongiotrophoblast differentiation
.trophoblast giant cell differentiation
.placenta blood vessel development
  + 16 more...
.protein kinase inhibitor activity .cytosol
.cytoplasm
4 EBI-1379503,EBI-3929549 SOCS6  
  .negative regulation of T cell activation
.negative regulation of JAK-STAT cascade
.regulation of growth
  + 6 more...
.protein kinase inhibitor activity .cytoplasm
.immunological synapse
5 EBI-1379503,EBI-3923013 SH2D1B  
  .positive regulation of innate immune response
.positive regulation of natural killer cell mediated immunity
.leukocyte activation involved in immune response
.protein binding, bridging .intracellular
6 EBI-1379503,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
7 EBI-1379503,EBI-740418 GRAP2  
  .T cell receptor signaling pathway
.innate immune response
.Fc-epsilon receptor signaling pathway
  + 4 more...
.SH3/SH2 adaptor activity .cytosol
.endosome
.cytoplasm
  + 2 more...
8 EBI-1379503,EBI-702336 BCAR3  
  .response to drug
.positive regulation of peptidyl-serine phosphorylation
.small GTPase mediated signal transduction
  + 2 more...
.guanyl-nucleotide exchange factor activity .N/A
9 EBI-1379503,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
10 EBI-1379503,EBI-1348 LCK  
  .positive regulation of intrinsic apoptotic signaling pathway
.cellular response to peptide hormone stimulus
.positive regulation of uterine smooth muscle contraction
  + 35 more...
.ATPase binding
.phosphatidylinositol 3-kinase binding
.identical protein binding
  + 12 more...
.extracellular exosome
.membrane raft
.extrinsic component of cytoplasmic side of plasma membrane
  + 6 more...
11 EBI-1379503,EBI-1055635 FES  
  .positive regulation of actin cytoskeleton reorganization
.regulation of cell motility
.regulation of vesicle-mediated transport
  + 19 more...
.phosphatidylinositol binding
.immunoglobulin receptor binding
.ATP binding
  + 2 more...
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasmic membrane-bounded vesicle
.microtubule cytoskeleton
  + 4 more...
12 EBI-1379503,EBI-515331 YES1  
  .cellular response to peptide hormone stimulus
.leukocyte migration
.ephrin receptor signaling pathway
  + 13 more...
.ion channel binding
.enzyme binding
.ATP binding
  + 3 more...
.extracellular exosome
.extrinsic component of cytoplasmic side of plasma membrane
.focal adhesion
  + 6 more...
13 EBI-1379503,EBI-79452 LYN  
  .positive regulation of dendritic cell apoptotic process
.negative regulation of intracellular signal transduction
.dendritic cell differentiation
  + 83 more...
.ion channel binding
.glycosphingolipid binding
.enzyme binding
  + 5 more...
.extracellular exosome
.perinuclear region of cytoplasm
.membrane raft
  + 11 more...
14 EBI-1379503,EBI-346340 HCK  
  .positive regulation of actin cytoskeleton reorganization
.regulation of podosome assembly
.cellular response to peptide hormone stimulus
  + 28 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.cell projection
.extrinsic component of cytoplasmic side of plasma membrane
.transport vesicle
  + 7 more...
15 EBI-1379503,EBI-1383732 FGR  
  .cellular response to peptide hormone stimulus
.defense response to Gram-positive bacterium
.regulation of phagocytosis
  + 22 more...
.Fc-gamma receptor I complex binding
.immunoglobulin receptor binding
.protein kinase binding
  + 4 more...
.extracellular exosome
.ruffle membrane
.extrinsic component of cytoplasmic side of plasma membrane
  + 5 more...
16 EBI-1379503,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
17 EBI-1379503,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
18 EBI-1379503,EBI-617403 PLCG2  
  .release of sequestered calcium ion into cytosol
.B cell receptor signaling pathway
.T cell receptor signaling pathway
  + 19 more...
.signal transducer activity
.phospholipase C activity
.phosphatidylinositol phospholipase C activity
.extracellular exosome
.plasma membrane
.cytosol
19 EBI-1379503,EBI-79387 PLCG1  
  .cellular response to epidermal growth factor stimulus
.positive regulation of release of sequestered calcium ion into cytosol
.leukocyte migration
  + 24 more...
.protein kinase binding
.calcium ion binding
.neurotrophin TRKA receptor binding
  + 3 more...
.cell projection
.lamellipodium
.COP9 signalosome
  + 5 more...
20 EBI-1379503,EBI-1026476 RASA1  
  .regulation of RNA metabolic process
.blood vessel morphogenesis
.ephrin receptor signaling pathway
  + 14 more...
.GTPase binding
.potassium channel inhibitor activity
.receptor binding
  + 2 more...
.intrinsic component of the cytoplasmic side of the plasma membrane
.cytosol
.cytoplasm
.ruffle
21 EBI-1379503,EBI-1379527 KITLG  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of mast cell proliferation
.positive regulation of peptidyl-tyrosine phosphorylation
  + 19 more...
.stem cell factor receptor binding .integral component of membrane
.plasma membrane
.cytoskeleton
  + 3 more...
22 EBI-1379503,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
23 EBI-1379503,EBI-78835 SHC1  
  .leukocyte migration
.neurotrophin TRK receptor signaling pathway
.positive regulation of DNA replication
  + 22 more...
.ephrin receptor binding
.protein kinase binding
.phospholipid binding
  + 6 more...
.Shc-EGFR complex
.plasma membrane
.cytosol
.mitochondrial matrix
24 EBI-1379503,EBI-7877438 TXK  
  .positive regulation of interferon-gamma-mediated signaling pathway
.T cell receptor signaling pathway
.protein autophosphorylation
  + 14 more...
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  + 2 more...
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
.nucleus
25 EBI-1379503,EBI-1102694 ABL2  
  .negative regulation of endothelial cell apoptotic process
.regulation of actin cytoskeleton reorganization
.regulation of cell motility
  + 41 more...
.actin filament binding
.manganese ion binding
.ATP binding
  + 6 more...
.dendritic spine
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
  + 3 more...
26 EBI-1379503,EBI-1211276 ZAP70  
  .T cell migration
.T cell aggregation
.T cell receptor signaling pathway
  + 19 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.T cell receptor complex
.extrinsic component of cytoplasmic side of plasma membrane
.cell-cell junction
  + 4 more...
27 EBI-1379503,EBI-886 CRK  
  .ephrin receptor signaling pathway
.neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 9 more...
.ephrin receptor binding
.SH2 domain binding
.extracellular exosome
.actin cytoskeleton
.plasma membrane
  + 3 more...
28 EBI-1379503,EBI-2105445 BLK  
  .cellular response to peptide hormone stimulus
.B cell receptor signaling pathway
.innate immune response
  + 6 more...
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
29 EBI-1379503,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
30 EBI-1379503,EBI-727062 SH3BP2  
  .positive regulation of signal transduction
.signal transduction
.SH3/SH2 adaptor activity .N/A
31 EBI-1379503,EBI-7256023 SHC2  
  .neurotrophin TRK receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
.insulin receptor signaling pathway
  + 3 more...
.receptor tyrosine kinase binding
.protein kinase binding
.plasma membrane
.cytosol
32 EBI-1379503,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
33 EBI-1379503,EBI-1383632 PTK6  
  .cellular response to retinoic acid
.negative regulation of protein tyrosine kinase activity
.intestinal epithelial cell differentiation
  + 12 more...
.identical protein binding
.ATP binding
.receptor binding
.non-membrane spanning protein tyrosine kinase activity
.extrinsic component of cytoplasmic side of plasma membrane
.cytoplasm
.nucleoplasm
  + 2 more...
34 EBI-1379503,EBI-970191 GRB7  
  .leukocyte migration
.stress granule assembly
.positive regulation of cell migration
  + 4 more...
.identical protein binding
.phosphatidylinositol binding
.protein kinase binding
  + 2 more...
.cell projection
.cytoplasmic stress granule
.focal adhesion
  + 2 more...
35 EBI-1379503,EBI-4402156 SHB  
  .vascular endothelial growth factor receptor signaling pathway
.cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity .plasma membrane
.cytosol
36 EBI-1379503,EBI-949753 TENC1  
  .multicellular organismal homeostasis
.intracellular signal transduction
.multicellular organism growth
  + 5 more...
.metal ion binding
.kinase binding
.phosphoprotein phosphatase activity
.focal adhesion
.plasma membrane
37 EBI-1379503,EBI-1220488 TNS3  
  .lung alveolus development
.cell migration
.positive regulation of cell proliferation
.N/A .focal adhesion
.cytoplasm
38 EBI-1379503,EBI-745980 SH2D3C  
  .positive regulation of signal transduction
.small GTPase mediated signal transduction
.JNK cascade
.guanyl-nucleotide exchange factor activity
.SH3/SH2 adaptor activity
.membrane
.cytoplasm
39 EBI-1379503,EBI-2623522 BLNK  
  .intracellular signal transduction
.B cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity
.transmembrane receptor protein tyrosine kinase adaptor activity
.plasma membrane
.cytosol
.cytoplasm
.intracellular
40 EBI-1379503,EBI-79084 SHC3  
  .neurotrophin TRK receptor signaling pathway
.synaptic transmission, glutamatergic
.insulin receptor signaling pathway
  + 5 more...
.receptor tyrosine kinase binding
.protein kinase binding
.signal transducer activity
.plasma membrane
.cytosol
41 EBI-1379503,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
42 EBI-1379503,EBI-7052301 PTPRU  
  .canonical Wnt signaling pathway
.response to glucocorticoid
.peptidyl-tyrosine dephosphorylation
  + 10 more...
.beta-catenin binding
.transmembrane receptor protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.cell-cell junction
.integral component of plasma membrane
.plasma membrane
43 EBI-1379503,EBI-3919324 HSH2D  
  .negative regulation of mitochondrial depolarization
.T cell activation
.positive regulation of signal transduction
.negative regulation of B cell apoptotic process
.N/A .cytosol
.mitochondrion
.nucleus
44 EBI-1379503,EBI-1222854 SLA2  
  .negative regulation of B cell activation
.antigen receptor-mediated signaling pathway
.negative regulation of calcium-mediated signaling
  + 6 more...
.protein N-terminus binding
.SH3/SH2 adaptor activity
.cytoplasmic membrane-bounded vesicle
.endosome membrane
.plasma membrane
  + 2 more...
45 EBI-1379503,EBI-3389814 TNS1  
  .fibroblast migration
.cell-substrate junction assembly
.poly(A) RNA binding .cell surface
.focal adhesion
.cytoskeleton
.cytoplasm
46 EBI-1379503,EBI-490630 SH2D2A  
  .vascular endothelial growth factor receptor signaling pathway
.cell differentiation
.positive regulation of signal transduction
  + 3 more...
.SH3/SH2 adaptor activity .cytosol
.cytoplasm
47 EBI-1379503,EBI-6083058 STAP1  
  .positive regulation of actin cytoskeleton reorganization
.positive regulation of non-membrane spanning protein tyrosine kinase activity
.positive regulation of microglial cell activation
  + 10 more...
.protein kinase binding
.phospholipid binding
.SH3/SH2 adaptor activity
  + 2 more...
.protein complex
.mitochondrion
.cytoplasm
.nucleus
48 EBI-1379503,EBI-7879749 SH2B3  
  .intracellular signal transduction
.embryonic hemopoiesis
.cell differentiation
.blood coagulation
.phosphate ion binding
.signaling adaptor activity
.signal transducer activity
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
bladder33
brain33
connective tissue46
ear62
embryonic tissue32
eye23
heart44
intestine12
kidney23
liver4
lung17
mammary gland39
muscle37
nerve64
ovary177
pancreas14
placenta3
skin52
spleen18
testis2
thymus12
trachea96
umbilical cord72
uterus21
Health State
TissuesTPM*
normal29
bladder carcinoma56
breast (mammary gland) tumor21
chondrosarcoma12
colorectal tumor26
germ cell tumor3
glioma9
kidney tumor14
non-neoplasia20
ovarian tumor236
pancreatic tumor19
primitive neuroectodermal tumor of the CNS7
soft tissue/muscle tissue tumor15
uterine tumor22
Developmental Stage
TissuesTPM*
adult24
embryoid body14
blastocyst32
neonate32
fetus39
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.9
adrenal gland2
appendix5.4
bone marrow4.1
cerebral cortex5.8
colon15
duodenum9.1
esophagus13.3
gallbladder22.6
heart muscle2.7
kidney11.5
lung20.2
lymph node3.5
ovary42.6
pancreas1.3
placenta8.8
prostate5.6
salivary gland15.4
skin21.3
small intestine12.8
spleen5
stomach15.9
testis6.7
thyroid gland46.5
urinary bladder14.3
Tissues
TissuesExpression level
bone marrowLow
breastMedium
cerebellumMedium
lungMedium
ovaryMedium
skin 1Medium
skin 2Low
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*164920, gene) V-kit hardy-zuckerman 4 feline sarcoma viral oncogene homolog; KITOMIM
2(#172800, phenotype) Piebald trait; PBTOMIM
3(#273300, phenotype) Testicular germ cell tumor; TGCTOMIM
4(#601626, phenotype) Leukemia, acute myeloid; AMLOMIM
5(#606764, phenotype) Gastrointestinal stromal tumor; GISTOMIM
6gastrointestinal stromal tumour;acute myelogenous leukemia;testicular germ cell tumour;mastocytosis;mucosal melanoma;epithelioma;Familial gastrointestinal stromal tumour;Piebald traitCGP


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center