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> Protein (NX_P10809)
Protein (NX_P10809)
Protein
Gene SymbolHSPD1 to neXtProt (NX_P10809)
Description60 kDa heat shock protein, mitochondrial
Chromosome2
Location2q33.1 (198351305 ~ 198381461) to Ensembl
Sequene Features : Isoforms 2, Variants 60, PTMs 66 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein maturation
.chaperone-mediated protein complex assembly
.positive regulation of T cell activation
  + 21 more...
.chaperone binding
.unfolded protein binding
.poly(A) RNA binding
  + 8 more...
.extracellular exosome
.lipopolysaccharide receptor complex
.protein complex
  + 13 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 60 66
2014-09-19protein level
1 39 66
2014-05-27protein level
1 39 66
2014-02-25protein level
1 39 52
2013-12-09protein level
1 33 52
2013-11-01protein level
1 32 40
2013-09-12protein level
1 32 27
2013-08-17protein level
1 32 27
2013-07-15protein level
1 22 21
2013-06-11protein level
1 22 21
2013-02-12protein level
1 12 22
2012-12-20protein level
1 12 22
2012-10-30protein level
1 10 22
2012-10-07protein level
1 10 22
2012-08-24protein level
1 8 22
2012-07-28protein level
1 8 22
2012-06-08protein level
1 13 22
2012-05-07protein level
1 13 22
2012-04-10protein level
1 13 22
2012-01-13protein level
1 17 21
2011-12-20protein level
1 17 21
2011-11-11protein level
1 17 19
2011-08-23protein level
1 17 16
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P10809-1
23 5 0 61016.2038
NX_P10809-2
1 5 0 17089.0747
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-352528,EBI-1052678 RGS20  
  .positive regulation of GTPase activity
.termination of G-protein coupled receptor signaling pathway
.regulation of G-protein coupled receptor protein signaling pathway
.GTPase activator activity .plasma membrane
.trans-Golgi network
.cytoplasm
.nucleus
2 EBI-352528,EBI-3958099 KRTAP5-9  
  .epidermis development .N/A .keratin filament
3 EBI-352528,EBI-349905 BRCA1  
  .positive regulation of histone H4-K16 acetylation
.positive regulation of histone H3-K9 acetylation
.negative regulation of reactive oxygen species metabolic process
  + 51 more...
.androgen receptor binding
.transcription regulatory region DNA binding
.ubiquitin protein ligase binding
  + 9 more...
.BRCA1-A complex
.protein complex
.BRCA1-BARD1 complex
  + 9 more...
4 EBI-352528,EBI-741760 FHIT  
  .intrinsic apoptotic signaling pathway by p53 class mediator
.negative regulation of proteasomal ubiquitin-dependent protein catabolic process
.nucleotide metabolic process
  + 4 more...
.bis(5'-adenosyl)-triphosphatase activity
.identical protein binding
.ubiquitin protein ligase binding
  + 3 more...
.extracellular exosome
.cytosol
.mitochondrion
  + 2 more...
5 EBI-352528,EBI-10171774 KRTAP10-8  
  .N/A .N/A .keratin filament
6 EBI-352528,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
7 EBI-352528,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
8 EBI-352528,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
9 EBI-352528,EBI-748741 SAMD3  
  .N/A .N/A .N/A
10 EBI-352528,EBI-739624 CEP70  
  .organelle organization
.mitotic cell cycle
.G2/M transition of mitotic cell cycle
.N/A .nuclear membrane
.cytosol
.centrosome
  + 2 more...
11 EBI-352528,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
12 EBI-352528,EBI-2864441 MFHAS1  
  .N/A .N/A .N/A
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue466
adrenal gland2914
ascites778
bladder703
blood736
bone195
bone marrow759
brain486
cervix494
connective tissue214
ear248
embryonic tissue469
esophagus1091
eye215
heart368
intestine456
kidney687
larynx85
liver681
lung289
lymph699
lymph node44
mammary gland224
mouth272
muscle404
nerve193
ovary266
pancreas107
parathyroid48
pharynx294
pituitary gland181
placenta109
prostate142
skin123
stomach324
testis34
thymus37
thyroid150
tonsil117
umbilical cord217
uterus150
vascular58
Health State
TissuesTPM*
normal346
adrenal tumor1106
bladder carcinoma454
breast (mammary gland) tumor279
cervical tumor637
chondrosarcoma205
colorectal tumor622
esophageal tumor1159
gastrointestinal tumor497
germ cell tumor949
glioma289
head and neck tumor239
kidney tumor566
leukemia698
liver tumor1218
lung tumor535
lymphoma609
non-neoplasia217
ovarian tumor315
pancreatic tumor57
primitive neuroectodermal tumor of the CNS1228
prostate cancer317
retinoblastoma689
skin tumor358
soft tissue/muscle tissue tumor678
uterine tumor88
Developmental Stage
TissuesTPM*
adult327
embryoid body285
blastocyst667
neonate772
fetus307
infant1233
juvenile2483
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue83.2
adrenal gland427.8
appendix95.5
bone marrow69.5
cerebral cortex56.9
colon104.2
duodenum96.5
esophagus55.9
gallbladder65.5
heart muscle58.7
kidney151
liver145.7
lung46.2
lymph node91.5
ovary94.6
pancreas47.4
placenta94
prostate66.1
salivary gland39.9
skin44
small intestine88.7
spleen51.2
stomach61.4
testis44
thyroid gland85.2
urinary bladder65.4
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowMedium
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonHigh
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverHigh
lungMedium
lymph nodeMedium
oral mucosaMedium
ovaryHigh
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateHigh
rectumHigh
salivary glandMedium
seminal vesicleLow
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1High
stomach 2Medium
testisHigh
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*118190, gene) Heat-shock 60-kd protein 1; HSPD1OMIM
2(#605280, phenotype) Spastic paraplegia 13, autosomal dominant; SPG13OMIM
3(#612233, phenotype) Leukodystrophy, hypomyelinating, 4; HLD4OMIM


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