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> Protein (NX_P10909)
Protein (NX_P10909)
Protein
Gene SymbolCLU to neXtProt (NX_P10909)
DescriptionClusterin
Chromosome8
Location8p21.1 (27454434 ~ 27472548) to Ensembl
Sequene Features : Isoforms 5, Variants 77, PTMs 14 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.positive regulation of neurofibrillary tangle assembly
  + 34 more...
.misfolded protein binding
.chaperone binding
.ubiquitin protein ligase binding
.apical dendrite
.neurofibrillary tangle
.blood microparticle
  + 15 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 77 14
2014-09-19protein level
5 55 14
2014-05-27protein level
5 55 14
2014-02-25protein level
5 55 14
2013-12-09protein level
5 43 13
2013-11-01protein level
5 40 13
2013-09-12protein level
5 40 13
2013-08-17protein level
5 40 13
2013-07-15protein level
5 31 12
2013-06-11protein level
5 31 12
2013-02-12protein level
5 17 62
2012-12-20protein level
5 18 62
2012-10-30protein level
5 20 62
2012-10-07protein level
5 20 15
2012-08-24protein level
5 16 15
2012-07-28protein level
5 16 15
2012-06-08protein level
5 24 15
2012-05-07protein level
5 24 15
2012-04-10protein level
5 24 15
2012-01-13protein level
5 21 15
2011-12-20protein level
5 21 15
2011-11-11protein level
5 21 15
2011-08-23protein level
5 21 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P10909-1
0 21 0 52460.8579
NX_P10909-2
3 21 0 57795.4262
NX_P10909-3
0 12 0 32342.8997
NX_P10909-4
0 20 0 48771.9949
NX_P10909-5
0 21 0 53608.3661
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1104674,EBI-852851 FOS  
  .cellular response to calcium ion
.SMAD protein signal transduction
.response to cAMP
  + 44 more...
.R-SMAD binding
.transcription regulatory region DNA binding
.transcription factor binding
  + 3 more...
.neuron projection
.membrane
.cytosol
  + 4 more...
2 EBI-1104674,EBI-8588930 ADCYAP1  
  .positive regulation of somatostatin secretion
.positive regulation of chemokine (C-C motif) ligand 5 production
.cellular response to glucocorticoid stimulus
  + 38 more...
.peptide hormone receptor binding
.pituitary adenylate cyclase activating polypeptide activity
.neuropeptide hormone activity
  + 2 more...
.terminal bouton
.extracellular space
.extracellular region
3 EBI-1104674,EBI-781384 PPARG  
  .negative regulation of pancreatic stellate cell proliferation
.response to metformin
.cellular response to hyperoxia
  + 64 more...
.alpha-actinin binding
.arachidonic acid binding
.retinoid X receptor binding
  + 15 more...
.RNA polymerase II transcription factor complex
.perinuclear region of cytoplasm
.cytosol
  + 2 more...
4 EBI-4322678,EBI-287195 BCL2L1  
  .positive regulation of intrinsic apoptotic signaling pathway
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
  + 42 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 2 more...
.Bcl-2 family protein complex
.nuclear membrane
.synaptic vesicle membrane
  + 11 more...
5 EBI-1104674,EBI-529989 DISC1  
  .positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of synapse maturation
.canonical Wnt signaling pathway
  + 10 more...
.N/A .postsynaptic membrane
.ciliary basal body
.cell junction
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland455
ascites75
bladder100
blood229
bone977
brain1790
cervix453
connective tissue3266
ear372
embryonic tissue145
esophagus248
eye1632
heart100
intestine116
kidney379
larynx1448
liver930
lung262
lymph node289
mammary gland700
mouth151
muscle235
nerve3411
ovary945
pancreas557
parathyroid874
pharynx122
pituitary gland605
placenta279
prostate258
salivary gland345
skin23
spleen37
stomach459
testis675
thyroid3542
tonsil293
umbilical cord290
uterus482
vascular116
Health State
TissuesTPM*
normal619
adrenal tumor553
bladder carcinoma56
breast (mammary gland) tumor633
cervical tumor405
chondrosarcoma1122
colorectal tumor88
esophageal tumor289
gastrointestinal tumor177
germ cell tumor79
glioma4104
head and neck tumor1173
kidney tumor784
leukemia201
liver tumor197
lung tumor233
lymphoma373
non-neoplasia4533
ovarian tumor1089
pancreatic tumor409
primitive neuroectodermal tumor of the CNS133
prostate cancer105
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor39
uterine tumor1098
Developmental Stage
TissuesTPM*
embryoid body142
blastocyst130
neonate128
fetus448
infant425
juvenile755
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue996.5
adrenal gland2554.1
appendix773.6
bone marrow32.3
cerebral cortex3549.3
colon319.4
duodenum269.4
esophagus601
gallbladder2189.5
heart muscle337
kidney631.8
liver3915.2
lung482.9
lymph node1617.3
ovary673.3
pancreas1022.6
placenta169.9
prostate948
salivary gland484.5
skin175.1
small intestine248.1
spleen287.5
stomach868.8
testis2393.4
thyroid gland1218.1
urinary bladder1136.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*185430, gene) Clusterin; CLUOMIM


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