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> Protein (NX_P10912)
Protein (NX_P10912)
Protein
Gene SymbolGHR to neXtProt (NX_P10912)
DescriptionGrowth hormone receptor
Chromosome5
Location5p12 (42423879 ~ 42721979) to Ensembl
Sequene Features : Isoforms 4, Variants 161, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.JAK-STAT cascade involved in growth hormone signaling pathway
.growth hormone receptor signaling pathway
.positive regulation of peptidyl-tyrosine phosphorylation
  + 25 more...
.proline-rich region binding
.protein homodimerization activity
.protein kinase binding
  + 3 more...
.growth hormone receptor complex
.receptor complex
.integral component of membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 161 8
2014-09-19protein level
4 122 8
2014-05-27protein level
4 122 8
2014-02-25protein level
4 119 8
2013-12-09protein level
4 100 8
2013-11-01protein level
4 94 8
2013-09-12protein level
4 94 8
2013-08-17protein level
4 94 8
2013-07-15protein level
4 72 8
2013-06-11protein level
4 72 8
2013-02-12protein level
4 50 31
2012-12-20protein level
4 48 31
2012-10-30protein level
4 58 31
2012-10-07protein level
4 58 8
2012-08-24protein level
4 55 8
2012-07-28protein level
4 56 8
2012-06-08protein level
4 31 8
2012-05-07protein level
4 31 8
2012-04-10protein level
4 31 8
2012-01-13protein level
4 31 8
2011-12-20protein level
4 31 8
2011-11-11protein level
4 31 8
2011-08-23protein level
4 31 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P10912-1
0 25 0 71453.8201
NX_P10912-2
0 11 0 34086.7442
NX_P10912-3
0 11 0 33866.6752
NX_P10912-4
1 23 0 69192.5625
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-286316,EBI-1026046 GH1  
  .bone maturation
.JAK-STAT cascade involved in growth hormone signaling pathway
.growth hormone receptor signaling pathway
  + 12 more...
.metal ion binding
.growth factor activity
.prolactin receptor binding
.growth hormone receptor binding
.extracellular space
.extracellular region
2 EBI-286316,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
3 EBI-286316,EBI-984930 PTPN2  
  .negative regulation of platelet-derived growth factor receptor-beta signaling pathway
.negative regulation of positive thymic T cell selection
.negative regulation of macrophage colony-stimulating factor signaling pathway
  + 31 more...
.receptor tyrosine kinase binding
.syntaxin binding
.protein kinase binding
  + 2 more...
.plasma membrane
.endoplasmic reticulum-Golgi intermediate compartment
.endoplasmic reticulum
  + 2 more...
4 EBI-286316,EBI-968788 PTPN1  
  .positive regulation of receptor catabolic process
.peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
.negative regulation of PERK-mediated unfolded protein response
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.receptor tyrosine kinase binding
  + 4 more...
.cytoplasmic side of endoplasmic reticulum membrane
.sorting endosome
.cytoplasmic vesicle
  + 3 more...
5 EBI-286316,EBI-1265766 PTPRB  
  .peptidyl-tyrosine dephosphorylation
.dephosphorylation
.phosphate-containing compound metabolic process
  + 2 more...
.transmembrane receptor protein tyrosine phosphatase activity .receptor complex
.integral component of plasma membrane
6 EBI-286316,EBI-1047946 PTPN3  
  .regulation of sodium ion transmembrane transporter activity
.regulation of membrane depolarization during action potential
.liver regeneration
  + 4 more...
.ATPase binding
.sodium channel regulator activity
.protein tyrosine phosphatase activity
.phosphotyrosine binding
.cytoplasmic side of plasma membrane
.cytoskeleton
.cytoplasm
7 EBI-286316,EBI-742898 PTPN9  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.non-membrane spanning protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.cytoplasm
8 EBI-286316,EBI-2264500 PTPRJ  
  .negative regulation of receptor activity
.contact inhibition
.negative regulation of protein kinase B signaling
  + 21 more...
.delta-catenin binding
.mitogen-activated protein kinase binding
.gamma-catenin binding
  + 5 more...
.extracellular exosome
.ruffle membrane
.cell junction
  + 6 more...
9 EBI-286316,EBI-1265847 DUSP7  
  .stress-activated MAPK cascade
.neurotrophin TRK receptor signaling pathway
.innate immune response
  + 15 more...
.MAP kinase tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.cytosol
.nucleoplasm
10 EBI-286316,EBI-1267176 PTPRH  
  .peptidyl-tyrosine dephosphorylation
.apoptotic process
.protein dephosphorylation
.transmembrane receptor protein tyrosine phosphatase activity .integral component of plasma membrane
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland60
bladder33
bone55
connective tissue6
ear62
embryonic tissue9
eye4
heart11
kidney18
liver24
mammary gland6
muscle37
nerve193
ovary9
pancreas9
parathyroid97
prostate21
skin4
testis9
uterus8
Health State
TissuesTPM*
normal12
non-neoplasia10
ovarian tumor13
pancreatic tumor9
Developmental Stage
TissuesTPM*
adult9
fetus17
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue72.4
adrenal gland6.3
appendix2.1
cerebral cortex1.5
colon5.9
duodenum1.3
esophagus4.9
gallbladder6.4
heart muscle7.5
kidney10.9
liver92.2
lung4.2
lymph node1.6
ovary8.8
pancreas1.1
placenta4.8
prostate11.5
salivary gland2.5
skin4.4
small intestine2.4
spleen3.7
stomach2.9
testis2.5
thyroid gland4.1
urinary bladder4
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(#143890, phenotype) Hypercholesterolemia, familialOMIM
2(#262500, phenotype) Laron syndromeOMIM
3(*600946, gene) Growth hormone receptor; GHROMIM
4(#604271, phenotype) Short stature, idiopathic, autosomalOMIM


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