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> Protein (NX_P11274)
Protein (NX_P11274)
Protein
Gene SymbolBCR to neXtProt (NX_P11274)
DescriptionBreakpoint cluster region protein
Chromosome22
Location22q11.23 (23521891 ~ 23660224) to Ensembl
Sequene Features : Isoforms 2, Variants 127, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of cell cycle
.regulation of small GTPase mediated signal transduction
.neuromuscular process controlling balance
  + 15 more...
.kinase activity
.ATP binding
.GTPase activator activity
  + 3 more...
.extracellular exosome
.postsynaptic membrane
.protein complex
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 127 12
2014-09-19protein level
2 100 12
2014-05-27protein level
2 100 14
2014-02-25protein level
2 101 13
2013-12-09protein level
2 81 13
2013-11-01protein level
2 78 13
2013-09-12protein level
2 78 13
2013-08-17protein level
2 78 13
2013-07-15protein level
2 55 13
2013-06-11protein level
2 55 13
2013-02-12protein level
2 42 28
2012-12-20protein level
2 43 28
2012-10-30protein level
2 50 28
2012-10-07protein level
2 50 14
2012-08-24protein level
2 47 14
2012-07-28protein level
2 47 14
2012-06-08protein level
2 56 14
2012-05-07protein level
2 47 14
2012-04-10protein level
2 47 14
2012-01-13protein level
2 36 14
2011-12-20protein level
2 36 14
2011-11-11protein level
2 36 12
2011-08-23protein level
2 35 12
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P11274-1
3 54 2 142729.5704
NX_P11274-2
1 54 2 137642.0804
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-712838,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-8658094,EBI-968788 PTPN1  
  .positive regulation of receptor catabolic process
.peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
.negative regulation of PERK-mediated unfolded protein response
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.receptor tyrosine kinase binding
  + 4 more...
.cytoplasmic side of endoplasmic reticulum membrane
.sorting endosome
.cytoplasmic vesicle
  + 3 more...
3 EBI-712838,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
4 EBI-712838,EBI-4398527 TNKS2  
  .positive regulation of canonical Wnt signaling pathway
.protein auto-ADP-ribosylation
.protein localization to chromosome, telomeric region
  + 6 more...
.metal ion binding
.enzyme binding
.NAD+ ADP-ribosyltransferase activity
.perinuclear region of cytoplasm
.cytosol
.cytoplasm
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
ascites150
bladder33
blood40
bone27
bone marrow41
brain70
cervix103
connective tissue33
embryonic tissue61
esophagus49
eye86
heart11
intestine68
kidney61
larynx42
liver29
lung68
lymph180
lymph node66
mammary gland79
mouth30
muscle47
nerve128
ovary88
pancreas93
parathyroid48
pharynx24
pituitary gland60
placenta77
prostate36
skin128
spleen74
stomach20
testis41
thymus75
thyroid42
trachea57
umbilical cord290
uterus60
vascular96
Health State
TissuesTPM*
normal61
breast (mammary gland) tumor21
cervical tumor28
chondrosarcoma48
colorectal tumor97
esophageal tumor57
gastrointestinal tumor67
germ cell tumor64
glioma195
head and neck tumor44
kidney tumor87
leukemia95
liver tumor41
lung tumor116
lymphoma221
non-neoplasia72
ovarian tumor105
pancreatic tumor180
primitive neuroectodermal tumor of the CNS39
prostate cancer38
retinoblastoma107
skin tumor159
soft tissue/muscle tissue tumor47
uterine tumor88
Developmental Stage
TissuesTPM*
adult67
embryoid body57
blastocyst81
fetus41
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue18
adrenal gland10.9
appendix16
bone marrow24
cerebral cortex26.3
colon13
duodenum9.8
esophagus22.6
gallbladder12
heart muscle7.2
kidney29.6
liver5.8
lung16.6
lymph node14.7
ovary10
pancreas7.6
placenta13.2
prostate12
salivary gland14.4
skin14.4
small intestine10.3
spleen14.5
stomach18.8
testis27.2
thyroid gland23.2
urinary bladder13.7
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowLow
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderMedium
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeLow
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
soft tissue 1Medium
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*151410, gene) Breakpoint cluster region; BCROMIM
2(#608232, phenotype) Leukemia, chronic myeloid; CMLOMIM


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