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> Protein (NX_P11473)
Protein (NX_P11473)
Protein
Gene SymbolVDR to neXtProt (NX_P11473)
DescriptionVitamin D3 receptor
Chromosome12
Location12q13.11 (48235320 ~ 48336831) to Ensembl
Sequene Features : Isoforms 2, Variants 76, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.vitamin D receptor signaling pathway
.mammary gland branching involved in pregnancy
.regulation of calcidiol 1-monooxygenase activity
  + 20 more...
.lithocholic acid binding
.calcitriol binding
.retinoid X receptor binding
  + 6 more...
.RNA polymerase II transcription factor complex
.receptor complex
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 76 0
2014-09-19protein level
2 66 0
2014-05-27protein level
2 66 0
2014-02-25protein level
2 66 0
2013-12-09protein level
2 51 0
2013-11-01protein level
2 51 0
2013-09-12protein level
2 51 0
2013-08-17protein level
2 51 0
2013-07-15protein level
1 43 0
2013-06-11protein level
1 43 0
2013-02-12protein level
1 31 0
2012-12-20protein level
1 27 0
2012-10-30protein level
1 31 0
2012-10-07protein level
1 31 0
2012-08-24protein level
1 24 0
2012-07-28protein level
1 24 0
2012-06-08protein level
1 26 0
2012-05-07protein level
1 26 0
2012-04-10protein level
1 26 0
2012-01-13protein level
1 24 0
2011-12-20protein level
1 24 0
2011-11-11protein level
1 24 0
2011-08-23protein level
1 24 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P11473-1
1 19 0 48257.6022
NX_P11473-2
3 19 0 53847.4486
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-286357,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-286357,EBI-1047946 PTPN3  
  .regulation of sodium ion transmembrane transporter activity
.regulation of membrane depolarization during action potential
.liver regeneration
  + 4 more...
.ATPase binding
.sodium channel regulator activity
.protein tyrosine phosphatase activity
.phosphotyrosine binding
.cytoplasmic side of plasma membrane
.cytoskeleton
.cytoplasm
3 EBI-286357,EBI-447295 EP300  
  .negative regulation of protein stabilization
.regulation of cellular response to heat
.regulation of tubulin deacetylation
  + 40 more...
.pre-mRNA intronic binding
.androgen receptor binding
.nuclear hormone receptor binding
  + 17 more...
.cytoplasm
.transcription factor complex
.nucleoplasm
  + 2 more...
4 EBI-286357,EBI-632715 SNW1  
  .cellular response to retinoic acid
.positive regulation of vitamin D receptor signaling pathway
.regulation of vitamin D receptor signaling pathway
  + 19 more...
.SMAD binding
.poly(A) RNA binding
.retinoic acid receptor binding
  + 5 more...
.catalytic step 2 spliceosome
.nuclear matrix
.spliceosomal complex
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder33
blood40
bone27
brain7
cervix61
connective tissue46
eye9
heart67
intestine81
kidney37
lung56
lymph22
lymph node89
mammary gland33
mouth90
muscle18
ovary147
pancreas56
parathyroid1942
pharynx24
placenta35
prostate42
salivary gland49
skin61
stomach52
testis20
trachea77
uterus30
Health State
TissuesTPM*
normal27
breast (mammary gland) tumor21
cervical tumor57
chondrosarcoma36
colorectal tumor35
gastrointestinal tumor59
germ cell tumor11
glioma55
head and neck tumor52
leukemia52
lymphoma13
non-neoplasia41
ovarian tumor170
prostate cancer28
skin tumor31
uterine tumor44
Developmental Stage
TissuesTPM*
adult60
fetus26
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.8
adrenal gland10.8
appendix11.2
bone marrow4.6
colon32.5
duodenum45.7
esophagus7.8
gallbladder8.5
kidney19.9
lung6.1
lymph node4.6
placenta2.9
salivary gland2
skin15.8
small intestine45.1
spleen1.6
stomach7
testis1.3
thyroid gland1.3
urinary bladder6.5
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(#277440, phenotype) Vitamin d-dependent rickets, type 2a; VDDR2AOMIM
2(*601769, gene) Vitamin d receptor; VDROMIM
3(#607948, phenotype) Mycobacterium tuberculosis, susceptibility toOMIM


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