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> Protein (NX_P11532)
Protein (NX_P11532)
Protein
Gene SymbolDMD to neXtProt (NX_P11532)
DescriptionDystrophin
ChromosomeX
LocationXp21.1 (31115794 ~ 33357558) to Ensembl
Sequene Features : Isoforms 10, Variants 699, PTMs 16 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of sodium ion transmembrane transporter activity
.negative regulation of peptidyl-cysteine S-nitrosylation
.regulation of voltage-gated calcium channel activity
  + 23 more...
.nitric-oxide synthase binding
.vinculin binding
.myosin binding
  + 5 more...
.postsynaptic membrane
.synapse
.membrane raft
  + 15 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
10 699 16
2014-09-19protein level
10 554 16
2014-05-27protein level
10 552 16
2014-02-25protein level
10 550 16
2013-12-09protein level
10 490 16
2013-11-01protein level
10 470 15
2013-09-12protein level
10 470 15
2013-08-17protein level
10 470 15
2013-07-15protein level
10 318 15
2013-06-11protein level
10 318 15
2013-02-12protein level
6 159 72
2012-12-20protein level
6 153 72
2012-10-30protein level
6 182 72
2012-10-07protein level
6 182 13
2012-08-24protein level
6 135 13
2012-07-28protein level
6 135 13
2012-06-08protein level
6 52 13
2012-05-07protein level
6 52 13
2012-04-10protein level
5 52 13
2012-01-13protein level
5 52 13
2011-12-20protein level
5 52 13
2011-11-11protein level
5 52 10
2011-08-23protein level
5 51 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P11532-1
1 173 3 426483.0505
NX_P11532-10
0 22 3 57915.8327
NX_P11532-2
1 107 3 271221.5597
NX_P11532-3
0 107 3 270871.4265
NX_P11532-4
0 173 3 425374.5843
NX_P11532-5
0 27 3 70704.7589
NX_P11532-6
0 27 3 72144.4999
NX_P11532-7
0 26 3 70329.7376
NX_P11532-8
0 26 3 68889.9966
NX_P11532-9
0 23 3 59730.595
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-295827,EBI-740402 DTNB  
  .N/A .zinc ion binding .synapse
.cytoplasm
2 EBI-295827,EBI-742756 KRT19  
  .cell differentiation involved in embryonic placenta development
.sarcomere organization
.response to estrogen
.viral process
.structural constituent of muscle
.structural constituent of cytoskeleton
.cell periphery
.extracellular exosome
.costamere
  + 5 more...
3 EBI-1018651,EBI-941975 ANK2  
  .positive regulation of cation channel activity
.positive regulation of calcium ion transmembrane transporter activity
.regulation of calcium ion transmembrane transporter activity
  + 40 more...
.ATPase binding
.ion channel binding
.protein binding, bridging
  + 5 more...
.perinuclear region of cytoplasm
.postsynaptic membrane
.membrane raft
  + 15 more...
4 EBI-295827,EBI-295843 SNTB1  
  .muscle contraction .N/A .synapse
.protein complex
.sarcolemma
  + 4 more...
5 EBI-295827,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
6 EBI-295827,EBI-514206 CTNNAL1  
  .Rho protein signal transduction
.cell adhesion
.N/A .plasma membrane
.cytoskeleton
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bone27
brain58
cervix123
connective tissue20
ear186
embryonic tissue23
eye62
heart78
intestine51
kidney18
liver38
lung11
lymph node22
mammary gland6
mouth30
muscle159
nerve128
ovary29
pancreas23
pharynx49
pituitary gland60
placenta24
prostate68
skin18
spleen18
stomach20
testis25
thymus12
thyroid128
trachea173
uterus34
vascular77
Health State
TissuesTPM*
normal51
chondrosarcoma36
colorectal tumor62
gastrointestinal tumor8
germ cell tumor7
glioma27
head and neck tumor59
kidney tumor29
liver tumor31
non-neoplasia10
ovarian tumor65
pancreatic tumor19
prostate cancer57
skin tumor15
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult47
embryoid body28
blastocyst32
fetus80
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue20.6
adrenal gland17.8
appendix6.2
cerebral cortex14.6
colon10.4
duodenum6.9
esophagus14.3
gallbladder31.9
heart muscle49
kidney5.9
liver29.6
lung9.1
lymph node5.5
ovary15.6
pancreas29.8
placenta15.1
prostate15.9
salivary gland25.2
skin11.9
small intestine5.7
spleen2.5
stomach8.7
testis8.3
thyroid gland8.9
urinary bladder15.1
Tissues
TissuesExpression level
cerebral cortexLow
heart muscleMedium
skeletal muscleMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#300376, phenotype) Muscular dystrophy, becker type; BMDOMIM
2(*300377, gene) Dystrophin; DMDOMIM
3(#302045, phenotype) Cardiomyopathy, dilated, 3b; CMD3BOMIM
4(#310200, phenotype) Muscular dystrophy, duchenne type; DMDOMIM


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