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> Protein (NX_P11686)
Protein (NX_P11686)
Protein
Gene SymbolSFTPC to neXtProt (NX_P11686)
DescriptionPulmonary surfactant-associated protein C
Chromosome8
Location8p21.3 (22014426 ~ 22021992) to Ensembl
Sequene Features : Isoforms 2, Variants 34, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to nitric oxide
.cellular response to mechanical stimulus
.response to growth factor
  + 11 more...
.N/A .alveolar lamellar body
.multivesicular body
.extracellular space
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 34 4
2014-09-19protein level
2 28 4
2014-05-27protein level
2 28 3
2014-02-25protein level
2 28 3
2013-12-09protein level
2 19 3
2013-11-01protein level
2 18 3
2013-09-12protein level
2 18 3
2013-08-17protein level
2 18 3
2013-07-15protein level
2 12 3
2013-06-11protein level
2 12 3
2013-02-12protein level
2 11 7
2012-12-20protein level
2 9 6
2012-10-30protein level
2 11 6
2012-10-07protein level
2 11 3
2012-08-24protein level
2 10 3
2012-07-28protein level
2 10 3
2012-06-08protein level
2 10 3
2012-05-07protein level
2 10 3
2012-04-10protein level
2 10 3
2012-01-13protein level
2 10 3
2011-12-20protein level
2 11 3
2011-11-11protein level
2 11 3
2011-08-23protein level
2 11 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P11686-1
1 7 0 21038.7925
NX_P11686-2
1 7 0 20347.5273
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10197617,EBI-4402709 SEC61G  
  .protein targeting to ER
.cellular protein metabolic process
.antigen processing and presentation of exogenous peptide antigen via MHC class I
  + 7 more...
.P-P-bond-hydrolysis-driven protein transmembrane transporter activity
.protein transporter activity
.integral component of membrane
.membrane
.cytosol
.endoplasmic reticulum membrane
2 EBI-10197617,EBI-3911467 CXCL9  
  .positive regulation of myoblast fusion
.chemokine-mediated signaling pathway
.defense response to virus
  + 16 more...
.CXCR3 chemokine receptor binding
.chemokine activity
.cytokine activity
.external side of plasma membrane
.extracellular space
.extracellular region
3 EBI-10197617,EBI-7131783 SYNE4  
  .establishment of epithelial cell apical/basal polarity .N/A .LINC complex
.integral component of nuclear outer membrane
4 EBI-10197617,EBI-8652744 SEC22A  
  .vesicle fusion with Golgi apparatus
.protein transport
.ER to Golgi vesicle-mediated transport
.SNAP receptor activity
.transporter activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endoplasmic reticulum membrane
5 EBI-10197617,EBI-8649725 TMEM79  
  .cornification
.establishment of skin barrier
.positive regulation of epidermis development
  + 4 more...
.N/A .trans-Golgi network membrane
.integral component of membrane
.lysosomal membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
brain2
connective tissue1717
eye9
heart178
intestine17
kidney4
lung1618
nerve64
ovary19
pharynx73
testis6
Health State
TissuesTPM*
normal127
chondrosarcoma3090
colorectal tumor35
germ cell tumor7
lung tumor437
non-neoplasia921
ovarian tumor26
Developmental Stage
TissuesTPM*
adult269
fetus113
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adrenal gland28.1
appendix13.9
cerebral cortex5.2
duodenum1.4
esophagus3.5
liver2.9
lung8056.7
placenta4.9
prostate11.7
skin5.3
spleen14.3
stomach6.5
testis4.2
thyroid gland7.8
Tissues
TissuesExpression level
lungHigh
spleenLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*178620, gene) Surfactant, pulmonary-associated protein c; SFTPCOMIM
2(#267450, phenotype) Respiratory distress syndrome in premature infantsOMIM
3(#610913, phenotype) Surfactant metabolism dysfunction, pulmonary, 2; SMDP2OMIM


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