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> Protein (NX_P11940)
Protein (NX_P11940)
Protein
Gene SymbolPABPC1 to neXtProt (NX_P11940)
DescriptionPolyadenylate-binding protein 1
Chromosome8
Location8q22.3 (101698044 ~ 101735037) to Ensembl
Sequene Features : Isoforms 2, Variants 94, PTMs 26 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
.positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 12 more...
.poly(A) RNA binding
.translation activator activity
.poly(U) RNA binding
  + 4 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cytoplasmic ribonucleoprotein granule
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 94 26
2014-09-19protein level
2 71 26
2014-05-27protein level
2 71 49
2014-02-25protein level
2 69 42
2013-12-09protein level
2 54 42
2013-11-01protein level
2 54 31
2013-09-12protein level
2 54 32
2013-08-17protein level
2 54 32
2013-07-15protein level
2 35 18
2013-06-11protein level
2 35 18
2013-02-12protein level
2 15 29
2012-12-20protein level
2 15 29
2012-10-30protein level
2 16 29
2012-10-07protein level
2 16 17
2012-08-24protein level
2 13 17
2012-07-28protein level
2 13 17
2012-06-08protein level
2 18 17
2012-05-07protein level
2 18 17
2012-04-10protein level
2 18 17
2012-01-13protein level
2 36 17
2011-12-20protein level
2 36 17
2011-11-11protein level
2 36 15
2011-08-23protein level
2 36 13
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P11940-1
3 6 22 70625.6667
NX_P11940-2
1 6 22 61141.8643
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-81531,EBI-353779 DDX3X  
  .negative regulation of intrinsic apoptotic signaling pathway
.positive regulation of G1/S transition of mitotic cell cycle
.intrinsic apoptotic signaling pathway
  + 28 more...
.mRNA 5'-UTR binding
.poly(A) RNA binding
.CTPase activity
  + 14 more...
.extracellular exosome
.nuclear speck
.cytoplasmic stress granule
  + 4 more...
2 EBI-81531,EBI-9094806 GSPT1  
  .protein methylation
.translational termination
.nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
.G1/S transition of mitotic cell cycle
.poly(A) RNA binding
.GTP binding
.GTPase activity
.translation release factor activity
.intracellular
3 EBI-81531,EBI-517592 IRS1  
  .positive regulation of glucose import in response to insulin stimulus
.JAK-STAT cascade involved in growth hormone signaling pathway
.phosphatidylinositol-mediated signaling
  + 29 more...
.phosphatidylinositol 3-kinase binding
.SH2 domain binding
.insulin-like growth factor receptor binding
  + 4 more...
.intracellular membrane-bounded organelle
.ciliary basal body
.caveola
  + 5 more...
4 EBI-81531,EBI-723281 TOB1  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
.negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 6 more...
.receptor tyrosine kinase binding
.SH3/SH2 adaptor activity
.transcription corepressor activity
.CCR4-NOT complex
.cytoplasm
.nucleus
5 EBI-81531,EBI-73711 EIF4G1  
  .cellular protein metabolic process
.cytokine-mediated signaling pathway
.viral process
  + 8 more...
.poly(A) RNA binding
.translation factor activity, RNA binding
.translation initiation factor activity
.eukaryotic translation initiation factor 4F complex
.membrane
.cytosol
6 EBI-81531,EBI-432545 HNRNPD  
  .circadian regulation of translation
.positive regulation of transcription, DNA-templated
.positive regulation of translation
  + 9 more...
.poly(A) RNA binding
.telomeric DNA binding
.RNA binding
.nucleotide binding
.extracellular exosome
.ribonucleoprotein complex
.cytosol
  + 2 more...
7 EBI-81531,EBI-2562000 TOB2  
  .positive regulation of ossification
.negative regulation of osteoclast differentiation
.regulation of gene expression
  + 2 more...
.N/A .cytoplasm
.nucleus
8 EBI-81531,EBI-2513054 PAN3  
  .RNA phosphodiester bond hydrolysis, exonucleolytic
.positive regulation of cytoplasmic mRNA processing body assembly
.gene expression
  + 4 more...
.metal ion binding
.transferase activity, transferring phosphorus-containing groups
.ATP binding
.PAN complex
.cytosol
.cytoplasmic mRNA processing body
9 EBI-81531,EBI-3869637 GSPT2  
  .cellular protein metabolic process
.gene expression
.cell cycle
  + 3 more...
.poly(A) RNA binding
.GTP binding
.GTPase activity
.cytosol
10 EBI-81531,EBI-1049832 SMG1  
  .phosphatidylinositol phosphorylation
.protein autophosphorylation
.peptidyl-serine phosphorylation
  + 5 more...
.protein dimerization activity
.metal ion binding
.poly(A) RNA binding
  + 3 more...
.cytosol
.cytoplasm
.nucleus
11 EBI-81531,EBI-697691 ATXN2  
  .neuromuscular process
.RNA transport
.homeostasis of number of cells
  + 9 more...
.poly(A) RNA binding
.protein C-terminus binding
.epidermal growth factor receptor binding
.RNA binding
.perinuclear region of cytoplasm
.ribonucleoprotein complex
.membrane
  + 6 more...
12 EBI-81531,EBI-2957445 PAIP2  
  .regulation of long-term synaptic potentiation
.negative regulation of translational initiation
.memory
.spermatogenesis
.translation repressor activity
.mRNA binding
.cytoplasm
13 EBI-81531,EBI-81519 PAIP1  
  .mRNA stabilization
.positive regulation of translation
.gene expression
  + 3 more...
.translation activator activity
.RNA binding
.cytosol
.cytoplasm
14 EBI-81531,EBI-6507625 TNRC6C  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.regulation of gene silencing by miRNA
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
  + 13 more...
.RNA binding
.nucleotide binding
.cytosol
15 EBI-81531,EBI-947158 TNRC6B  
  .positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
.phosphatidylinositol-mediated signaling
  + 10 more...
.poly(A) RNA binding
.nucleotide binding
.cytosol
.cytoplasmic mRNA processing body
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland485
ascites953
bladder1239
blood744
bone1117
bone marrow1025
brain163
cervix763
connective tissue429
ear1801
embryonic tissue756
esophagus396
eye718
heart279
intestine1245
kidney379
larynx3110
liver453
lung430
lymph677
lymph node690
mammary gland1236
mouth544
muscle319
nerve386
ovary561
pancreas487
parathyroid145
pharynx1031
pituitary gland302
placenta190
prostate770
salivary gland789
skin721
spleen187
stomach1473
testis351
thymus138
thyroid772
tonsil1175
trachea115
umbilical cord217
uterus624
vascular735
Health State
TissuesTPM*
normal370
adrenal tumor869
bladder carcinoma2672
breast (mammary gland) tumor1117
cervical tumor1072
chondrosarcoma615
colorectal tumor2106
esophageal tumor463
gastrointestinal tumor1502
germ cell tumor661
glioma410
head and neck tumor1158
kidney tumor638
leukemia793
liver tumor635
lung tumor651
lymphoma914
non-neoplasia248
ovarian tumor630
pancreatic tumor666
primitive neuroectodermal tumor of the CNS393
prostate cancer1367
retinoblastoma1184
skin tumor701
soft tissue/muscle tissue tumor638
uterine tumor998
Developmental Stage
TissuesTPM*
adult713
embryoid body671
blastocyst667
neonate193
fetus366
infant255
juvenile593
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue377.7
adrenal gland200.4
appendix486.2
bone marrow501.8
cerebral cortex115.6
colon443.3
duodenum361.5
esophagus722
gallbladder311.8
heart muscle94.8
kidney157.2
liver164.4
lung246.1
lymph node592.9
ovary543.3
pancreas181.3
placenta244.7
prostate282.3
salivary gland857.7
skin419
small intestine331.5
spleen407.6
stomach450.1
testis443.2
thyroid gland260
urinary bladder567.2
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusHigh
fallopian tubeMedium
gallbladderMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasLow
parathyroid glandLow
placentaMedium
prostateMedium
rectumMedium
salivary glandMedium
seminal vesicleMedium
skin 1Medium
skin 2Medium
small intestineMedium
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2High
testisHigh
thyroid glandLow
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*604679, gene) Polyadenylate-binding protein, cytoplasmic, 1; PABPC1OMIM


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