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> Protein (NX_P12236)
Protein (NX_P12236)
Protein
Gene SymbolSLC25A6 to neXtProt (NX_P12236)
DescriptionADP/ATP translocase 3
ChromosomeX
LocationXp22.33 (1505045 ~ 1511617) to Ensembl
Sequene Features : Isoforms 1, Variants 29, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of insulin secretion
.active induction of host immune response by virus
.small molecule metabolic process
  + 9 more...
.ATP:ADP antiporter activity .integral component of membrane
.mitochondrial inner membrane presequence translocase complex
.mitochondrial inner membrane
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 29 10
2014-09-19protein level
1 15 10
2014-05-27protein level
1 15 15
2014-02-25protein level
1 15 13
2013-12-09protein level
1 15 13
2013-11-01protein level
1 15 5
2013-09-12protein level
1 15 5
2013-08-17protein level
1 15 5
2013-07-15protein level
1 11 5
2013-06-11protein level
1 11 5
2013-02-12protein level
1 4 7
2012-12-20protein level
1 2 7
2012-10-30protein level
1 5 7
2012-10-07protein level
1 5 11
2012-08-24protein level
1 5 11
2012-07-28protein level
1 5 11
2012-06-08protein level
1 5 11
2012-05-07protein level
1 5 11
2012-04-10protein level
1 5 11
2012-01-13protein level
1 6 11
2011-12-20protein level
1 6 11
2011-11-11protein level
1 6 11
2011-08-23protein level
1 6 8
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P12236-1
6 0 11 32845.0949
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-356254,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
2 EBI-356254,EBI-432924 AP2B1  
  .clathrin-mediated endocytosis
.regulation of defense response to virus by virus
.ephrin receptor signaling pathway
  + 8 more...
.clathrin binding
.protein transporter activity
.signal sequence binding
.intracellular membrane-bounded organelle
.clathrin-coated endocytic vesicle membrane
.endocytic vesicle membrane
  + 4 more...
3 EBI-356254,EBI-359224 TRAF1  
  .regulation of extrinsic apoptotic signaling pathway
.positive regulation of NF-kappaB transcription factor activity
.signal transduction
  + 2 more...
.thioesterase binding
.ubiquitin protein ligase binding
.zinc ion binding
.tumor necrosis factor receptor binding
.cytoplasm
4 EBI-356254,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
5 EBI-356254,EBI-742327 TRIP6  
  .focal adhesion assembly
.positive regulation of cell migration
.release of cytoplasmic sequestered NF-kappaB
  + 2 more...
.thyroid hormone receptor binding
.poly(A) RNA binding
.kinase binding
  + 2 more...
.focal adhesion
.plasma membrane
.cytoskeleton
  + 2 more...
6 EBI-356254,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
7 EBI-356254,EBI-5323863 LRRK2  
  .negative regulation of peroxidase activity
.regulation of synaptic vesicle exocytosis
.regulation of branching morphogenesis of a nerve
  + 64 more...
.protein kinase A binding
.ion channel binding
.protein homodimerization activity
  + 18 more...
.extracellular exosome
.membrane raft
.perikaryon
  + 25 more...
8 EBI-356254,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
9 EBI-356254,EBI-750487 TEKT4  
  .cell projection organization .N/A .motile cilium
.microtubule
.cytoplasm
.nucleus
10 EBI-356254,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
11 EBI-356254,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue1243
adrenal gland455
ascites853
bladder468
blood417
bone293
bone marrow697
brain369
cervix1608
connective tissue160
ear248
embryonic tissue1070
esophagus297
eye627
heart234
intestine547
kidney279
larynx596
liver871
lung973
lymph1557
lymph node278
mammary gland575
mouth468
muscle846
nerve708
ovary679
pancreas421
parathyroid291
pharynx270
pituitary gland1149
placenta325
prostate791
salivary gland1184
skin536
spleen206
stomach909
testis261
thymus263
thyroid429
tonsil528
trachea38
umbilical cord290
uterus504
vascular193
Health State
TissuesTPM*
normal373
adrenal tumor869
bladder carcinoma113
breast (mammary gland) tumor590
cervical tumor2000
chondrosarcoma217
colorectal tumor702
esophageal tumor289
gastrointestinal tumor818
germ cell tumor607
glioma708
head and neck tumor373
kidney tumor508
leukemia592
liver tumor1239
lung tumor2354
lymphoma1121
non-neoplasia165
ovarian tumor630
pancreatic tumor609
primitive neuroectodermal tumor of the CNS897
prostate cancer1251
retinoblastoma1119
skin tumor590
soft tissue/muscle tissue tumor981
uterine tumor665
Developmental Stage
TissuesTPM*
adult456
embryoid body728
blastocyst1318
neonate289
fetus323
infant808
juvenile269
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue153
adrenal gland135
appendix113.4
bone marrow160.4
cerebral cortex68
colon168.5
duodenum227.6
esophagus93.8
gallbladder87.2
heart muscle74.2
kidney199.4
liver36
lung89.4
lymph node144.1
ovary198
pancreas190
placenta93.1
prostate131
salivary gland320.3
skin89.9
small intestine184.8
spleen160.6
stomach165.2
testis48
thyroid gland132.5
urinary bladder101.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*300151, gene) Solute carrier family 25 (mitochondrial carrier, adenine nucleotideOMIM
2(*403000, gene) Adenine nucleotide translocator 3, y-chromosomal; ANT3YOMIM


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