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> Protein (NX_P12814)
Protein (NX_P12814)
Protein
Gene SymbolACTN1 to neXtProt (NX_P12814)
DescriptionAlpha-actinin-1
Chromosome14
Location14q24.1 (69340860 ~ 69446157) to Ensembl
Sequene Features : Isoforms 4, Variants 98, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of nucleic acid-templated transcription
.actin crosslink formation
.negative regulation of cellular component movement
  + 8 more...
.ion channel binding
.ligand-dependent nuclear receptor transcription coactivator activity
.vinculin binding
  + 3 more...
.extracellular exosome
.dendritic spine
.cell projection
  + 14 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
4 98 11
2014-09-19protein level
4 76 11
2014-05-27protein level
4 76 20
2014-02-25protein level
4 75 20
2013-12-09protein level
4 60 20
2013-11-01protein level
4 59 16
2013-09-12protein level
4 55 16
2013-08-17protein level
3 53 16
2013-07-15protein level
3 28 15
2013-06-11protein level
3 28 15
2013-02-12protein level
3 14 33
2012-12-20protein level
3 14 33
2012-10-30protein level
3 16 33
2012-10-07protein level
3 16 11
2012-08-24protein level
3 9 11
2012-07-28protein level
3 9 11
2012-06-08protein level
3 17 11
2012-05-07protein level
3 17 11
2012-04-10protein level
2 17 11
2012-01-13protein level
2 25 11
2011-12-20protein level
2 25 11
2011-11-11protein level
2 25 8
2011-08-23protein level
2 25 9
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P12814-1
1 30 21 102992.3405
NX_P12814-2
0 31 21 102644.1119
NX_P12814-3
1 32 21 105501.4271
NX_P12814-4
2 30 21 107073.3997
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-351710,EBI-3932815 OAS1  
  .regulation of ribonuclease activity
.type I interferon signaling pathway
.interferon-gamma-mediated signaling pathway
  + 9 more...
.metal ion binding
.zinc ion binding
.ATP binding
  + 2 more...
.cytosol
.endoplasmic reticulum
.mitochondrion
  + 3 more...
2 EBI-351710,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
3 EBI-351710,EBI-6255981 EPM2AIP1  
  .positive regulation of glycogen (starch) synthase activity
.positive regulation of glycogen biosynthetic process
.response to insulin
.N/A .endoplasmic reticulum
.nucleus
4 EBI-351710,EBI-2555563 MICALL2  
  .positive regulation of protein targeting to mitochondrion
.tight junction assembly
.substrate adhesion-dependent cell spreading
  + 5 more...
.actin filament binding
.filamin binding
.zinc ion binding
.recycling endosome
.neuron projection
.tight junction
  + 4 more...
5 EBI-351710,EBI-741724 SPERT  
  .N/A .N/A .cytoplasmic membrane-bounded vesicle
6 EBI-351710,EBI-2511344 KCTD6  
  .protein homooligomerization .ankyrin binding .N/A
7 EBI-351710,EBI-681210 TTN  
  .cardiac muscle contraction
.cardiac muscle tissue morphogenesis
.cardiac myofibril assembly
  + 18 more...
.structural molecule activity conferring elasticity
.muscle alpha-actinin binding
.actin filament binding
  + 13 more...
.extracellular exosome
.I band
.M band
  + 5 more...
8 EBI-351710,EBI-746712 MYOZ2  
  .N/A .telethonin binding
.protein phosphatase 2B binding
.Z disc
.sarcomere
.actin cytoskeleton
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue388
adrenal gland60
ascites75
bladder133
blood261
bone307
bone marrow205
brain220
cervix247
connective tissue328
ear124
embryonic tissue596
esophagus148
eye172
heart156
intestine340
kidney370
larynx213
liver228
lung307
lymph node55
mammary gland343
mouth650
muscle188
nerve128
ovary197
pancreas267
parathyroid48
pharynx49
placenta215
prostate242
salivary gland197
skin488
spleen206
stomach209
testis257
thymus313
thyroid236
trachea424
umbilical cord72
uterus456
vascular309
Health State
TissuesTPM*
normal229
adrenal tumor79
bladder carcinoma170
breast (mammary gland) tumor300
cervical tumor144
chondrosarcoma494
colorectal tumor382
esophageal tumor115
gastrointestinal tumor227
germ cell tumor349
glioma205
head and neck tumor396
kidney tumor392
leukemia338
liver tumor385
lung tumor282
lymphoma13
non-neoplasia175
ovarian tumor183
pancreatic tumor476
primitive neuroectodermal tumor of the CNS307
prostate cancer202
retinoblastoma64
skin tumor406
soft tissue/muscle tissue tumor407
uterine tumor277
Developmental Stage
TissuesTPM*
adult265
embryoid body1057
blastocyst569
neonate418
fetus168
infant85
juvenile197
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue107.6
adrenal gland44.8
appendix150.6
bone marrow119.1
cerebral cortex41.6
colon118.5
duodenum47.6
esophagus145.2
gallbladder168.8
heart muscle96.8
kidney23.1
liver39.3
lung67.3
lymph node48.7
ovary36.7
pancreas23.6
placenta100
prostate152.6
salivary gland83
skin17.4
small intestine51.6
spleen57.1
stomach45.1
testis32.7
thyroid gland31.4
urinary bladder199.5
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*102575, gene) Actinin, alpha-1; ACTN1OMIM


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