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> Protein (NX_P12931)
Protein (NX_P12931)
Protein
Gene SymbolSRC to neXtProt (NX_P12931)
DescriptionProto-oncogene tyrosine-protein kinase Src
Chromosome20
Location20q11.23 (35973088 ~ 36034453) to Ensembl
Sequene Features : Isoforms 2, Variants 39, PTMs 13 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 39 13
2014-09-19protein level
2 26 13
2014-05-27protein level
2 26 13
2014-02-25protein level
2 25 13
2013-12-09protein level
2 24 13
2013-11-01protein level
2 22 12
2013-09-12protein level
2 22 13
2013-08-17protein level
2 22 13
2013-07-15protein level
2 17 13
2013-06-11protein level
2 17 13
2013-02-12protein level
2 6 26
2012-12-20protein level
2 6 26
2012-10-30protein level
2 6 26
2012-10-07protein level
2 6 13
2012-08-24protein level
2 5 13
2012-07-28protein level
2 5 13
2012-06-08protein level
2 6 13
2012-05-07protein level
2 4 13
2012-04-10protein level
2 4 13
2012-01-13protein level
2 5 13
2011-12-20protein level
2 5 13
2011-11-11protein level
2 5 14
2011-08-23protein level
2 5 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P12931-1
1 19 6 59796.8236
NX_P12931-2
2 19 6 60550.282
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-621482,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
2 EBI-621482,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
3 EBI-621482,EBI-78473 ESR1  
  .cellular response to estradiol stimulus
.epithelial cell proliferation involved in mammary gland duct elongation
.mammary gland alveolus development
  + 33 more...
.ATPase binding
.identical protein binding
.estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
  + 14 more...
.transcriptionally active chromatin
.integral component of membrane
.membrane
  + 5 more...
4 EBI-621482,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
5 EBI-621482,EBI-491169 ADRB2  
  .activation of mitophagy in response to mitochondrial depolarization
.adenylate cyclase-activating adrenergic receptor signaling pathway
.brown fat cell differentiation
  + 21 more...
.norepinephrine binding
.epinephrine binding
.protein homodimerization activity
  + 2 more...
.receptor complex
.apical plasma membrane
.integral component of plasma membrane
  + 4 more...
6 EBI-621482,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
7 EBI-621482,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
8 EBI-621482,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
9 EBI-621482,EBI-351710 ACTN1  
  .regulation of nucleic acid-templated transcription
.actin crosslink formation
.negative regulation of cellular component movement
  + 8 more...
.ion channel binding
.ligand-dependent nuclear receptor transcription coactivator activity
.vinculin binding
  + 3 more...
.extracellular exosome
.dendritic spine
.cell projection
  + 14 more...
10 EBI-621482,EBI-727477 CDH1  
  .regulation of neuron migration
.regulation of protein localization to cell surface
.cochlea development
  + 39 more...
.cell adhesion molecule binding
.gamma-catenin binding
.GTPase activating protein binding
  + 4 more...
.extracellular exosome
.perinuclear region of cytoplasm
.apical part of cell
  + 21 more...
11 EBI-621482,EBI-913224 ETS1  
  .response to interleukin-1
.cellular response to hydrogen peroxide
.angiogenesis involved in wound healing
  + 24 more...
.sequence-specific DNA binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.intercellular bridge
.cytoplasm
.transcription factor complex
  + 2 more...
12 EBI-621482,EBI-716404 PECAM1  
  .glomerular endothelium development
.diapedesis
.leukocyte migration
  + 8 more...
.N/A .extracellular exosome
.platelet alpha granule membrane
.cell junction
  + 3 more...
13 EBI-621482,EBI-968788 PTPN1  
  .positive regulation of receptor catabolic process
.peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
.negative regulation of PERK-mediated unfolded protein response
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.receptor tyrosine kinase binding
  + 4 more...
.cytoplasmic side of endoplasmic reticulum membrane
.sorting endosome
.cytoplasmic vesicle
  + 3 more...
14 EBI-621482,EBI-2609645 PTPRA  
  .peptidyl-tyrosine dephosphorylation
.insulin receptor signaling pathway
.axon guidance
.protein phosphorylation
.transmembrane receptor protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.extracellular exosome
.receptor complex
.integral component of plasma membrane
.plasma membrane
15 EBI-621482,EBI-720706 ERBB3  
  .extrinsic apoptotic signaling pathway in absence of ligand
.positive regulation of protein tyrosine kinase activity
.neuron apoptotic process
  + 21 more...
.protein heterodimerization activity
.protein homodimerization activity
.identical protein binding
  + 5 more...
.receptor complex
.lateral plasma membrane
.apical plasma membrane
  + 4 more...
16 EBI-621482,EBI-518228 CBL  
  .positive regulation of receptor-mediated endocytosis
.negative regulation of apoptotic process
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.ubiquitin protein ligase activity
.ephrin receptor binding
.SH3 domain binding
  + 6 more...
.flotillin complex
.plasma membrane
.cytosol
  + 2 more...
17 EBI-621482,EBI-494743 FAS  
  .positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
.necroptotic signaling pathway
  + 39 more...
.identical protein binding
.kinase binding
.transmembrane signaling receptor activity
  + 2 more...
.extracellular exosome
.membrane raft
.CD95 death-inducing signaling complex
  + 8 more...
18 EBI-621482,EBI-352398 RPL10  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.poly(A) RNA binding
.structural constituent of ribosome
.cytosolic large ribosomal subunit
.membrane
.cytosol
.endoplasmic reticulum
19 EBI-621482,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
20 EBI-621482,EBI-1047940 SPRR2A  
  .keratinization
.keratinocyte differentiation
.epidermis development
.N/A .cytoplasm
.cornified envelope
21 EBI-621482,EBI-1005487 KDR  
  .positive regulation of vasculogenesis
.negative regulation of endothelial cell apoptotic process
.positive regulation of ERK1 and ERK2 cascade
  + 39 more...
.Hsp90 protein binding
.vascular endothelial growth factor binding
.growth factor binding
  + 6 more...
.sorting endosome
.membrane raft
.cell junction
  + 10 more...
22 EBI-621482,EBI-1102694 ABL2  
  .negative regulation of endothelial cell apoptotic process
.regulation of actin cytoskeleton reorganization
.regulation of cell motility
  + 41 more...
.actin filament binding
.manganese ion binding
.ATP binding
  + 6 more...
.dendritic spine
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
  + 3 more...
23 EBI-621482,EBI-365875 MLLT4  
  .establishment of endothelial intestinal barrier
.cell-cell junction organization
.positive regulation of GTPase activity
  + 5 more...
.Ras GTPase binding
.protein C-terminus binding
.apical part of cell
.cell junction
.cell-cell adherens junction
  + 5 more...
24 EBI-621482,EBI-702093 BCAR1  
  .cell chemotaxis
.cell division
.B cell receptor signaling pathway
  + 21 more...
.protein kinase binding
.signal transducer activity
.lamellipodium
.actin cytoskeleton
.focal adhesion
  + 5 more...
25 EBI-621482,EBI-304185 HNRNPK  
  .regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
.positive regulation of receptor-mediated endocytosis
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.poly(A) RNA binding
.RNA binding
.single-stranded DNA binding
  + 2 more...
.catalytic step 2 spliceosome
.extracellular exosome
.cell projection
  + 7 more...
26 EBI-621482,EBI-6082337 ROR1  
  .peptidyl-tyrosine phosphorylation
.transmembrane receptor protein tyrosine kinase signaling pathway
.Wnt-protein binding
.ATP binding
.transmembrane receptor protein tyrosine kinase activity
.receptor complex
.integral component of plasma membrane
.plasma membrane
.cytoplasm
27 EBI-621482,EBI-702142 PTK2  
  .negative regulation of anoikis
.positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.regulation of substrate adhesion-dependent cell spreading
  + 56 more...
.SH2 domain binding
.protein kinase binding
.JUN kinase binding
  + 7 more...
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
.apical plasma membrane
  + 9 more...
28 EBI-621482,EBI-1364 KHDRBS1  
  .positive regulation of RNA export from nucleus
.regulation of RNA export from nucleus
.positive regulation of translational initiation
  + 8 more...
.poly(A) RNA binding
.identical protein binding
.poly(U) RNA binding
  + 4 more...
.Grb2-Sos complex
.membrane
.cytoplasm
  + 2 more...
29 EBI-621482,EBI-1045887 PAK2  
  .negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
.positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of protein tyrosine kinase activity
  + 30 more...
.Rac GTPase binding
.identical protein binding
.protein tyrosine kinase activator activity
  + 4 more...
.perinuclear region of cytoplasm
.plasma membrane
.cytosol
  + 2 more...
30 EBI-621482,EBI-77818 ADAM15  
  .negative regulation of receptor binding
.protein kinase C signaling
.cardiac epithelial to mesenchymal transition
  + 11 more...
.SH3 domain binding
.zinc ion binding
.metallopeptidase activity
  + 2 more...
.extracellular exosome
.cell projection
.integral component of membrane
  + 4 more...
31 EBI-621482,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
32 EBI-621482,EBI-976876 RAPGEF1  
  .negative regulation of neural precursor cell proliferation
.cellular response to nerve growth factor stimulus
.regulation of cell junction assembly
  + 17 more...
.Rap guanyl-nucleotide exchange factor activity .cytosol
.early endosome
.endosome
33 EBI-621482,EBI-298640 PTK2B  
  .positive regulation of B cell chemotaxis
.positive regulation of excitatory postsynaptic membrane potential
.positive regulation of reactive oxygen species metabolic process
  + 84 more...
.ATP binding
.receptor binding
.N-methyl-D-aspartate selective glutamate receptor activity
  + 4 more...
.apical dendrite
.perinuclear region of cytoplasm
.membrane raft
  + 16 more...
34 EBI-621482,EBI-2860264 PTPN21  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.protein tyrosine phosphatase activity .cytoskeleton
.cytoplasm
35 EBI-621482,EBI-1220488 TNS3  
  .lung alveolus development
.cell migration
.positive regulation of cell proliferation
.N/A .focal adhesion
.cytoplasm
36 EBI-621482,EBI-724767 FBXO18  
  .positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.response to intra-S DNA damage checkpoint signaling
.positive regulation of protein phosphorylation
.DNA catabolic process, endonucleolytic
.ATP binding
.ATP-dependent DNA helicase activity
.DNA binding
.nucleus
37 EBI-621482,EBI-739832 LNX1  
  .protein homooligomerization
.protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.cytoplasm
38 EBI-621482,EBI-79893 PIK3R3  
  .phosphatidylinositol phosphorylation
.small molecule metabolic process
.regulation of phosphatidylinositol 3-kinase activity
  + 4 more...
.1-phosphatidylinositol-3-kinase regulator activity
.1-phosphatidylinositol-3-kinase activity
.phosphatidylinositol 3-kinase complex
.cytosol
39 EBI-621482,EBI-1393949 SRCIN1  
  .negative regulation of protein tyrosine kinase activity
.positive regulation of protein tyrosine kinase activity
.regulation of dendritic spine morphogenesis
  + 3 more...
.protein kinase binding .postsynaptic membrane
.synapse
.dendrite
  + 5 more...
40 EBI-621482,EBI-514199 MED28  
  .negative regulation of smooth muscle cell differentiation
.stem cell maintenance
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cortical actin cytoskeleton
.mediator complex
.membrane
41 EBI-621482,EBI-346622 ASAP1  
  .cilium morphogenesis
.organelle organization
.zinc ion binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.GTPase activator activity
.membrane
.cytosol
42 EBI-621482,EBI-81279 IKBKG  
  .negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
.negative regulation of neuron death
.nucleotide-binding oligomerization domain containing signaling pathway
  + 35 more...
.linear polyubiquitin binding
.K63-linked polyubiquitin binding
.protein heterodimerization activity
  + 5 more...
.mitotic spindle
.IkappaB kinase complex
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
ascites50
bladder133
blood8
bone55
brain12
embryonic tissue32
eye9
intestine43
kidney23
larynx42
liver4
lung65
lymph node11
mouth45
muscle28
nerve64
ovary29
pancreas42
placenta14
prostate36
skin56
stomach41
testis50
thyroid64
trachea19
umbilical cord145
uterus38
Health State
TissuesTPM*
normal16
bladder carcinoma56
chondrosarcoma36
colorectal tumor62
gastrointestinal tumor59
germ cell tumor30
glioma46
head and neck tumor52
kidney tumor14
leukemia10
liver tumor10
lung tumor68
ovarian tumor39
pancreatic tumor47
primitive neuroectodermal tumor of the CNS7
prostate cancer9
skin tumor55
soft tissue/muscle tissue tumor15
uterine tumor55
Developmental Stage
TissuesTPM*
adult26
embryoid body57
blastocyst32
fetus12
juvenile17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.3
adrenal gland24.7
appendix19.3
bone marrow10.6
cerebral cortex11.7
colon36.4
duodenum50.1
esophagus21.7
gallbladder45.4
heart muscle4.9
kidney20.2
liver6.5
lung25.3
lymph node8
ovary15.9
pancreas17.5
placenta13.8
prostate33.5
salivary gland9
skin17.4
small intestine48.8
spleen21.9
stomach58.7
testis37.5
thyroid gland7.6
urinary bladder36.4
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*190090, gene) V-src avian sarcoma (schmidt-ruppin a-2) viral oncogene; SRCOMIM


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