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> Protein (NX_P12956)
Protein (NX_P12956)
Protein
Gene SymbolXRCC6 to neXtProt (NX_P12956)
DescriptionX-ray repair cross-complementing protein 6
Chromosome22
Location22q13.2 (42017123 ~ 42060044) to Ensembl
Sequene Features : Isoforms 2, Variants 62, PTMs 30 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.establishment of integrated proviral latency
.cellular response to X-ray
.cellular hyperosmotic salinity response
  + 16 more...
.5'-deoxyribose-5-phosphate lyase activity
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 7 more...
.nonhomologous end joining complex
.Ku70:Ku80 complex
.membrane
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 62 30
2014-09-19protein level
1 52 30
2014-05-27protein level
1 52 30
2014-02-25protein level
1 52 30
2013-12-09protein level
1 48 30
2013-11-01protein level
1 44 22
2013-09-12protein level
1 44 22
2013-08-17protein level
1 44 22
2013-07-15protein level
1 26 14
2013-06-11protein level
1 26 14
2013-02-12protein level
1 9 16
2012-12-20protein level
1 9 16
2012-10-30protein level
1 9 16
2012-10-07protein level
1 9 16
2012-08-24protein level
1 9 16
2012-07-28protein level
1 9 16
2012-06-08protein level
1 19 16
2012-05-07protein level
1 14 16
2012-04-10protein level
1 14 16
2012-01-13protein level
1 23 16
2011-12-20protein level
1 23 16
2011-11-11protein level
1 23 14
2011-08-23protein level
1 23 13
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P12956-1
3 25 0 69798.8554
NX_P12956-2
1 25 0 65107.4014
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-353208,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-353208,EBI-357997 XRCC5  
  .establishment of integrated proviral latency
.cellular response to X-ray
.cellular hyperosmotic salinity response
  + 17 more...
.poly(A) RNA binding
.transcription regulatory region DNA binding
.telomeric DNA binding
  + 7 more...
.nonhomologous end joining complex
.Ku70:Ku80 complex
.membrane
  + 7 more...
3 EBI-353208,EBI-945751 COIL  
  .N/A .identical protein binding
.protein C-terminus binding
.membrane
.Cajal body
.cytoplasm
  + 3 more...
4 EBI-353208,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
5 EBI-353208,EBI-352053 PRKDC  
  .signal transduction involved in mitotic G1 DNA damage checkpoint
.rhythmic process
.positive regulation of transcription from RNA polymerase II promoter
  + 27 more...
.poly(A) RNA binding
.transcription factor binding
.ATP binding
  + 4 more...
.nonhomologous end joining complex
.membrane
.DNA-dependent protein kinase-DNA ligase 4 complex
  + 4 more...
6 EBI-353208,EBI-516580 BAX  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of extrinsic apoptotic signaling pathway in absence of ligand
.negative regulation of apoptotic signaling pathway
  + 87 more...
.BH3 domain binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.BAX complex
.Bcl-2 family protein complex
.extracellular exosome
  + 10 more...
7 EBI-353208,EBI-716596 PPID  
  .cellular response to UV-A
.chaperone-mediated protein folding
.positive regulation of protein secretion
  + 9 more...
.Hsp90 protein binding
.heat shock protein binding
.Hsp70 protein binding
  + 4 more...
.cytoplasm
.nucleolus
.nucleoplasm
.nucleus
8 EBI-353208,EBI-368417 WRN  
  .nucleic acid phosphodiester bond hydrolysis
.cellular response to gamma radiation
.positive regulation of hydrolase activity
  + 23 more...
.G-quadruplex DNA binding
.ATP-dependent 3'-5' DNA helicase activity
.3'-5' DNA helicase activity
  + 15 more...
.centrosome
.nucleolus
.nucleoplasm
9 EBI-353208,EBI-2549423 HMBOX1  
  .positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
.transcription, DNA-templated
.DNA binding .cytoplasm
.nucleoplasm
.nucleus
10 EBI-353208,EBI-716486 NDRG1  
  .positive regulation of spindle checkpoint
.cellular response to hypoxia
.mast cell activation
  + 3 more...
.cadherin binding
.gamma-tubulin binding
.Rab GTPase binding
.microtubule binding
.extracellular exosome
.recycling endosome membrane
.perinuclear region of cytoplasm
  + 8 more...
11 EBI-353208,EBI-1802965 SIRT1  
  .positive regulation of cellular senescence
.negative regulation of cellular senescence
.negative regulation of peptidyl-lysine acetylation
  + 102 more...
.keratin filament binding
.NAD+ binding
.mitogen-activated protein kinase binding
  + 17 more...
.rDNA heterochromatin
.PML body
.mitochondrion
  + 10 more...
12 EBI-353208,EBI-710003 ARAP1  
  .negative regulation of stress fiber assembly
.positive regulation of filopodium assembly
.regulation of cellular component movement
  + 6 more...
.zinc ion binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.GTPase activator activity
.Golgi cisterna membrane
.cytoplasmic vesicle
.plasma membrane
  + 3 more...
13 EBI-353208,EBI-924724 TCF7L2  
  .negative regulation of extrinsic apoptotic signaling pathway
.negative regulation of type B pancreatic cell apoptotic process
.insulin metabolic process
  + 57 more...
.armadillo repeat domain binding
.gamma-catenin binding
.transcription regulatory region DNA binding
  + 9 more...
.beta-catenin-TCF7L2 complex
.protein-DNA complex
.PML body
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland1548
ascites50
bladder33
blood65
bone335
bone marrow41
brain10
cervix20
connective tissue690
ear62
embryonic tissue14
esophagus2679
eye23
heart55
intestine30
kidney4
larynx42
liver24
lung14
lymph564
lymph node178
mammary gland59
mouth226
muscle752
nerve64
ovary522
pancreas51
parathyroid145
pharynx491
pituitary gland121
placenta52
prostate31
salivary gland148
skin94
spleen1048
stomach10
testis27
thymus1468
thyroid42
tonsil587
trachea521
umbilical cord1525
uterus17
vascular2265
Health State
TissuesTPM*
normal15
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma12
colorectal tumor53
esophageal tumor3015
gastrointestinal tumor25
germ cell tumor49
glioma18
head and neck tumor164
kidney tumor14
leukemia74
liver tumor52
lung tumor29
lymphoma41
non-neoplasia20
ovarian tumor511
pancreatic tumor57
primitive neuroectodermal tumor of the CNS62
prostate cancer48
retinoblastoma21
skin tumor143
soft tissue/muscle tissue tumor7
uterine tumor22
Developmental Stage
TissuesTPM*
adult39
embryoid body385
blastocyst716
neonate32
fetus10
infant42
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue86.6
adrenal gland100.9
appendix94.7
bone marrow82.3
cerebral cortex66.1
colon100.5
duodenum75.9
esophagus92.9
gallbladder70.7
heart muscle78
kidney84.7
liver57.8
lung70.2
lymph node112.3
ovary98.7
pancreas34.7
placenta94
prostate78.1
salivary gland55
skin71.8
small intestine78.2
spleen71.3
stomach75.5
testis144.5
thyroid gland83.4
urinary bladder92.4
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastHigh
bronchusHigh
cerebellumHigh
cerebral cortexMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1High
endometrium 2High
epididymisHigh
esophagusHigh
fallopian tubeHigh
gallbladderHigh
heart muscleHigh
hippocampusMedium
kidneyHigh
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryHigh
pancreasHigh
parathyroid glandMedium
placentaHigh
prostateHigh
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2High
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*152690, gene) X-ray repair, complementing defective, in chinese hamster, 6; XRCC6OMIM


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