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> Protein (NX_P13196)
Protein (NX_P13196)
Protein
Gene SymbolALAS1 to neXtProt (NX_P13196)
Description5-aminolevulinate synthase, nonspecific, mitochondrial
Chromosome3
Location3p21.2 (52232102 ~ 52248343) to Ensembl
Sequene Features : Isoforms 2, Variants 69, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.small molecule metabolic process
.cellular lipid metabolic process
.mitochondrion organization
  + 4 more...
.pyridoxal phosphate binding
.5-aminolevulinate synthase activity
.mitochondrial matrix
.mitochondrion
.cytoplasm
.nucleoplasm
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 69 2
2014-09-19protein level
2 53 2
2014-05-27protein level
2 53 2
2014-02-25protein level
2 52 2
2013-12-09protein level
2 38 2
2013-11-01protein level
2 34 2
2013-09-12protein level
2 34 2
2013-08-17protein level
2 34 2
2013-07-15protein level
2 25 1
2013-06-11protein level
2 25 1
2013-02-12protein level
2 14 1
2012-12-20protein level
2 14 1
2012-10-30protein level
2 19 1
2012-10-07protein level
2 19 1
2012-08-24protein level
2 19 1
2012-07-28protein level
2 19 1
2012-06-08protein level
2 6 1
2012-05-07protein level
2 6 1
2012-04-10protein level
2 6 1
2012-01-13protein level
2 6 1
2011-12-20protein level
2 8 1
2011-11-11protein level
2 8 1
2011-08-23protein level
2 8 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P13196-1
27 5 0 70535.3298
NX_P13196-2
3 5 0 12952.6141
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-3905054,EBI-346356 WIPF1  
  .response to other organism
.innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
  + 4 more...
.profilin binding
.actin binding
.cytoplasmic membrane-bounded vesicle
.actin cytoskeleton
.actin filament
  + 2 more...
2 EBI-3905054,EBI-368321 PPL  
  .keratinization .structural constituent of cytoskeleton .extracellular exosome
.desmosome
.plasma membrane
  + 3 more...
3 EBI-3905054,EBI-2688673 TMSB10  
  .sequestering of actin monomers
.actin filament organization
.N/A .cytoskeleton
.cytoplasm
4 EBI-3905054,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
5 EBI-3905054,EBI-10238588 FAM127C  
  .N/A .N/A .N/A
6 EBI-3905054,EBI-2341787 LONRF1  
  .N/A .zinc ion binding
.ATP-dependent peptidase activity
.N/A
7 EBI-3905054,EBI-359917 BCL7A  
  .negative regulation of transcription, DNA-templated .N/A .N/A
8 EBI-3905054,EBI-6447954 TTC23  
  .N/A .N/A .N/A
9 EBI-3905054,EBI-930143 CDC73  
  .negative regulation of G1/S transition of mitotic cell cycle
.cellular response to lipopolysaccharide
.negative regulation of epithelial cell proliferation
  + 17 more...
.RNA polymerase II core binding .Cdc73/Paf1 complex
.nucleoplasm
.nucleus
10 EBI-3905054,EBI-10252703 MTFR2  
  .aerobic respiration
.mitochondrion organization
.mitochondrial fission
.N/A .mitochondrion
11 EBI-3905054,EBI-9477654 KLHL35  
  .N/A .N/A .N/A
12 EBI-3905054,EBI-744896 SNX20  
  .protein transport .phosphatidylinositol binding .endosome membrane
.plasma membrane
.nucleus
13 EBI-3905054,EBI-10273713 ZNF564  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
14 EBI-3905054,EBI-10274247 CERK  
  .lipid phosphorylation
.small molecule metabolic process
.protein kinase C-activating G-protein coupled receptor signaling pathway
  + 3 more...
.ATP binding
.diacylglycerol kinase activity
.NAD+ kinase activity
  + 2 more...
.integral component of membrane
.plasma membrane
.mitochondrion
15 EBI-3905054,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
16 EBI-3905054,EBI-8654968 DUSP19  
  .positive regulation of JNK cascade
.negative regulation of JNK cascade
.positive regulation of protein kinase activity
  + 7 more...
.mitogen-activated protein kinase kinase kinase binding
.protein kinase activator activity
.JUN kinase phosphatase activity
  + 4 more...
.cytoplasm
17 EBI-3905054,EBI-750487 TEKT4  
  .cell projection organization .N/A .motile cilium
.microtubule
.cytoplasm
.nucleus
18 EBI-3905054,EBI-399163 EP400  
  .histone H2A acetylation
.histone H4 acetylation
.chromatin organization
.ATP binding
.helicase activity
.chromatin binding
.DNA binding
.NuA4 histone acetyltransferase complex
.nuclear speck
.nucleoplasm
.Swr1 complex
19 EBI-3905054,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
20 EBI-3905054,EBI-746682 GNL3L  
  .ribosome biogenesis
.metabolic process
.poly(A) RNA binding
.GTP binding
.GTPase activity
.membrane
.mitochondrion
.cytoplasm
  + 3 more...
21 EBI-3905054,EBI-2812028 C2orf42  
  .N/A .N/A .nuclear membrane
.nucleoplasm
.nucleus
22 EBI-3905054,EBI-2511991 USP20  
  .protein K48-linked deubiquitination
.protein K63-linked deubiquitination
.regulation of proteasomal protein catabolic process
  + 4 more...
.zinc ion binding
.ubiquitin-specific protease activity
.cysteine-type endopeptidase activity
.G-protein coupled receptor binding
.perinuclear region of cytoplasm
.centrosome
23 EBI-3905054,EBI-713000 POLDIP2  
  .mitochondrion morphogenesis .DNA binding .mitochondrial nucleoid
.mitochondrion
.nucleus
24 EBI-3905054,EBI-3438881 ZNF175  
  .defense response to virus
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.intermediate filament cytoskeleton
.cytoplasm
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland698
ascites25
bladder66
blood278
bone69
bone marrow82
brain99
cervix123
connective tissue127
embryonic tissue93
esophagus148
eye52
heart89
intestine81
kidney61
liver82
lung83
lymph135
lymph node122
mammary gland39
mouth45
muscle112
ovary78
pancreas51
pharynx122
placenta77
prostate47
skin61
spleen18
stomach125
testis32
thymus62
thyroid21
tonsil58
trachea96
uterus77
vascular193
Health State
TissuesTPM*
normal90
adrenal tumor316
breast (mammary gland) tumor42
cervical tumor115
chondrosarcoma72
colorectal tumor53
esophageal tumor115
gastrointestinal tumor118
germ cell tumor72
glioma55
head and neck tumor14
kidney tumor87
leukemia254
liver tumor83
lung tumor38
lymphoma138
non-neoplasia103
ovarian tumor65
pancreatic tumor28
primitive neuroectodermal tumor of the CNS62
prostate cancer38
retinoblastoma86
skin tumor39
soft tissue/muscle tissue tumor183
uterine tumor66
Developmental Stage
TissuesTPM*
adult79
embryoid body100
blastocyst32
neonate64
fetus96
infant85
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue25.2
adrenal gland464.5
appendix22
bone marrow84.4
cerebral cortex20.7
colon37.8
duodenum38.1
esophagus29.5
gallbladder32.5
heart muscle75.6
kidney28
liver367.9
lung42.5
lymph node21.1
ovary12.4
pancreas7.4
placenta33.9
prostate20.4
salivary gland29.9
skin15.8
small intestine34.1
spleen13.4
stomach30.3
testis20.6
thyroid gland20.9
urinary bladder46.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexHigh
cervix, uterineMedium
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleMedium
skin 1Medium
skin 2Medium
small intestineHigh
smooth muscleMedium
soft tissue 1Medium
soft tissue 2Medium
spleenLow
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*125290, gene) Delta-aminolevulinate synthase 1; ALAS1OMIM


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2014-2019 (C) Yonsei Proteome Research Center