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> Protein (NX_P13569)
Protein (NX_P13569)
Protein
Gene SymbolCFTR to neXtProt (NX_P13569)
DescriptionCystic fibrosis transmembrane conductance regulator
Chromosome7
Location7q31.2 (117105838 ~ 117356025) to Ensembl
Sequene Features : Isoforms 3, Variants 455, PTMs 20 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of voltage-gated chloride channel activity
.chloride transmembrane transport
.cellular response to cAMP
  + 20 more...
.PDZ domain binding
.enzyme binding
.chloride channel inhibitor activity
  + 6 more...
.extracellular exosome
.recycling endosome
.protein complex
  + 11 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 455 20
2014-09-19protein level
3 389 20
2014-05-27protein level
3 389 20
2014-02-25protein level
3 386 20
2013-12-09protein level
3 332 20
2013-11-01protein level
3 321 20
2013-09-12protein level
3 321 20
2013-08-17protein level
3 321 20
2013-07-15protein level
3 287 20
2013-06-11protein level
3 287 20
2013-02-12protein level
3 247 48
2012-12-20protein level
3 230 48
2012-10-30protein level
3 251 48
2012-10-07protein level
3 251 22
2012-08-24protein level
3 247 22
2012-07-28protein level
3 249 22
2012-06-08protein level
3 187 22
2012-05-07protein level
3 187 22
2012-04-10protein level
3 187 22
2012-01-13protein level
3 187 22
2011-12-20protein level
3 188 16
2011-11-11protein level
3 188 14
2011-08-23protein level
3 188 14
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P13569-1
0 67 0 168033.9273
NX_P13569-2
1 63 0 161492.5679
NX_P13569-3
0 24 0 69185.2922
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-349854,EBI-349787 SLC9A3R1  
  .positive regulation of intrinsic apoptotic signaling pathway
.renal phosphate ion absorption
.negative regulation of ERK1 and ERK2 cascade
  + 21 more...
.growth factor receptor binding
.protein self-association
.beta-2 adrenergic receptor binding
  + 5 more...
.sperm midpiece
.cell periphery
.extracellular exosome
  + 15 more...
2 EBI-349854,EBI-297852 KRT8  
  .hepatocyte apoptotic process
.extrinsic apoptotic signaling pathway
.cell differentiation involved in embryonic placenta development
  + 5 more...
.scaffold protein binding
.structural molecule activity
.extracellular exosome
.intermediate filament cytoskeleton
.keratin filament
  + 10 more...
3 EBI-349854,EBI-355947 CANX  
  .clathrin-mediated endocytosis
.chaperone-mediated protein folding
.synaptic vesicle endocytosis
  + 9 more...
.poly(A) RNA binding
.carbohydrate binding
.calcium ion binding
.integral component of lumenal side of endoplasmic reticulum membrane
.extracellular exosome
.ER-mitochondrion membrane contact site
  + 13 more...
4 EBI-349854,EBI-77683 BCAP31  
  .positive regulation of intrinsic apoptotic signaling pathway
.protein localization to endoplasmic reticulum exit site
.positive regulation of mitochondrial calcium ion concentration
  + 11 more...
.N/A .integral component of lumenal side of endoplasmic reticulum membrane
.endoplasmic reticulum-Golgi intermediate compartment membrane
.Golgi cisterna membrane
  + 7 more...
5 EBI-349854,EBI-1149760 SLC9A3R2  
  .negative regulation of phosphatidylinositol 3-kinase signaling
.protein complex assembly
.phosphatase binding
.protein C-terminus binding
.beta-catenin binding
.receptor binding
.extracellular exosome
.apical plasma membrane
.endomembrane system
  + 4 more...
6 EBI-349854,EBI-349819 PDZK1  
  .positive regulation of protein targeting to membrane
.establishment of protein localization to plasma membrane
.regulation of anion transport
  + 5 more...
.PDZ domain binding
.transporter activity
.extracellular exosome
.membrane raft
.microvillus membrane
  + 4 more...
7 EBI-349854,EBI-1792052 SLC26A8  
  .chloride transmembrane transport
.sulfate transmembrane transport
.meiotic cell cycle
  + 7 more...
.oxalate transmembrane transporter activity
.anion:anion antiporter activity
.sulfate transmembrane transporter activity
  + 2 more...
.integral component of membrane
.plasma membrane
8 EBI-349854,EBI-348482 RNF5  
  .regulation of autophagic vacuole assembly
.ER-associated misfolded protein catabolic process
.protein K48-linked ubiquitination
  + 5 more...
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.mitochondrial membrane
.integral component of membrane
.endoplasmic reticulum membrane
9 EBI-349854,EBI-398977 DERL1  
  .establishment of protein localization
.protein destabilization
.retrograde protein transport, ER to cytosol
  + 4 more...
.MHC class I protein binding
.receptor activity
.protease binding
.integral component of endoplasmic reticulum membrane
.integral component of membrane
.membrane
  + 4 more...
10 EBI-349854,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
11 EBI-349854,EBI-765995 LPAR2  
  .positive regulation of Rho protein signal transduction
.positive regulation of cytosolic calcium ion concentration
.activation of phospholipase C activity
  + 2 more...
.lysophosphatidic acid receptor activity
.lipid binding
.G-protein coupled receptor activity
.cell surface
.integral component of plasma membrane
.plasma membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder133
intestine232
kidney9
liver38
lung5
muscle9
ovary19
pancreas117
salivary gland49
stomach20
thyroid21
trachea19
uterus17
Health State
TissuesTPM*
normal12
colorectal tumor408
gastrointestinal tumor16
germ cell tumor7
leukemia10
non-neoplasia10
pancreatic tumor47
uterine tumor44
Developmental Stage
TissuesTPM*
adult35
fetus14
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
appendix5.1
colon44
duodenum38.2
gallbladder56.5
liver1.2
lung7.5
pancreas90
prostate1.9
salivary gland20.9
small intestine19.5
stomach3.9
testis3.2
urinary bladder1.7
Tissues
TissuesExpression level
adrenal glandMedium
breastMedium
bronchusLow
cerebellumLow
cerebral cortexMedium
colonLow
duodenumMedium
epididymisLow
fallopian tubeLow
gallbladderHigh
kidneyLow
lateral ventricleLow
liverLow
nasopharynxMedium
oral mucosaLow
pancreasMedium
placentaLow
rectumLow
salivary glandMedium
seminal vesicleMedium
skin 1Low
small intestineLow
soft tissue 1Low
soft tissue 2Low
testisLow
thyroid glandLow
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#219700, phenotype) Cystic fibrosis; CFOMIM
2(#277180, phenotype) Vas deferens, congenital bilateral aplasia of; CBAVDOMIM
3(*602421, gene) Cystic fibrosis transmembrane conductance regulator; CFTROMIM


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