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> Protein (NX_P13612)
Protein (NX_P13612)
Protein
Gene SymbolITGA4 to neXtProt (NX_P13612)
DescriptionIntegrin alpha-4
Chromosome2
Location2q31.3 (182321929 ~ 182400914) to Ensembl
Sequene Features : Isoforms 2, Variants 191, PTMs 36 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of protein homodimerization activity
.T cell migration
.chorio-allantoic fusion
  + 18 more...
.cell adhesion molecule binding
.metal ion binding
.extracellular exosome
.integrin alpha4-beta7 complex
.membrane
  + 5 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 191 36
2014-09-19protein level
1 133 36
2014-05-27protein level
1 133 36
2014-02-25protein level
1 133 36
2013-12-09protein level
1 101 36
2013-11-01protein level
1 97 36
2013-09-12protein level
1 97 36
2013-08-17protein level
1 97 36
2013-07-15protein level
1 60 21
2013-06-11protein level
1 60 21
2013-02-12protein level
1 11 21
2012-12-20protein level
1 12 21
2012-10-30protein level
1 19 21
2012-10-07protein level
1 19 21
2012-08-24protein level
1 19 21
2012-07-28protein level
1 19 21
2012-06-08protein level
1 25 21
2012-05-07protein level
1 19 21
2012-04-10protein level
1 19 21
2012-01-13protein level
1 13 21
2011-12-20protein level
1 13 21
2011-11-11protein level
1 13 21
2011-08-23protein level
1 13 21
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P13612-1
40 6 0 114826.2268
NX_P13612-2
1 6 0 21521.818
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-703044,EBI-1051449 TGFB1I1  
  .positive regulation of transcription, DNA-templated
.negative regulation of fat cell differentiation
.cell fate commitment
  + 12 more...
.I-SMAD binding
.androgen receptor binding
.Roundabout binding
  + 2 more...
.nuclear matrix
.focal adhesion
.cytoskeleton
  + 2 more...
2 EBI-703044,EBI-703066 ITGB1  
  .negative regulation of anoikis
.positive regulation of establishment of protein localization to plasma membrane
.response to transforming growth factor beta
  + 57 more...
.collagen binding involved in cell-matrix adhesion
.cell adhesion molecule binding
.protein heterodimerization activity
  + 5 more...
.synaptic membrane
.invadopodium membrane
.extracellular exosome
  + 32 more...
3 EBI-703044,EBI-702209 PXN  
  .growth hormone receptor signaling pathway
.branching morphogenesis of an epithelial tube
.focal adhesion assembly
  + 16 more...
.vinculin binding
.zinc ion binding
.beta-catenin binding
.lamellipodium
.cell cortex
.focal adhesion
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood57
bone13
bone marrow41
brain5
connective tissue13
ear62
embryonic tissue9
eye9
heart11
intestine17
kidney28
liver34
lung5
lymph45
lymph node77
mammary gland6
mouth30
muscle37
ovary19
pancreas4
pharynx24
placenta14
prostate15
skin28
spleen56
stomach20
testis11
thymus363
trachea19
uterus12
vascular116
Health State
TissuesTPM*
normal21
bladder carcinoma56
breast (mammary gland) tumor10
chondrosarcoma24
germ cell tumor56
glioma27
head and neck tumor14
kidney tumor14
leukemia52
lymphoma41
ovarian tumor13
primitive neuroectodermal tumor of the CNS15
prostate cancer28
skin tumor7
Developmental Stage
TissuesTPM*
adult23
neonate96
fetus19
infant42
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.9
adrenal gland2.8
appendix43.5
bone marrow38.4
cerebral cortex1.1
colon9.9
duodenum11.2
esophagus3.5
gallbladder14.2
heart muscle1.5
kidney3.1
liver3.5
lung15.1
lymph node46.6
ovary2
placenta14
prostate3.5
salivary gland3.4
skin1.2
small intestine13.7
spleen50.6
stomach14.5
testis1.8
thyroid gland3.2
urinary bladder18
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*192975, gene) Integrin, alpha-4; ITGA4OMIM


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