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> Protein (NX_P13647)
Protein (NX_P13647)
Protein
Gene SymbolKRT5 to neXtProt (NX_P13647)
DescriptionKeratin, type II cytoskeletal 5
Chromosome12
Location12q13.13 (52908359 ~ 52914471) to Ensembl
Sequene Features : Isoforms 1, Variants 166, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cell junction assembly
.hemidesmosome assembly
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.keratin filament
.membrane
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 166 12
2014-09-19protein level
1 139 12
2014-05-27protein level
1 139 18
2014-02-25protein level
1 135 18
2013-12-09protein level
1 104 18
2013-11-01protein level
1 97 16
2013-09-12protein level
1 97 16
2013-08-17protein level
1 97 16
2013-07-15protein level
1 81 16
2013-06-11protein level
1 81 16
2013-02-12protein level
1 68 7
2012-12-20protein level
1 69 7
2012-10-30protein level
1 71 7
2012-10-07protein level
1 71 7
2012-08-24protein level
1 65 7
2012-07-28protein level
1 66 7
2012-06-08protein level
1 71 7
2012-05-07protein level
1 71 7
2012-04-10protein level
1 71 7
2012-01-13protein level
1 77 7
2011-12-20protein level
1 77 7
2011-11-11protein level
1 77 6
2011-08-23protein level
1 78 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P13647-1
21 0 7 62339.7986
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-702187,EBI-1047263 KRT38  
  .N/A .structural molecule activity .extracellular exosome
.intermediate filament
2 EBI-702187,EBI-1633210 ALOX12  
  .lipoxin B4 biosynthetic process
.lipoxin A4 biosynthetic process
.lipoxin metabolic process
  + 29 more...
.hepoxilin A3 synthase activity
.hepoxilin-epoxide hydrolase activity
.oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
  + 3 more...
.extracellular exosome
.sarcolemma
.membrane
  + 2 more...
3 EBI-702187,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
4 EBI-702187,EBI-9087684 PKP1  
  .intermediate filament bundle assembly
.single organismal cell-cell adhesion
.programmed cell death
  + 5 more...
.structural constituent of epidermis
.intermediate filament binding
.lamin binding
.signal transducer activity
.extracellular exosome
.intracellular membrane-bounded organelle
.desmosome
  + 4 more...
5 EBI-702187,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
6 EBI-702187,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
7 EBI-702187,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
bladder401
blood16
brain345
cervix185
embryonic tissue9
esophagus6847
eye402
heart279
intestine25
larynx9801
lung256
mammary gland383
mouth6470
muscle75
ovary59
pancreas402
pharynx957
placenta60
prostate379
salivary gland49
skin1665
testis2
thymus1794
thyroid343
trachea1564
umbilical cord2106
uterus224
Health State
TissuesTPM*
normal168
bladder carcinoma682
breast (mammary gland) tumor53
cervical tumor28
colorectal tumor53
esophageal tumor5508
germ cell tumor3
glioma3339
head and neck tumor4214
leukemia21
lung tumor544
non-neoplasia393
ovarian tumor65
pancreatic tumor819
primitive neuroectodermal tumor of the CNS23
prostate cancer269
skin tumor1555
uterine tumor355
Developmental Stage
TissuesTPM*
adult350
neonate933
fetus37
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.3
appendix3.1
bone marrow2
cerebral cortex1
esophagus1761.7
gallbladder1.1
liver2
lung4
lymph node3.6
placenta1
prostate87.9
salivary gland107.7
skin2399.1
spleen1.1
thyroid gland1.2
urinary bladder62.6
Tissues
TissuesExpression level
breastMedium
bronchusHigh
cervix, uterineHigh
epididymisHigh
esophagusHigh
nasopharynxHigh
oral mucosaHigh
prostateHigh
salivary glandMedium
seminal vesicleHigh
skin 1High
skin 2High
tonsilHigh
urinary bladderHigh
vaginaHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#131760, phenotype) Epidermolysis bullosa simplex, dowling-meara typeOMIM
2(#131800, phenotype) Epidermolysis bullosa simplex, localizedOMIM
3(#131900, phenotype) Epidermolysis bullosa simplex, generalizedOMIM
4(#131960, phenotype) Epidermolysis bullosa simplex with mottled pigmentation; EBS-MPOMIM
5(*148040, gene) Keratin 5; KRT5OMIM
6(#179850, phenotype) Dowling-degos disease; DDDOMIM
7(#609352, phenotype) Epidermolysis bullosa simplex with migratory circinate erythemaOMIM


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