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> Protein (NX_P13671)
Protein (NX_P13671)
Protein
Gene SymbolC6 to neXtProt (NX_P13671)
DescriptionComplement component C6
Chromosome5
Location5p13.1 (41142336 ~ 41261540) to Ensembl
Sequene Features : Isoforms 1, Variants 245, PTMs 42 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of angiogenesis
.innate immune response
.regulation of complement activation
  + 5 more...
.N/A .extracellular exosome
.membrane attack complex
.extracellular region
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 245 42
2014-09-19protein level
1 176 42
2014-05-27protein level
1 176 42
2014-02-25protein level
1 176 42
2013-12-09protein level
1 145 42
2013-11-01protein level
1 131 42
2013-09-12protein level
1 131 42
2013-08-17protein level
1 131 42
2013-07-15protein level
1 104 42
2013-06-11protein level
1 104 42
2013-02-12protein level
1 48 43
2012-12-20protein level
1 46 43
2012-10-30protein level
1 54 43
2012-10-07protein level
1 54 43
2012-08-24protein level
1 39 43
2012-07-28protein level
1 39 43
2012-06-08protein level
1 42 35
2012-05-07protein level
1 42 35
2012-04-10protein level
1 42 35
2012-01-13protein level
1 22 35
2011-12-20protein level
1 22 35
2011-11-11protein level
1 22 35
2011-08-23protein level
1 22 35
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P13671-1
46 0 0 104717.7136
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1753221,EBI-389883 NCK1  
  .negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bladder33
connective tissue6
heart11
kidney14
liver204
lung29
pancreas32
testis11
uterus4
Health State
TissuesTPM*
normal21
liver tumor104
pancreatic tumor28
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult17
fetus48
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue24
adrenal gland2.6
colon1.4
duodenum1
gallbladder14.9
heart muscle29
kidney1.6
liver285.2
lung3.9
ovary2.4
pancreas21.2
placenta1.4
salivary gland1.5
small intestine1.7
stomach2.6
testis6.9
Tissues
TissuesExpression level
breastMedium
cerebral cortexLow
endometrium 1Low
endometrium 2Low
fallopian tubeMedium
kidneyMedium
liverLow
lungLow
tonsilLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*217050, gene) Complement component 6; C6OMIM
2(#612446, phenotype) Complement component 6 deficiency; C6DOMIM


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