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> Protein (NX_P13674)
Protein (NX_P13674)
Protein
Gene SymbolP4HA1 to neXtProt (NX_P13674)
DescriptionProlyl 4-hydroxylase subunit alpha-1
Chromosome10
Location10q22.1 (74766975 ~ 74856732) to Ensembl
Sequene Features : Isoforms 3, Variants 60, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.collagen fibril organization
.peptidyl-proline hydroxylation to 4-hydroxy-L-proline
.L-ascorbic acid binding
.oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
.iron ion binding
.procollagen-proline 4-dioxygenase activity
.intracellular membrane-bounded organelle
.procollagen-proline 4-dioxygenase complex
.membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 60 5
2014-09-19protein level
3 42 5
2014-05-27protein level
3 42 5
2014-02-25protein level
3 41 5
2013-12-09protein level
3 25 5
2013-11-01protein level
3 23 4
2013-09-12protein level
3 23 4
2013-08-17protein level
3 23 4
2013-07-15protein level
3 16 2
2013-06-11protein level
3 16 2
2013-02-12protein level
3 5 6
2012-12-20protein level
3 7 6
2012-10-30protein level
2 9 4
2012-10-07protein level
2 9 2
2012-08-24protein level
2 8 2
2012-07-28protein level
2 8 2
2012-06-08protein level
2 12 2
2012-05-07protein level
2 12 2
2012-04-10protein level
2 12 2
2012-01-13protein level
2 13 2
2011-12-20protein level
2 13 2
2011-11-11protein level
2 13 2
2011-08-23protein level
2 13 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P13674-1
1 22 0 61010.8547
NX_P13674-2
0 23 0 60928.7656
NX_P13674-3
1 22 0 58920.8482
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1237386,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
blood8
bone55
bone marrow102
brain1
cervix20
connective tissue87
ear124
embryonic tissue4
esophagus99
eye4
heart11
intestine21
kidney14
larynx127
liver4
lung8
lymph22
lymph node11
mammary gland13
mouth15
muscle84
nerve64
ovary19
pancreas28
pharynx270
placenta35
prostate42
skin23
stomach52
testis29
thymus37
trachea77
uterus30
vascular135
Health State
TissuesTPM*
normal51
adrenal tumor79
cervical tumor28
chondrosarcoma84
colorectal tumor26
esophageal tumor57
gastrointestinal tumor8
germ cell tumor3
glioma46
head and neck tumor29
kidney tumor43
leukemia42
liver tumor62
lung tumor68
lymphoma13
non-neoplasia51
ovarian tumor26
pancreatic tumor38
primitive neuroectodermal tumor of the CNS15
prostate cancer57
skin tumor7
uterine tumor55
Developmental Stage
TissuesTPM*
adult6
embryoid body171
blastocyst48
neonate96
fetus17
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue17.9
adrenal gland26.4
appendix21.4
bone marrow9.1
cerebral cortex12.3
colon16.6
duodenum10.3
esophagus10.5
gallbladder29.5
heart muscle27.3
kidney28.2
liver64.6
lung23.5
lymph node16.1
ovary30.9
pancreas7.1
placenta58.7
prostate21.2
salivary gland6.2
skin13.6
small intestine13.8
spleen17.5
stomach19.3
testis19.8
thyroid gland14
urinary bladder28.7
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineHigh
colonMedium
duodenumHigh
endometrium 1High
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
heart muscleLow
hippocampusHigh
kidneyMedium
lateral ventricleMedium
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaHigh
ovaryMedium
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skeletal muscleLow
skin 1Medium
skin 2High
small intestineHigh
smooth muscleLow
soft tissue 1Medium
soft tissue 2Medium
spleenHigh
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderMedium
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*176710, gene) Procollagen-proline, 2-oxoglutarate-4-dioxygenase, alpha subunit,OMIM


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