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> Protein (NX_P13693)
Protein (NX_P13693)
Protein
Gene SymbolTPT1 to neXtProt (NX_P13693)
DescriptionTranslationally-controlled tumor protein
Chromosome13
Location13q14.13 (45911008 ~ 45915505) to Ensembl
Sequene Features : Isoforms 2, Variants 20, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
.negative regulation of apoptotic process
.regulation of apoptotic process
  + 3 more...
.poly(A) RNA binding
.calcium ion binding
.extracellular exosome
.multivesicular body
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 20 6
2014-09-19protein level
2 11 6
2014-05-27protein level
2 11 7
2014-02-25protein level
1 11 7
2013-12-09protein level
1 8 7
2013-11-01protein level
1 7 4
2013-09-12protein level
1 7 4
2013-08-17protein level
1 7 4
2013-07-15protein level
1 5 3
2013-06-11protein level
1 5 3
2013-02-12protein level
1 1 4
2012-12-20protein level
1 1 4
2012-10-30protein level
1 1 4
2012-10-07protein level
1 1 4
2012-08-24protein level
1 1 4
2012-07-28protein level
1 1 4
2012-06-08protein level
1 3 4
2012-05-07protein level
1 16 4
2012-04-10protein level
1 16 4
2012-01-13protein level
1 16 4
2011-12-20protein level
1 16 4
2011-11-11protein level
1 16 4
2011-08-23protein level
1 16 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P13693-1
2 4 1 19582.5262
NX_P13693-2
0 4 1 15586.5537
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1783169,EBI-366083 TP53  
  .positive regulation of intrinsic apoptotic signaling pathway
.positive regulation of reactive oxygen species metabolic process
.negative regulation of reactive oxygen species metabolic process
  + 99 more...
.protein phosphatase 2A binding
.chaperone binding
.protein N-terminus binding
  + 27 more...
.protein complex
.PML body
.nuclear matrix
  + 11 more...
2 EBI-1783169,EBI-352682 HSPB1  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.platelet aggregation
  + 17 more...
.poly(A) RNA binding
.ubiquitin binding
.identical protein binding
  + 3 more...
.extracellular exosome
.Z disc
.focal adhesion
  + 8 more...
3 EBI-1783169,EBI-358778 ATP1A1  
  .potassium ion import across plasma membrane
.response to glycoside
.cell communication by electrical coupling involved in cardiac conduction
  + 22 more...
.steroid hormone binding
.chaperone binding
.ADP binding
  + 5 more...
.extracellular exosome
.protein complex
.melanosome
  + 13 more...
4 EBI-1783169,EBI-358607 EEF1D  
  .cellular response to ionizing radiation
.cellular protein metabolic process
.positive regulation of I-kappaB kinase/NF-kappaB signaling
  + 8 more...
.activating transcription factor binding
.heat shock protein binding
.translation factor activity, RNA binding
  + 3 more...
.eukaryotic translation elongation factor 1 complex
.cytosol
.cytoplasm
  + 2 more...
5 EBI-1783169,EBI-358993 TRIP13  
  .regulation of nucleic acid-templated transcription
.oogenesis
.spermatid development
  + 8 more...
.identical protein binding
.ATP binding
.transcription cofactor activity
.nucleus
.male germ cell nucleus
6 EBI-1783169,EBI-712609 TSC22D1  
  .negative regulation of apoptotic process
.positive regulation of apoptotic process
.positive regulation of cell proliferation
.transcription from RNA polymerase II promoter
.sequence-specific DNA binding transcription factor activity .cytoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue2798
adrenal gland941
ascites1104
bladder904
blood2110
bone1284
bone marrow1477
brain662
cervix948
connective tissue603
ear3664
embryonic tissue1056
esophagus744
eye1029
heart1798
intestine2026
kidney863
larynx1193
liver1013
lung994
lymph948
lymph node857
mammary gland1229
mouth1194
muscle4004
nerve1029
ovary1054
pancreas3265
parathyroid1505
pharynx4812
pituitary gland1331
placenta724
prostate3086
salivary gland1431
skin640
spleen1292
stomach2748
testis772
thymus1066
thyroid2940
tonsil2291
trachea308
umbilical cord4577
uterus1408
vascular2265
Health State
TissuesTPM*
adrenal tumor948
bladder carcinoma1478
breast (mammary gland) tumor1299
cervical tumor1246
chondrosarcoma845
colorectal tumor2915
esophageal tumor811
gastrointestinal tumor1898
germ cell tumor771
glioma503
head and neck tumor2764
kidney tumor1771
leukemia1958
liver tumor1426
lung tumor1732
lymphoma1080
non-neoplasia507
ovarian tumor1036
pancreatic tumor971
primitive neuroectodermal tumor of the CNS314
prostate cancer4612
retinoblastoma1248
skin tumor670
soft tissue/muscle tissue tumor1213
uterine tumor1975
Developmental Stage
TissuesTPM*
embryoid body1514
blastocyst439
neonate2124
fetus768
infant510
juvenile755
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1200.7
adrenal gland1639.2
appendix1361.7
bone marrow1621.6
cerebral cortex495.9
colon1398.6
duodenum1617.4
esophagus1529.8
gallbladder1505.7
heart muscle1444.8
kidney1418.2
liver1443.5
lung1175.9
lymph node1816.6
ovary1964.6
pancreas2183.8
placenta1519.5
prostate1252.6
salivary gland2535.5
skin1188.9
small intestine1563.4
spleen1277.8
stomach1361.5
testis466.5
thyroid gland1571
urinary bladder1897.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600763, gene) Tumor protein, translationally-controlled 1; TPT1OMIM


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