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> Protein (NX_P13805)
Protein (NX_P13805)
Protein
Gene SymbolTNNT1 to neXtProt (NX_P13805)
DescriptionTroponin T, slow skeletal muscle
Chromosome19
Location19q13.42 (55644162 ~ 55660722) to Ensembl
Sequene Features : Isoforms 3, Variants 50, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of muscle contraction
.slow-twitch skeletal muscle fiber contraction
.muscle filament sliding
.skeletal muscle contraction
.tropomyosin binding .troponin complex
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 50 1
2014-09-19protein level
3 31 1
2014-05-27protein level
3 31 1
2014-02-25protein level
3 31 1
2013-12-09protein level
3 20 1
2013-11-01protein level
3 20 1
2013-09-12protein level
3 20 1
2013-08-17protein level
3 20 1
2013-07-15protein level
3 13 1
2013-06-11protein level
3 13 1
2013-02-12protein level
3 4 9
2012-12-20protein level
3 4 7
2012-10-30protein level
3 3 9
2012-10-07protein level
3 3 3
2012-08-24protein level
3 2 3
2012-07-28protein level
3 2 3
2012-06-08protein level
3 3 3
2012-05-07protein level
3 3 3
2012-04-10protein level
3 3 3
2012-01-13protein level
3 8 3
2011-12-20protein level
3 8 3
2011-11-11protein level
3 8 3
2011-08-23protein level
3 8 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P13805-1
1 6 2 32927.8102
NX_P13805-2
1 5 2 30077.4422
NX_P13805-3
0 6 2 31222.9633
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-726527,EBI-740738 LDOC1  
  .negative regulation of cell proliferation .N/A .nucleolus
.nucleus
2 EBI-726527,EBI-351158 TPM1  
  .cardiac muscle contraction
.ventricular cardiac muscle tissue morphogenesis
.positive regulation of stress fiber assembly
  + 15 more...
.structural constituent of muscle
.cytoskeletal protein binding
.structural constituent of cytoskeleton
.actin binding
.ruffle membrane
.bleb
.filamentous actin
  + 5 more...
3 EBI-726527,EBI-716225 TBPL1  
  .spermatid nucleus differentiation
.transcription from RNA polymerase II promoter
.regulation of transcription, DNA-templated
  + 3 more...
.transcription coactivator activity
.DNA binding
.cytoplasm
.transcription factor TFIIA complex
4 EBI-726527,EBI-2007911 NFE2L2  
  .positive regulation of reactive oxygen species metabolic process
.negative regulation of endothelial cell apoptotic process
.regulation of removal of superoxide radicals
  + 19 more...
.transcription regulatory region DNA binding
.protein domain specific binding
.sequence-specific DNA binding transcription factor activity
  + 5 more...
.protein-DNA complex
.plasma membrane
.cytosol
  + 5 more...
5 EBI-726527,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
6 EBI-726527,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
7 EBI-726527,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
8 EBI-726527,EBI-399246 MORF4L1  
  .histone H2A acetylation
.histone H4 acetylation
.regulation of growth
  + 6 more...
.protein N-terminus binding
.chromatin binding
.NuA4 histone acetyltransferase complex
.Sin3 complex
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
bone13
brain2
cervix41
connective tissue6
embryonic tissue46
eye57
heart301
intestine12
kidney14
liver34
lung26
mammary gland99
mouth393
muscle5161
nerve64
ovary137
pancreas32
placenta7
prostate36
skin80
testis6
uterus99
Health State
TissuesTPM*
normal169
breast (mammary gland) tumor161
chondrosarcoma12
colorectal tumor17
gastrointestinal tumor8
germ cell tumor18
glioma27
head and neck tumor141
kidney tumor43
liver tumor31
lung tumor68
ovarian tumor170
pancreatic tumor66
prostate cancer19
retinoblastoma172
skin tumor119
soft tissue/muscle tissue tumor151
uterine tumor88
Developmental Stage
TissuesTPM*
adult251
embryoid body28
blastocyst97
fetus25
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue1
bone marrow1.4
cerebral cortex6.9
esophagus396.8
heart muscle120.1
kidney2.7
lung4.3
placenta6.2
prostate240.4
skin37.1
testis8.4
Tissues
TissuesExpression level
heart muscleLow
skeletal muscleHigh
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*191041, gene) Troponin t1, skeletal, slow; TNNT1OMIM
2(#605355, phenotype) Nemaline myopathy 5; NEM5OMIM


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