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> Protein (NX_P14136)
Protein (NX_P14136)
Protein
Gene SymbolGFAP to neXtProt (NX_P14136)
DescriptionGlial fibrillary acidic protein
Chromosome17
Location17q21.31 (42982376 ~ 42994305) to Ensembl
Sequene Features : Isoforms 3, Variants 146, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.long-term synaptic potentiation
.Bergmann glial cell differentiation
.regulation of neurotransmitter uptake
  + 7 more...
.structural constituent of cytoskeleton .astrocyte end-foot
.cell body
.membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 146 10
2014-09-19protein level
3 86 10
2014-05-27protein level
3 86 11
2014-02-25protein level
3 87 11
2013-12-09protein level
3 61 11
2013-11-01protein level
3 59 11
2013-09-12protein level
3 59 6
2013-08-17protein level
3 59 6
2013-07-15protein level
3 49 6
2013-06-11protein level
3 49 6
2013-02-12protein level
3 38 18
2012-12-20protein level
3 38 18
2012-10-30protein level
3 40 18
2012-10-07protein level
3 40 6
2012-08-24protein level
3 35 6
2012-07-28protein level
3 35 6
2012-06-08protein level
3 29 6
2012-05-07protein level
3 29 6
2012-04-10protein level
3 29 6
2012-01-13protein level
3 29 6
2011-12-20protein level
3 46 6
2011-11-11protein level
3 46 6
2011-08-23protein level
3 46 3
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P14136-1
1 22 2 49849.5
NX_P14136-2
3 22 2 50257.6152
NX_P14136-3
1 22 2 49477.4721
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-744302,EBI-348555 PIAS2  
  .negative regulation of androgen receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 7 more...
.SUMO ligase activity
.androgen receptor binding
.ligase activity
  + 4 more...
.nuclear speck
.PML body
.nucleoplasm
.nucleus
2 EBI-744302,EBI-1757866 MOS  
  .negative regulation of metaphase/anaphase transition of meiotic cell cycle
.establishment of meiotic spindle orientation
.protein autophosphorylation
  + 6 more...
.ATP binding
.MAP kinase kinase kinase activity
.protein serine/threonine kinase activity
.cytoplasm
3 EBI-744302,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
4 EBI-744302,EBI-739566 KRT15  
  .activation of mitophagy in response to mitochondrial depolarization
.epidermis development
.scaffold protein binding
.structural constituent of cytoskeleton
.extracellular exosome
.intermediate filament
.nucleus
5 EBI-744302,EBI-739696 LMO2  
  .cellular response to thyroid hormone stimulus
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of erythrocyte differentiation
  + 3 more...
.E-box binding
.cofactor binding
.bHLH transcription factor binding
  + 7 more...
.transcription factor complex
.nucleus
6 EBI-744302,EBI-748689 RORA  
  .regulation of cholesterol homeostasis
.T-helper 17 cell differentiation
.cellular response to hypoxia
  + 27 more...
.direct ligand regulated sequence-specific DNA binding transcription factor activity
.sequence-specific DNA binding
.zinc ion binding
  + 10 more...
.nucleoplasm
.nucleus
7 EBI-744302,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
8 EBI-744302,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
9 EBI-744302,EBI-514538 BIRC2  
  .regulation of reactive oxygen species metabolic process
.regulation of cysteine-type endopeptidase activity
.inhibition of cysteine-type endopeptidase activity involved in apoptotic process
  + 40 more...
.protein N-terminus binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.ligase activity
  + 3 more...
.membrane raft
.CD40 receptor complex
.cytoplasmic side of plasma membrane
  + 4 more...
10 EBI-744302,EBI-740767 ZC2HC1C  
  .N/A .metal ion binding .N/A
11 EBI-744302,EBI-749051 C6orf165  
  .N/A .N/A .N/A
12 EBI-744302,EBI-10274069 LGALS14  
  .positive regulation of T cell apoptotic process
.apoptotic process
.carbohydrate binding .nucleus
13 EBI-744302,EBI-10232538 PIH1D2  
  .N/A .Ral GTPase binding .N/A
14 EBI-744302,EBI-722667 SH3YL1  
  .regulation of ruffle assembly
.phosphatidylinositol biosynthetic process
.phosphatidylinositol binding
.phosphatase binding
.ruffle membrane
15 EBI-744302,EBI-398874 NXF1  
  .poly(A)+ mRNA export from nucleus
.viral process
.gene expression
.mRNA export from nucleus
.poly(A) RNA binding
.nucleocytoplasmic transporter activity
.mRNA binding
.nucleotide binding
.nuclear inclusion body
.nuclear speck
.cytosol
  + 2 more...
16 EBI-744302,EBI-742802 FAM50B  
  .N/A .N/A .nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland91
blood155
bone marrow102
connective tissue6
eye38
intestine68
kidney294
larynx1406
liver9
mammary gland13
muscle28
nerve2252
pituitary gland121
placenta10
testis4
Health State
TissuesTPM*
normal625
breast (mammary gland) tumor21
colorectal tumor142
germ cell tumor41
glioma4916
head and neck tumor246
kidney tumor856
leukemia201
non-neoplasia672
Developmental Stage
TissuesTPM*
adult424
fetus118
infant510
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue2.5
appendix1.9
cerebral cortex1372.3
heart muscle3
kidney1.4
testis1.1
Tissues
TissuesExpression level
cerebellumMedium
cerebral cortexMedium
hippocampusMedium
lateral ventricleMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*137780, gene) Glial fibrillary acidic protein; GFAPOMIM
2(#203450, phenotype) Alexander diseaseOMIM


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