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> Protein (NX_P14222)
Protein (NX_P14222)
Protein
Gene SymbolPRF1 to neXtProt (NX_P14222)
DescriptionPerforin-1
Chromosome10
Location10q22.1 (72357104 ~ 72362531) to Ensembl
Sequene Features : Isoforms 1, Variants 104, PTMs 11 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.defense response to virus
.protein homooligomerization
.cytolysis
  + 5 more...
.wide pore channel activity
.calcium ion binding
.cytolytic granule
.endosome lumen
.cytoplasmic membrane-bounded vesicle
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 104 11
2014-09-19protein level
1 85 11
2014-05-27protein level
1 85 11
2014-02-25protein level
1 85 11
2013-12-09protein level
1 55 11
2013-11-01protein level
1 52 11
2013-09-12protein level
1 52 11
2013-08-17protein level
1 52 11
2013-07-15protein level
1 41 11
2013-06-11protein level
1 41 11
2013-02-12protein level
1 26 11
2012-12-20protein level
1 26 11
2012-10-30protein level
1 26 11
2012-10-07protein level
1 26 11
2012-08-24protein level
1 24 11
2012-07-28protein level
1 24 11
2012-06-08protein level
1 26 11
2012-05-07protein level
1 26 11
2012-04-10protein level
1 26 11
2012-01-13protein level
1 19 11
2011-12-20protein level
1 19 11
2011-11-11protein level
1 19 11
2011-08-23protein level
1 19 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P14222-1
27 0 0 61338.5592
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-724466,EBI-2505785 GZMB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.natural killer cell mediated cytotoxicity
  + 7 more...
.serine-type peptidase activity
.serine-type endopeptidase activity
.intracellular membrane-bounded organelle
.membrane
.cytosol
  + 3 more...
2 EBI-724466,EBI-948001 KRT31  
  .epidermis development .structural constituent of cytoskeleton .extracellular exosome
.intermediate filament
.extracellular space
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder33
blood220
bone marrow20
brain5
connective tissue6
eye4
intestine8
kidney9
liver24
lung26
lymph node22
mammary gland13
muscle9
placenta10
prostate5
spleen1835
stomach10
testis2
thymus50
trachea38
uterus4
Health State
TissuesTPM*
normal46
breast (mammary gland) tumor21
gastrointestinal tumor8
germ cell tumor7
glioma9
leukemia31
liver tumor41
non-neoplasia20
soft tissue/muscle tissue tumor7
Developmental Stage
TissuesTPM*
adult10
neonate32
fetus1
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4
adrenal gland1.7
appendix7.4
bone marrow17
colon2.3
duodenum1.8
esophagus1.8
gallbladder4.4
heart muscle1.1
liver2.9
lung15.3
lymph node18.7
placenta2.6
salivary gland1.6
small intestine4.1
spleen37.2
stomach4.5
testis1
thyroid gland1
urinary bladder5.3
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*170280, gene) Perforin 1; PRF1OMIM
2(#603553, phenotype) Hemophagocytic lymphohistiocytosis, familial, 2; FHL2OMIM
3various leukaemia;lymphoma;Type 2 familial hemophagocytic lymphohistiocytosisCGP


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