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> Protein (NX_P14373)
Protein (NX_P14373)
Protein
Gene SymbolTRIM27 to neXtProt (NX_P14373)
DescriptionZinc finger protein RFP
Chromosome6
Location6p22.1 (28870779 ~ 28891766) to Ensembl
Sequene Features : Isoforms 2, Variants 40, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 40 8
2014-09-19protein level
2 27 8
2014-05-27protein level
2 27 8
2014-02-25protein level
2 11 8
2013-12-09protein level
2 5 8
2013-11-01protein level
2 5 8
2013-09-12protein level
2 5 8
2013-08-17protein level
2 5 8
2013-07-15protein level
2 5 1
2013-06-11protein level
2 5 1
2013-02-12protein level
2 5 1
2012-12-20protein level
2 5 1
2012-10-30protein level
2 6 1
2012-10-07protein level
2 6 1
2012-08-24protein level
2 6 1
2012-07-28protein level
2 6 1
2012-06-08protein level
2 9 1
2012-05-07protein level
2 9 1
2012-04-10protein level
2 9 1
2012-01-13protein level
2 5 1
2011-12-20protein level
2 5 1
2011-11-11protein level
2 5 0
2011-08-23protein level
2 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P14373-1
7 15 1 58451.5972
NX_P14373-2
0 15 0 41412.4597
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-719493,EBI-618295 STK25  
  .Golgi reassembly
.establishment of Golgi localization
.Golgi localization
  + 12 more...
.metal ion binding
.protein homodimerization activity
.ATP binding
  + 2 more...
.extracellular exosome
.Golgi apparatus
.cytoplasm
2 EBI-719493,EBI-727004 SDCBP  
  .positive regulation of extracellular exosome assembly
.positive regulation of exosomal secretion
.ephrin receptor signaling pathway
  + 9 more...
.protein N-terminus binding
.protein heterodimerization activity
.syndecan binding
  + 4 more...
.blood microparticle
.extracellular exosome
.melanosome
  + 12 more...
3 EBI-719493,EBI-641107 PIK3C2B  
  .cell chemotaxis
.phosphatidylinositol phosphorylation
.innate immune response
  + 10 more...
.phosphatidylinositol binding
.1-phosphatidylinositol-4-phosphate 3-kinase activity
.1-phosphatidylinositol-3-kinase activity
  + 2 more...
.endocytic vesicle
.phosphatidylinositol 3-kinase complex
.plasma membrane
  + 4 more...
4 EBI-719493,EBI-707554 TXNDC9  
  .cell redox homeostasis .N/A .midbody
.centrosome
.cytoplasm
.nucleus
5 EBI-719493,EBI-1055079 POLR1C  
  .negative regulation of gene expression, epigenetic
.innate immune response
.regulation of gene expression, epigenetic
  + 9 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
.nucleoplasm
6 EBI-719493,EBI-353818 EIF3D  
  .cellular protein metabolic process
.gene expression
.regulation of translational initiation
  + 4 more...
.poly(A) RNA binding
.translation initiation factor activity
.eukaryotic translation initiation factor 3 complex, eIF3m
.eukaryotic 48S preinitiation complex
.eukaryotic 43S preinitiation complex
  + 3 more...
7 EBI-719493,EBI-8646694 DCX  
  .dendrite morphogenesis
.axon extension
.protein autophosphorylation
  + 8 more...
.protein kinase binding
.calcium-dependent protein serine/threonine kinase activity
.microtubule binding
  + 2 more...
.neuron projection
.microtubule associated complex
.microtubule
  + 4 more...
8 EBI-719493,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
9 EBI-719493,EBI-355720 NUDT21  
  .protein tetramerization
.mRNA 3'-end processing
.gene expression
  + 6 more...
.poly(A) RNA binding
.histone deacetylase binding
.protein homodimerization activity
  + 3 more...
.paraspeckles
.mRNA cleavage factor complex
.centrosome
  + 2 more...
10 EBI-719493,EBI-947402 MAPKBP1  
  .N/A .N/A .N/A
11 EBI-719493,EBI-368321 PPL  
  .keratinization .structural constituent of cytoskeleton .extracellular exosome
.desmosome
.plasma membrane
  + 3 more...
12 EBI-719493,EBI-741237 SORBS3  
  .positive regulation of stress fiber assembly
.positive regulation of cytoskeleton organization
.positive regulation of MAPK cascade
  + 5 more...
.vinculin binding
.structural constituent of cytoskeleton
.focal adhesion
.cytoskeleton
.cytosol
.nucleus
13 EBI-719493,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
14 EBI-719493,EBI-743272 USP2  
  .regulation of proteasomal protein catabolic process
.protein stabilization
.positive regulation of skeletal muscle tissue development
  + 11 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin binding
  + 2 more...
.perinuclear region of cytoplasm
.cell cortex
.centrosome
  + 2 more...
15 EBI-719493,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
16 EBI-719493,EBI-2880203 NEBL  
  .cardiac muscle thin filament assembly .actin filament binding
.filamin binding
.structural constituent of muscle
  + 2 more...
.extracellular exosome
.I band
.Z disc
.stress fiber
17 EBI-719493,EBI-2513774 FARS2  
  .gene expression
.tRNA processing
.phenylalanyl-tRNA aminoacylation
.tRNA aminoacylation for protein translation
.ATP binding
.phenylalanine-tRNA ligase activity
.magnesium ion binding
.tRNA binding
.mitochondrial matrix
.mitochondrion
18 EBI-719493,EBI-751540 GPANK1  
  .N/A .nucleic acid binding .N/A
19 EBI-719493,EBI-1757866 MOS  
  .negative regulation of metaphase/anaphase transition of meiotic cell cycle
.establishment of meiotic spindle orientation
.protein autophosphorylation
  + 6 more...
.ATP binding
.MAP kinase kinase kinase activity
.protein serine/threonine kinase activity
.cytoplasm
20 EBI-719493,EBI-3932815 OAS1  
  .regulation of ribonuclease activity
.type I interferon signaling pathway
.interferon-gamma-mediated signaling pathway
  + 9 more...
.metal ion binding
.zinc ion binding
.ATP binding
  + 2 more...
.cytosol
.endoplasmic reticulum
.mitochondrion
  + 3 more...
21 EBI-719493,EBI-73440 EIF4E  
  .positive regulation of mitotic cell cycle
.cellular protein metabolic process
.lung development
  + 11 more...
.poly(A) RNA binding
.translation initiation factor activity
.RNA cap binding
.extracellular exosome
.chromatoid body
.RISC complex
  + 6 more...
22 EBI-719493,EBI-1053651 SNRPB2  
  .gene expression
.RNA splicing
.mRNA processing
  + 2 more...
.snRNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.nucleolus
.U2 snRNP
  + 2 more...
23 EBI-719493,EBI-607085 SNRPA  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.snRNA binding
.RNA binding
.nucleotide binding
.cytoplasm
.nucleolus
.U1 snRNP
  + 2 more...
24 EBI-719493,EBI-744302 GFAP  
  .long-term synaptic potentiation
.Bergmann glial cell differentiation
.regulation of neurotransmitter uptake
  + 7 more...
.structural constituent of cytoskeleton .astrocyte end-foot
.cell body
.membrane
  + 3 more...
25 EBI-719493,EBI-10177272 ZNF250  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
26 EBI-719493,EBI-348444 NELFE  
  .negative regulation of mRNA polyadenylation
.positive regulation of viral transcription
.negative regulation of transcription elongation from RNA polymerase II promoter
  + 4 more...
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.NELF complex
.mitochondrion
.nucleoplasm
.nucleus
27 EBI-719493,EBI-372273 PSMB1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex
.cytosol
  + 4 more...
28 EBI-719493,EBI-295222 XPA  
  .multicellular organism growth
.nucleotide-excision repair, DNA incision
.response to toxic substance
  + 6 more...
.metal ion binding
.protein homodimerization activity
.protein domain specific binding
.damaged DNA binding
.intercellular bridge
.Golgi apparatus
.cytoplasm
  + 2 more...
29 EBI-719493,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
30 EBI-719493,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
31 EBI-719493,EBI-351257 DDX6  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.cytoplasmic mRNA processing body assembly
.viral RNA genome packaging
  + 4 more...
.poly(A) RNA binding
.protein domain specific binding
.ATP binding
  + 3 more...
.intracellular membrane-bounded organelle
.RISC complex
.membrane
  + 5 more...
32 EBI-719493,EBI-355924 MCM7  
  .cellular response to epidermal growth factor stimulus
.response to drug
.regulation of phosphorylation
  + 8 more...
.ATP binding
.single-stranded DNA binding
.DNA helicase activity
.MCM complex
.membrane
.cytosol
  + 3 more...
33 EBI-719493,EBI-603340 PSMB3  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.actin cytoskeleton
.proteasome core complex
  + 7 more...
34 EBI-719493,EBI-750020 CLK2  
  .protein autophosphorylation
.negative regulation of gluconeogenesis
.regulation of RNA splicing
  + 3 more...
.ATP binding
.protein tyrosine kinase activity
.protein serine/threonine/tyrosine kinase activity
.protein serine/threonine kinase activity
.nuclear speck
.nucleoplasm
.nucleus
35 EBI-719493,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
36 EBI-719493,EBI-713847 POLE2  
  .error-prone translesion synthesis
.telomere maintenance via semi-conservative replication
.nucleotide-excision repair, DNA gap filling
  + 10 more...
.DNA-directed DNA polymerase activity
.DNA binding
.intracellular membrane-bounded organelle
.epsilon DNA polymerase complex
.nucleoplasm
37 EBI-719493,EBI-347740 EIF3E  
  .negative regulation of translational initiation
.cellular protein metabolic process
.gene expression
  + 5 more...
.protein N-terminus binding
.poly(A) RNA binding
.translation initiation factor activity
.extracellular exosome
.eukaryotic 48S preinitiation complex
.PML body
  + 7 more...
38 EBI-719493,EBI-456371 CKS1B  
  .cell division
.cell proliferation
.mitotic cell cycle
  + 2 more...
.cyclin-dependent protein serine/threonine kinase regulator activity .nucleoplasm
39 EBI-719493,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
40 EBI-719493,EBI-10223946 WT1-AS  
  .N/A .N/A .N/A
41 EBI-719493,EBI-746238 CDK18  
  .N/A .ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.N/A
42 EBI-719493,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
43 EBI-719493,EBI-2339219 EHHADH  
  .fatty acid beta-oxidation
.internal protein amino acid acetylation
.coenzyme binding
.enzyme binding
.receptor binding
  + 3 more...
.cytosol
.peroxisome
.mitochondrion
44 EBI-719493,EBI-602199 ARHGEF5  
  .positive regulation of podosome assembly
.regulation of GTPase activity
.intracellular signal transduction
  + 2 more...
.GTP binding
.Rho guanyl-nucleotide exchange factor activity
.N/A
45 EBI-719493,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
46 EBI-719493,EBI-747644 ILK  
  .negative regulation of neural precursor cell proliferation
.positive regulation of canonical Wnt signaling pathway
.platelet aggregation
  + 37 more...
.protein kinase binding
.ATP binding
.signal transducer activity
.protein serine/threonine kinase activity
.protein complex
.dendritic shaft
.terminal bouton
  + 13 more...
47 EBI-719493,EBI-358049 BYSL  
  .cell proliferation
.female pregnancy
.cell adhesion
  + 2 more...
.poly(A) RNA binding .apical part of cell
.intracellular membrane-bounded organelle
.membrane
  + 3 more...
48 EBI-719493,EBI-2108053 NEDD9  
  .cell division
.actin filament bundle assembly
.regulation of growth
  + 5 more...
.N/A .lamellipodium
.cell cortex
.focal adhesion
  + 5 more...
49 EBI-719493,EBI-742828 LASP1  
  .positive regulation of signal transduction
.ion transport
.ion transmembrane transporter activity
.zinc ion binding
.SH3/SH2 adaptor activity
.extracellular exosome
.cortical actin cytoskeleton
.focal adhesion
50 EBI-719493,EBI-2510602 JOSD1  
  .N/A .omega peptidase activity .membrane
.plasma membrane
.cytoplasm
51 EBI-719493,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
52 EBI-719493,EBI-10236940 INPP5J  
  .phosphatidylinositol dephosphorylation
.small molecule metabolic process
.inositol phosphate metabolic process
  + 5 more...
.inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity
.inositol-1,4,5-trisphosphate 5-phosphatase activity
.phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity
.inositol-polyphosphate 5-phosphatase activity
.dendritic shaft
.growth cone
.plasma membrane
  + 3 more...
53 EBI-719493,EBI-10237274 ZNF79  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
54 EBI-719493,EBI-2959737 CSRP2  
  .cell differentiation
.multicellular organismal development
.zinc ion binding .focal adhesion
.nucleus
55 EBI-719493,EBI-2866142 FAM214A  
  .N/A .N/A .N/A
56 EBI-719493,EBI-10241197 TSGA10IP  
  .N/A .N/A .N/A
57 EBI-719493,EBI-10241513 PLEKHN1  
  .N/A .N/A .plasma membrane
58 EBI-719493,EBI-740767 ZC2HC1C  
  .N/A .metal ion binding .N/A
59 EBI-719493,EBI-719994 CCDC92  
  .N/A .N/A .centriole
60 EBI-719493,EBI-10244342 MIA3  
  .wound healing
.positive regulation of bone mineralization
.negative regulation of cell migration
  + 6 more...
.N/A .intracellular membrane-bounded organelle
.integral component of membrane
.membrane
.endoplasmic reticulum membrane
61 EBI-719493,EBI-10248548 RNF213  
  .protein autoubiquitination
.protein ubiquitination
.ATPase activity
.ligase activity
.zinc ion binding
.ubiquitin-protein transferase activity
.membrane
.cytoplasm
.nucleolus
62 EBI-719493,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
63 EBI-719493,EBI-7844656 TTLL10  
  .cellular protein modification process .N/A .N/A
64 EBI-719493,EBI-4397613 KCTD9  
  .protein homooligomerization .N/A .N/A
65 EBI-719493,EBI-745689 FAM214B  
  .N/A .N/A .nucleus
66 EBI-719493,EBI-10257016 ZNF572  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
67 EBI-719493,EBI-945833 NOTCH2NL  
  .cell differentiation
.multicellular organismal development
.Notch signaling pathway
.calcium ion binding .cytoplasm
.extracellular region
68 EBI-719493,EBI-10258086 ARPIN  
  .negative regulation of lamellipodium morphogenesis
.negative regulation of actin nucleation
.directional locomotion
.negative regulation of cell migration
.N/A .lamellipodium
69 EBI-719493,EBI-780319 RBM23  
  .mRNA processing .RNA binding
.nucleotide binding
.membrane
.nucleus
70 EBI-719493,EBI-1384254 FAM83A  
  .N/A .N/A .N/A
71 EBI-719493,EBI-10260504 CDC20B  
  .N/A .N/A .N/A
72 EBI-719493,EBI-747107 SIAH1  
  .positive regulation of intrinsic apoptotic signaling pathway
.neuron apoptotic process
.proteasome-mediated ubiquitin-dependent protein catabolic process
  + 11 more...
.ubiquitin protein ligase activity
.identical protein binding
.ligase activity
  + 3 more...
.beta-catenin destruction complex
.plasma membrane
.cytosol
  + 3 more...
73 EBI-719493,EBI-748515 GLYCTK  
  .protein phosphorylation .glycerate kinase activity
.ATP binding
.mitochondrion
.cytoplasm
74 EBI-719493,EBI-3919850 CDKL3  
  .dendrite extension
.positive regulation of dendrite morphogenesis
.negative regulation of axon extension
.cellular protein modification process
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.protein kinase activity
.cytoplasm
.nucleus
75 EBI-719493,EBI-8787606 FAM126B  
  .N/A .N/A .intracellular
76 EBI-719493,EBI-3957237 FANCM  
  .replication fork processing
.DNA repair
.resolution of meiotic recombination intermediates
.ATP binding
.nuclease activity
.helicase activity
  + 2 more...
.FANCM-MHF complex
.Fanconi anaemia nuclear complex
.nucleoplasm
77 EBI-719493,EBI-10265323 RIBC1  
  .N/A .N/A .N/A
78 EBI-719493,EBI-3439227 ZGPAT  
  .negative regulation of transcription, DNA-templated
.negative regulation of epidermal growth factor-activated receptor activity
.negative regulation of transcription from RNA polymerase II promoter
.metal ion binding
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.nucleus
79 EBI-719493,EBI-1166928 ATPAF2  
  .proton-transporting ATP synthase complex assembly .N/A .nuclear speck
.mitochondrion
80 EBI-719493,EBI-10220600 IQUB  
  .cilium morphogenesis
.smoothened signaling pathway
.N/A .motile cilium
.acrosomal vesicle
81 EBI-719493,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
82 EBI-719493,EBI-10274069 LGALS14  
  .positive regulation of T cell apoptotic process
.apoptotic process
.carbohydrate binding .nucleus
83 EBI-719493,EBI-746325 RHPN1  
  .regulation of catalytic activity
.small GTPase mediated signal transduction
.N/A .cytosol
84 EBI-719493,EBI-10175300 CCHCR1  
  .cell differentiation
.multicellular organismal development
.protein export from nucleus
.N/A .centriole
.cytoplasm
.nucleus
85 EBI-719493,EBI-10275006 GNPDA2  
  .N-acetylglucosamine metabolic process
.carbohydrate metabolic process
.hydrolase activity
.glucosamine-6-phosphate deaminase activity
.cytoplasm
.nucleus
86 EBI-719493,EBI-10244131 FBF1  
  .establishment of epithelial cell polarity
.apical junction assembly
.cilium assembly
.organelle organization
.N/A .ciliary transition fiber
.cell junction
.cytosol
  + 3 more...
87 EBI-719493,EBI-8637627 AEN  
  .nucleic acid phosphodiester bond hydrolysis
.intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.response to ionizing radiation
.exonuclease activity
.nucleic acid binding
.nuclear membrane
.nucleolus
.nucleoplasm
.nucleus
88 EBI-719493,EBI-7199479 PTPMT1  
  .inositol phosphate dephosphorylation
.glycerophospholipid biosynthetic process
.small molecule metabolic process
  + 4 more...
.phosphatidylglycerophosphatase activity
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
.integral component of mitochondrial inner membrane
.mitochondrion
.nucleus
89 EBI-719493,EBI-923440 GATAD2B  
  .ATP-dependent chromatin remodeling
.transcription, DNA-templated
.sequence-specific DNA binding
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.protein complex
.nuclear speck
.nucleoplasm
.nuclear chromatin
90 EBI-719493,EBI-399080 KAT5  
  .positive regulation of protein acetylation
.cellular response to estradiol stimulus
.positive regulation of transcription from RNA polymerase II promoter
  + 14 more...
.repressing transcription factor binding
.androgen receptor binding
.metal ion binding
  + 2 more...
.perinuclear region of cytoplasm
.NuA4 histone acetyltransferase complex
.Piccolo NuA4 histone acetyltransferase complex
  + 6 more...
91 EBI-719493,EBI-10281234 NEIL2  
  .depyrimidination
.nucleotide-excision repair
.base-excision repair, AP site formation
  + 2 more...
.hydrolase activity, hydrolyzing N-glycosyl compounds
.zinc ion binding
.DNA-(apurinic or apyrimidinic site) lyase activity
.damaged DNA binding
.spindle microtubule
.cytoplasm
.nucleoplasm
92 EBI-719493,EBI-2371750 GFM2  
  .mitochondrial translational termination
.ribosome disassembly
.mitochondrial translation
.organelle organization
.GTP binding
.GTPase activity
.mitochondrial matrix
93 EBI-719493,EBI-741068 FBXW5  
  .centrosome duplication
.proteasome-mediated ubiquitin-dependent protein catabolic process
.SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.protein kinase binding .Cul4-RING E3 ubiquitin ligase complex
.SCF ubiquitin ligase complex
.cytoplasm
94 EBI-719493,EBI-726510 LENG1  
  .N/A .N/A .N/A
95 EBI-719493,EBI-2514791 HAUS1  
  .cell division
.centrosome organization
.spindle assembly
.mitotic nuclear division
.N/A .HAUS complex
.microtubule
.centrosome
  + 2 more...
96 EBI-719493,EBI-746595 ZMYND19  
  .N/A .metal ion binding .synapse
.plasma membrane
.cytoplasm
97 EBI-719493,EBI-465804 DTNBP1  
  .membrane organization
.regulation of dopamine receptor signaling pathway
.platelet dense granule organization
  + 11 more...
.N/A .postsynaptic membrane
.dendritic spine
.neuron projection
  + 14 more...
98 EBI-719493,EBI-719955 LINGO1  
  .negative regulation of axonogenesis
.regulation of axonogenesis
.negative regulation of oligodendrocyte differentiation
  + 4 more...
.N/A .integral component of membrane
.plasma membrane
99 EBI-719493,EBI-745021 STAMBPL1  
  .N/A .metal ion binding
.metallopeptidase activity
.membrane
100 EBI-719493,EBI-7097057 CPNE2  
  .N/A .N/A .extracellular exosome
101 EBI-719493,EBI-10286106 LINC00526  
  .N/A .N/A .N/A
102 EBI-719493,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
103 EBI-719493,EBI-740773 RBM41  
  .N/A .RNA binding
.nucleotide binding
.N/A
104 EBI-719493,EBI-10292648 FAM193B  
  .N/A .N/A .cytoplasm
.nucleolus
.nucleoplasm
.nucleus
105 EBI-719493,EBI-2860740 PRAM1  
  .regulation of neutrophil degranulation
.integrin-mediated signaling pathway
.lipid binding .N/A
106 EBI-719493,EBI-3916225 FOXB1  
  .cell migration in diencephalon
.inferior colliculus development
.mammary gland lobule development
  + 19 more...
.sequence-specific DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
107 EBI-719493,EBI-1030678 BAG1  
  .regulation of cellular response to heat
.chaperone cofactor-dependent protein refolding
.negative regulation of apoptotic process
  + 4 more...
.receptor signaling protein activity .cytosol
.cytoplasm
.nucleus
108 EBI-719493,EBI-3956892 FOXC2  
  .negative regulation of apoptotic process involved in outflow tract morphogenesis
.positive regulation of cell migration involved in sprouting angiogenesis
.glomerular mesangial cell development
  + 34 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.chromatin DNA binding
  + 3 more...
.nucleus
109 EBI-719493,EBI-2849569 ZFYVE21  
  .N/A .metal ion binding .cytoplasmic membrane-bounded vesicle
.focal adhesion
.endosome
110 EBI-719493,EBI-1752811 FAM110A  
  .N/A .N/A .microtubule organizing center
.cytoplasm
.spindle pole
111 EBI-719493,EBI-741945 VPS25  
  .membrane organization
.protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
.endosomal transport
  + 2 more...
.protein N-terminus binding
.protein homodimerization activity
.structural molecule activity
.extracellular exosome
.endosome membrane
.cytosol
  + 6 more...
112 EBI-719493,EBI-5457544 UTP23  
  .maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) .small ribosomal subunit rRNA binding
.poly(A) RNA binding
.small-subunit processome
.nucleolus
113 EBI-719493,EBI-2568609 FAM64A  
  .cell division
.mitotic nuclear division
.N/A .cytoplasm
.nucleolus
.nucleus
114 EBI-719493,EBI-740781 TCHP  
  .negative regulation of cell growth
.apoptotic process
.N/A .apical cortex
.keratin filament
.plasma membrane
  + 3 more...
115 EBI-719493,EBI-744023 FAM103A1  
  .recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex
.methylation
.7-methylguanosine mRNA capping
.poly(A) RNA binding
.RNA binding
.mRNA cap binding complex
.nucleus
116 EBI-719493,EBI-5452779 POLR3C  
  .defense response to virus
.positive regulation of innate immune response
.innate immune response
  + 7 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase III complex
.nucleoplasm
.nucleus
117 EBI-719493,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
118 EBI-719493,EBI-744935 C20orf195  
  .N/A .N/A .extracellular exosome
119 EBI-719493,EBI-10300345 CCDC94  
  .N/A .N/A .N/A
120 EBI-719493,EBI-748391 SCNM1  
  .RNA splicing
.mRNA processing
.metal ion binding
.enzyme binding
.nuclear speck
.nucleolus
.nucleus
121 EBI-719493,EBI-745073 BEX2  
  .regulation of cell cycle
.regulation of apoptotic process
.cell cycle
.apoptotic process
.N/A .cytoplasm
.nucleus
122 EBI-719493,EBI-928842 NDEL1  
  .neuron projection extension
.neurofilament cytoskeleton organization
.centrosome localization
  + 20 more...
.oligopeptidase activity
.microtubule binding
.neurofilament cytoskeleton
.axon hillock
.cell leading edge
  + 10 more...
123 EBI-719493,EBI-372911 SPATC1L  
  .N/A .N/A .N/A
124 EBI-719493,EBI-745878 KIAA1683  
  .N/A .N/A .mitochondrion
.nucleus
125 EBI-719493,EBI-5464419 PUS7L  
  .tRNA processing
.pseudouridine synthesis
.pseudouridine synthase activity
.RNA binding
.N/A
126 EBI-719493,EBI-724478 PTPN23  
  .positive regulation of early endosome to late endosome transport
.positive regulation of adherens junction organization
.positive regulation of homophilic cell adhesion
  + 5 more...
.protein kinase binding
.protein tyrosine phosphatase activity
.extracellular exosome
.ciliary basal body
.cytoplasmic membrane-bounded vesicle
  + 5 more...
127 EBI-719493,EBI-742909 ARMC7  
  .N/A .N/A .cytoplasm
.nucleus
128 EBI-719493,EBI-747035 SH2D4A  
  .negative regulation of phosphatase activity .phosphatase binding .cytoplasm
129 EBI-719493,EBI-750907 CSRP2BP  
  .histone H3 acetylation
.chromatin organization
.G2/M transition of mitotic cell cycle
.LIM domain binding
.histone acetyltransferase activity
.cytoplasm
.Ada2/Gcn5/Ada3 transcription activator complex
.nucleus
130 EBI-719493,EBI-7445625 NOD2  
  .positive regulation of prostaglandin-E synthase activity
.negative regulation of macrophage apoptotic process
.positive regulation of cytokine production involved in inflammatory response
  + 81 more...
.CARD domain binding
.peptidoglycan binding
.muramyl dipeptide binding
  + 3 more...
.protein complex
.vesicle
.basolateral plasma membrane
  + 5 more...
131 EBI-719493,EBI-740364 NEK6  
  .regulation of cellular senescence
.spindle assembly
.protein autophosphorylation
  + 13 more...
.protein kinase binding
.kinesin binding
.ATP binding
  + 3 more...
.nuclear speck
.microtubule
.cytosol
  + 4 more...
132 EBI-719493,EBI-2557363 TUFT1  
  .odontogenesis
.bone mineralization
.structural constituent of tooth enamel .cytoplasm
.extracellular region
133 EBI-719493,EBI-1053902 MRPL40  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 3 more...
.poly(A) RNA binding .mitochondrial ribosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
134 EBI-719493,EBI-9679045 DMRT3  
  .male sex differentiation
.regulation of odontogenesis of dentin-containing tooth
.ventral spinal cord interneuron specification
  + 4 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 2 more...
.nucleus
135 EBI-719493,EBI-10312733 ARHGEF3  
  .apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.neurotrophin TRK receptor signaling pathway
  + 4 more...
.Rho guanyl-nucleotide exchange factor activity .cytosol
.intracellular
136 EBI-719493,EBI-8787464 TBC1D22B  
  .N/A .GTPase activator activity .N/A
137 EBI-719493,EBI-717672 ABCF3  
  .defense response to virus .ATPase activity
.ATP binding
.membrane
138 EBI-719493,EBI-749261 CCDC87  
  .cytokinesis
.microtubule cytoskeleton organization
.N/A .N/A
139 EBI-719493,EBI-745725 BABAM1  
  .protein K63-linked deubiquitination
.positive regulation of DNA repair
.G2 DNA damage checkpoint
  + 3 more...
.N/A .BRISC complex
.BRCA1-A complex
.cytoplasm
  + 2 more...
140 EBI-719493,EBI-743375 CHCHD3  
  .mitochondrial fusion
.inner mitochondrial membrane organization
.negative regulation of transcription from RNA polymerase II promoter
.protein complex scaffold
.phosphatase binding
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.extracellular exosome
.mitochondrial inner membrane
.mitochondrion
  + 2 more...
141 EBI-719493,EBI-742842 USE1  
  .endoplasmic reticulum tubular network organization
.regulation of ER to Golgi vesicle-mediated transport
.secretion by cell
  + 4 more...
.N/A .integral component of membrane
.endoplasmic reticulum membrane
.endoplasmic reticulum
142 EBI-719493,EBI-10317491 MAT2B  
  .regulation of catalytic activity
.small molecule metabolic process
.methylation
  + 3 more...
.methionine adenosyltransferase regulator activity
.enzyme binding
.extracellular exosome
.methionine adenosyltransferase complex
.cytosol
  + 3 more...
143 EBI-719493,EBI-745520 ZNF581  
  .transcription from RNA polymerase II promoter
.regulation of transcription from RNA polymerase II promoter
.metal ion binding
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
144 EBI-719493,EBI-743428 RCOR3  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.chromatin binding
.DNA binding
.nucleus
145 EBI-719493,EBI-77889 MAD2L2  
  .negative regulation of transcription regulatory region DNA binding
.negative regulation of cell-cell adhesion mediated by cadherin
.negative regulation of canonical Wnt signaling pathway
  + 19 more...
.JUN kinase binding
.RNA polymerase II activating transcription factor binding
.zeta DNA polymerase complex
.spindle
.cytoplasm
  + 2 more...
146 EBI-719493,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
147 EBI-719493,EBI-396137 CDC23  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 11 more...
.ubiquitin-protein transferase activity .cytosol
.anaphase-promoting complex
.nucleoplasm
.intracellular
148 EBI-719493,EBI-356517 BAG5  
  .negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.regulation of cellular response to heat
.regulation of inclusion body assembly
  + 7 more...
.chaperone binding
.ubiquitin protein ligase binding
.protein kinase binding
.perinuclear region of cytoplasm
.inclusion body
.membrane
  + 3 more...
149 EBI-719493,EBI-744066 SPATA2  
  .cell differentiation
.spermatogenesis
.multicellular organismal development
.N/A .cytoplasm
.nucleolus
.nucleus
150 EBI-719493,EBI-766064 MTMR6  
  .potassium ion transmembrane transport
.phosphatidylinositol dephosphorylation
.small molecule metabolic process
  + 4 more...
.phosphatidylinositol phosphate phosphatase activity
.calcium-activated potassium channel activity
.protein tyrosine phosphatase activity
.protein serine/threonine phosphatase activity
.cytosol
.cytoplasm
.nuclear envelope
151 EBI-719493,EBI-10187270 AMOTL2  
  .hippo signaling
.Wnt signaling pathway
.N/A .recycling endosome
.cytoplasmic vesicle
.apical plasma membrane
  + 2 more...
152 EBI-719493,EBI-1104564 MEMO1  
  .regulation of microtubule-based process .N/A .cytosol
.nucleus
153 EBI-719493,EBI-750123 TPRKB  
  .tRNA processing .protein kinase binding .cytosol
.cytoplasm
.nucleus
154 EBI-719493,EBI-744782 NME7  
  .left/right pattern formation
.ciliary receptor clustering involved in smoothened signaling pathway
.intraciliary transport
  + 6 more...
.metal ion binding
.ATP binding
.nucleoside diphosphate kinase activity
.ciliary basal body
.centrosome
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland91
ascites150
bladder133
blood98
bone97
bone marrow82
brain40
cervix82
connective tissue60
ear124
embryonic tissue131
eye124
heart44
intestine81
kidney33
liver77
lung83
lymph338
lymph node100
mammary gland79
mouth15
muscle9
nerve64
ovary78
pancreas42
parathyroid145
pituitary gland121
placenta84
prostate94
salivary gland98
skin85
spleen18
stomach104
testis22
thymus12
thyroid64
tonsil58
uterus94
vascular19
Health State
TissuesTPM*
normal63
adrenal tumor158
bladder carcinoma113
breast (mammary gland) tumor107
cervical tumor57
chondrosarcoma156
colorectal tumor115
gastrointestinal tumor143
germ cell tumor87
glioma93
head and neck tumor37
kidney tumor43
leukemia105
liver tumor114
lung tumor97
lymphoma249
non-neoplasia31
ovarian tumor65
pancreatic tumor76
primitive neuroectodermal tumor of the CNS62
prostate cancer96
retinoblastoma129
skin tumor135
soft tissue/muscle tissue tumor39
uterine tumor133
Developmental Stage
TissuesTPM*
adult78
embryoid body128
blastocyst113
fetus96
infant42
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.8
adrenal gland21
appendix25.6
bone marrow7.3
cerebral cortex18.9
colon21.7
duodenum22.8
esophagus15.4
gallbladder23
heart muscle13.1
kidney15.7
liver17.1
lung23.2
lymph node29.2
ovary27.6
pancreas10.7
placenta23
prostate25.5
salivary gland19.6
skin18.5
small intestine19.4
spleen29.8
stomach21.7
testis14.1
thyroid gland29
urinary bladder26.6
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowLow
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexHigh
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2Low
epididymisHigh
esophagusMedium
fallopian tubeMedium
gallbladderHigh
heart muscleHigh
hippocampusHigh
kidneyHigh
lateral ventricleHigh
liverHigh
lungMedium
lymph nodeMedium
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasHigh
parathyroid glandHigh
placentaHigh
prostateMedium
rectumHigh
salivary glandHigh
seminal vesicleHigh
skeletal muscleMedium
skin 1High
skin 2Medium
small intestineHigh
soft tissue 1Medium
spleenLow
stomach 1High
stomach 2High
testisHigh
thyroid glandHigh
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#188550, phenotype) Thyroid carcinoma, papillaryOMIM
2(*602165, gene) Tripartite motif-containing protein 27; TRIM27OMIM
3papillary thyroidCGP


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