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> Protein (NX_P14618)
Protein (NX_P14618)
Protein
Gene SymbolPKM to neXtProt (NX_P14618)
DescriptionPyruvate kinase PKM
Chromosome15
Location15q23 (72491370 ~ 72524164) to Ensembl
Sequene Features : Isoforms 3, Variants 65, PTMs 51 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.canonical glycolysis
.small molecule metabolic process
.programmed cell death
  + 2 more...
.poly(A) RNA binding
.potassium ion binding
.MHC class II protein complex binding
  + 3 more...
.extracellular exosome
.vesicle
.extracellular matrix
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 65 51
2014-09-19protein level
3 46 51
2014-05-27protein level
3 44 53
2014-02-25protein level
3 43 45
2013-12-09protein level
3 23 45
2013-11-01protein level
3 22 41
2013-09-12protein level
3 22 41
2013-08-17protein level
3 22 41
2013-07-15protein level
3 11 25
2013-06-11protein level
3 11 25
2013-02-12protein level
3 5 60
2012-12-20protein level
3 6 57
2012-10-30protein level
3 10 57
2012-10-07protein level
3 10 22
2012-08-24protein level
3 10 22
2012-07-28protein level
3 10 22
2012-06-08protein level
3 22 22
2012-05-07protein level
3 22 22
2012-04-10protein level
2 22 22
2012-01-13protein level
2 24 22
2011-12-20protein level
2 22 20
2011-11-11protein level
2 22 17
2011-08-23protein level
2 22 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P14618-1
0 26 1 57899.856
NX_P14618-2
3 23 1 58024.7624
NX_P14618-3
2 22 1 56237.1021
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-353408,EBI-365996 RAF1  
  .regulation of cell motility
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.death-inducing signaling complex assembly
  + 36 more...
.metal ion binding
.identical protein binding
.ATP binding
  + 3 more...
.pseudopodium
.plasma membrane
.cytosol
  + 4 more...
2 EBI-353408,EBI-365961 ARAF  
  .negative regulation of apoptotic process
.positive regulation of peptidyl-serine phosphorylation
.regulation of proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.metal ion binding
.ATP binding
.receptor signaling protein activity
  + 2 more...
.N/A
3 EBI-4304679,EBI-73995 MAPK3  
  .negative regulation of apolipoprotein binding
.regulation of early endosome to late endosome transport
.regulation of cellular response to heat
  + 62 more...
.phosphatase binding
.ATP binding
.MAP kinase activity
.extracellular exosome
.pseudopodium
.microtubule cytoskeleton
  + 11 more...
4 EBI-353408,EBI-714559 ARRB2  
  .positive regulation of DNA biosynthetic process
.negative regulation of release of cytochrome c from mitochondria
.positive regulation of ERK1 and ERK2 cascade
  + 35 more...
.protein complex scaffold
.angiotensin receptor binding
.ubiquitin protein ligase binding
  + 3 more...
.postsynaptic membrane
.dendritic spine
.cytoplasmic vesicle
  + 8 more...
5 EBI-353408,EBI-466029 HTT  
  .negative regulation of extrinsic apoptotic signaling pathway
.iron ion homeostasis
.L-glutamate import
  + 38 more...
.diazepam binding
.beta-tubulin binding
.dynein intermediate chain binding
  + 6 more...
.protein complex
.cytoplasmic vesicle membrane
.dendrite
  + 11 more...
6 EBI-353408,EBI-743313 ARRB1  
  .positive regulation of histone H4 acetylation
.positive regulation of ERK1 and ERK2 cascade
.membrane organization
  + 24 more...
.transcription regulatory region DNA binding
.cysteine-type endopeptidase inhibitor activity involved in apoptotic process
.angiotensin receptor binding
  + 5 more...
.cytoplasmic vesicle
.pseudopodium
.cytoplasmic vesicle membrane
  + 9 more...
7 EBI-353408,EBI-358616 DAPK1  
  .regulation of N-methyl-D-aspartate selective glutamate receptor activity
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.extrinsic apoptotic signaling pathway in absence of ligand
  + 13 more...
.identical protein binding
.syntaxin-1 binding
.GTP binding
  + 5 more...
.actin cytoskeleton
.plasma membrane
.cytoplasm
8 EBI-4304679,EBI-79722 HIST1H3A  
  .regulation of gene silencing
.protein heterotetramerization
.negative regulation of gene expression, epigenetic
  + 10 more...
.histone binding
.DNA binding
.extracellular exosome
.protein complex
.membrane
  + 6 more...
9 EBI-4304679,EBI-447269 HIF1A  
  .negative regulation of mesenchymal cell apoptotic process
.negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
.dopaminergic neuron differentiation
  + 62 more...
.Hsp90 protein binding
.protein heterodimerization activity
.sequence-specific DNA binding
  + 12 more...
.RNA polymerase II transcription factor complex
.motile cilium
.nuclear speck
  + 6 more...
10 EBI-4304679,EBI-1175354 EGLN3  
  .cellular response to hypoxia
.regulation of transcription from RNA polymerase II promoter in response to hypoxia
.regulation of neuron apoptotic process
  + 7 more...
.peptidyl-proline 4-dioxygenase activity
.L-ascorbic acid binding
.oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
.iron ion binding
.cytosol
.cytoplasm
.nucleoplasm
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue155
adrenal gland1669
ascites3313
bladder904
blood1096
bone1228
bone marrow1025
cervix2392
connective tissue1804
ear62
embryonic tissue1146
esophagus1240
eye1264
heart1117
intestine1448
kidney2680
larynx894
liver983
lung1284
lymph4063
lymph node367
mammary gland1163
mouth1723
muscle1466
nerve450
ovary2827
pancreas1630
parathyroid97
pharynx294
pituitary gland544
placenta671
prostate1366
salivary gland3750
skin3672
spleen1535
stomach992
testis1229
thymus1053
thyroid1502
tonsil2408
trachea579
umbilical cord1671
uterus1184
vascular1839
Health State
TissuesTPM*
adrenal tumor1027
bladder carcinoma682
breast (mammary gland) tumor1525
cervical tumor3189
chondrosarcoma1738
colorectal tumor2248
esophageal tumor1275
gastrointestinal tumor1924
germ cell tumor2564
glioma4263
head and neck tumor1741
kidney tumor4559
leukemia1016
liver tumor1843
lung tumor2559
lymphoma2964
non-neoplasia1635
ovarian tumor2874
pancreatic tumor3037
primitive neuroectodermal tumor of the CNS3283
prostate cancer1771
retinoblastoma1959
skin tumor4027
soft tissue/muscle tissue tumor1796
uterine tumor1131
Developmental Stage
TissuesTPM*
embryoid body1143
blastocyst1285
neonate4570
fetus477
infant3402
juvenile3256
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue148.7
adrenal gland297.7
appendix353.6
bone marrow290.1
cerebral cortex338.2
colon210.3
duodenum178.5
esophagus426.5
gallbladder264.6
heart muscle445.8
kidney286.1
liver29.4
lung207.9
lymph node297.3
ovary161.1
pancreas56.2
placenta188.4
prostate228.9
salivary gland161
skin333
small intestine171.3
spleen179.7
stomach182.3
testis203.4
thyroid gland182.2
urinary bladder414
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowLow
breastLow
bronchusHigh
cerebral cortexMedium
cervix, uterineMedium
colonLow
duodenumMedium
endometrium 1Medium
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeHigh
gallbladderHigh
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungHigh
lymph nodeHigh
nasopharynxMedium
oral mucosaMedium
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumMedium
salivary glandLow
seminal vesicleMedium
skin 1Medium
skin 2Medium
small intestineMedium
soft tissue 1High
spleenHigh
stomach 1Medium
stomach 2High
testisHigh
thyroid glandMedium
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*179050, gene) Pyruvate kinase, muscle, 2; PKM2OMIM


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