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> Protein (NX_P14678)
Protein (NX_P14678)
Protein
Gene SymbolSNRPB to neXtProt (NX_P14678)
DescriptionSmall nuclear ribonucleoprotein-associated proteins B and B'
Chromosome20
Location20p13 (2442280 ~ 2451499) to Ensembl
Sequene Features : Isoforms 3, Variants 34, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.activation of mitophagy in response to mitochondrial depolarization
.ncRNA metabolic process
.mRNA 3'-end processing
  + 9 more...
.histone pre-mRNA DCP binding
.poly(A) RNA binding
.histone pre-mRNA 3'end processing complex
.catalytic step 2 spliceosome
.U2-type prespliceosome
  + 14 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 34 8
2014-09-19protein level
3 23 8
2014-05-27protein level
3 23 14
2014-02-25protein level
3 22 12
2013-12-09protein level
3 22 12
2013-11-01protein level
3 21 11
2013-09-12protein level
3 21 11
2013-08-17protein level
3 21 11
2013-07-15protein level
3 13 7
2013-06-11protein level
3 13 7
2013-02-12protein level
3 4 12
2012-12-20protein level
3 4 12
2012-10-30protein level
3 4 12
2012-10-07protein level
3 4 4
2012-08-24protein level
3 2 4
2012-07-28protein level
3 2 4
2012-06-08protein level
3 4 4
2012-05-07protein level
3 4 4
2012-04-10protein level
3 4 4
2012-01-13protein level
3 4 4
2011-12-20protein level
3 4 4
2011-11-11protein level
3 4 4
2011-08-23protein level
3 4 4
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P14678-1
0 6 6 24593.615
NX_P14678-2
0 6 5 23640.1524
NX_P14678-3
3 5 5 30012.0435
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-372475,EBI-744674 SS18L1  
  .positive regulation of dendrite morphogenesis
.positive regulation of transcription, DNA-templated
.chromatin modification
  + 2 more...
.N/A .nBAF complex
.nuclear body
.nucleus
  + 3 more...
2 EBI-372475,EBI-7875264 DAB1  
  .lateral motor column neuron migration
.Golgi localization
.negative regulation of axonogenesis
  + 15 more...
.N/A .perinuclear region of cytoplasm
.apical part of cell
.neuronal cell body
  + 5 more...
3 EBI-372475,EBI-768015 CD2BP2  
  .negative regulation of phosphatase activity
.gene expression
.RNA splicing
  + 2 more...
.ribonucleoprotein complex binding .cytoplasm
.U5 snRNP
.nucleoplasm
.nucleus
4 EBI-372475,EBI-348380 PSMA3  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.proteasome core complex
  + 5 more...
5 EBI-372475,EBI-740098 TRIM23  
  .positive regulation of catalytic activity
.protein ubiquitination
.viral process
.small GTPase mediated signal transduction
.identical protein binding
.GDP binding
.ligase activity
  + 5 more...
.extracellular exosome
.lysosomal membrane
.nucleus
.Golgi membrane
6 EBI-372458,EBI-724693 CLNS1A  
  .ncRNA metabolic process
.gene expression
.cell volume homeostasis
  + 2 more...
.protein heterodimerization activity
.poly(A) RNA binding
.pICln-Sm protein complex
.methylosome
.plasma membrane
  + 5 more...
7 EBI-372458,EBI-372789 SNRPD3  
  .ncRNA metabolic process
.mRNA 3'-end processing
.gene expression
  + 7 more...
.histone pre-mRNA DCP binding
.poly(A) RNA binding
.enzyme binding
.catalytic step 2 spliceosome
.extracellular exosome
.SMN-Sm protein complex
  + 11 more...
8 EBI-372475,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
9 EBI-372475,EBI-739580 CALCOCO2  
  .response to interferon-gamma
.viral process
.protein homodimerization activity .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.membrane
  + 4 more...
10 EBI-372471,EBI-395447 SMN2  
  .ncRNA metabolic process
.gene expression
.nervous system development
  + 2 more...
.identical protein binding
.RNA binding
.Gemini of coiled bodies
.SMN-Sm protein complex
.SMN complex
  + 7 more...
11 EBI-372475,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
12 EBI-372475,EBI-746118 RFX6  
  .pancreatic epsilon cell differentiation
.regulation of insulin secretion
.positive regulation of transcription from RNA polymerase II promoter
  + 7 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
  + 2 more...
.nucleus
13 EBI-372475,EBI-744695 BANP  
  .negative regulation of protein catabolic process
.protein localization to nucleus
.chromatin modification
  + 4 more...
.DNA binding .nucleoplasm
14 EBI-372475,EBI-302345 PNMA1  
  .positive regulation of apoptotic process
.inflammatory response to antigenic stimulus
.N/A .focal adhesion
.cytoplasm
.nucleolus
15 EBI-372475,EBI-740322 RBPMS  
  .positive regulation of SMAD protein import into nucleus
.positive regulation of pathway-restricted SMAD protein phosphorylation
.RNA processing
  + 2 more...
.poly(A) RNA binding
.poly(A) binding
.transcription coactivator activity
.nucleotide binding
.cytoplasm
.nucleoplasm
16 EBI-372475,EBI-2686809 L3MBTL3  
  .erythrocyte maturation
.granulocyte differentiation
.macrophage differentiation
  + 3 more...
.N/A .nucleus
17 EBI-372475,EBI-1105213 TFIP11  
  .biomineral tissue development
.RNA processing
.regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .catalytic step 2 spliceosome
.U2-type post-mRNA release spliceosomal complex
.nuclear speck
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue621
adrenal gland303
ascites476
bladder167
blood441
bone265
bone marrow61
brain129
cervix329
connective tissue100
embryonic tissue516
esophagus49
eye363
heart178
intestine280
kidney270
larynx42
liver316
lung474
lymph541
lymph node278
mammary gland231
mouth15
muscle319
nerve128
ovary423
pancreas398
parathyroid582
pharynx24
pituitary gland60
placenta335
prostate342
salivary gland888
skin915
spleen56
stomach355
testis48
thymus62
thyroid21
tonsil1586
trachea19
umbilical cord145
uterus357
vascular77
Health State
TissuesTPM*
normal130
adrenal tumor711
bladder carcinoma284
breast (mammary gland) tumor354
cervical tumor347
chondrosarcoma169
colorectal tumor355
esophageal tumor57
gastrointestinal tumor506
germ cell tumor467
glioma363
head and neck tumor156
kidney tumor667
leukemia285
liver tumor583
lung tumor1167
lymphoma387
non-neoplasia93
ovarian tumor341
pancreatic tumor638
primitive neuroectodermal tumor of the CNS692
prostate cancer529
retinoblastoma990
skin tumor1491
soft tissue/muscle tissue tumor526
uterine tumor477
Developmental Stage
TissuesTPM*
adult155
embryoid body471
blastocyst520
neonate32
fetus127
infant85
juvenile143
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue51.9
adrenal gland56.8
appendix87.4
bone marrow163.4
cerebral cortex23.4
colon76
duodenum75.7
esophagus89
gallbladder58.4
heart muscle38.6
kidney42.8
liver26.2
lung61.5
lymph node131.8
ovary54.3
pancreas27.8
placenta74.2
prostate55
salivary gland55.3
skin80.7
small intestine68.3
spleen80.5
stomach67.9
testis61.4
thyroid gland55.1
urinary bladder73.8
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*182282, gene) Small nuclear ribonucleoprotein polypeptides b and b1; SNRPBOMIM


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