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> Protein (NX_P14780)
Protein (NX_P14780)
Protein
Gene SymbolMMP9 to neXtProt (NX_P14780)
DescriptionMatrix metalloproteinase-9
Chromosome20
Location20q13.12 (44637547 ~ 44645200) to Ensembl
Sequene Features : Isoforms 1, Variants 131, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.negative regulation of cation channel activity
.negative regulation of intrinsic apoptotic signaling pathway
  + 19 more...
.identical protein binding
.zinc ion binding
.metallopeptidase activity
  + 3 more...
.extracellular exosome
.extracellular space
.proteinaceous extracellular matrix
.extracellular region
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 131 10
2014-09-19protein level
1 106 10
2014-05-27protein level
1 106 10
2014-02-25protein level
1 106 10
2013-12-09protein level
1 78 10
2013-11-01protein level
1 75 10
2013-09-12protein level
1 75 10
2013-08-17protein level
1 75 10
2013-07-15protein level
1 58 10
2013-06-11protein level
1 58 10
2013-02-12protein level
1 29 10
2012-12-20protein level
1 28 10
2012-10-30protein level
1 29 10
2012-10-07protein level
1 29 10
2012-08-24protein level
1 28 10
2012-07-28protein level
1 28 10
2012-06-08protein level
1 31 10
2012-05-07protein level
1 24 10
2012-04-10protein level
1 24 10
2012-01-13protein level
1 20 10
2011-12-20protein level
1 20 10
2011-11-11protein level
1 20 10
2011-08-23protein level
1 20 10
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P14780-1
31 0 0 78408.1387
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1382326,EBI-712536 TIMP1  
  .regulation of integrin-mediated signaling pathway
.negative regulation of trophoblast cell migration
.negative regulation of membrane protein ectodomain proteolysis
  + 13 more...
.metal ion binding
.metalloendopeptidase inhibitor activity
.cytokine activity
.protease binding
.extracellular exosome
.platelet alpha granule lumen
.extracellular space
  + 3 more...
2 EBI-1382326,EBI-8515977 VCAN  
  .small molecule metabolic process
.dermatan sulfate biosynthetic process
.chondroitin sulfate catabolic process
  + 13 more...
.carbohydrate binding
.hyaluronic acid binding
.glycosaminoglycan binding
  + 2 more...
.intracellular membrane-bounded organelle
.lysosomal lumen
.extracellular matrix
  + 5 more...
3 EBI-1382326,EBI-8153734 MEP1A  
  .digestion .zinc ion binding
.metalloendopeptidase activity
.extracellular exosome
.meprin A complex
.integral component of plasma membrane
.extracellular space
4 EBI-1382326,EBI-968418 MEP1B  
  .toxin transport
.digestion
.inflammatory response
.zinc ion binding
.metalloendopeptidase activity
.integral component of plasma membrane
.plasma membrane
.extracellular space
5 EBI-1382326,EBI-4479975 SCUBE3  
  .protein heterooligomerization
.protein homooligomerization
.calcium ion binding .cell surface
.extracellular region
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
blood3345
bone125
bone marrow20
brain8
cervix20
connective tissue46
embryonic tissue75
esophagus198
eye14
intestine51
kidney4
liver4
lung29
lymph node55
mammary gland26
mouth181
ovary19
pancreas42
pharynx491
prostate5
spleen355
stomach10
testis4
thymus200
tonsil235
trachea57
uterus17
Health State
TissuesTPM*
normal228
adrenal tumor79
breast (mammary gland) tumor32
cervical tumor28
chondrosarcoma24
colorectal tumor8
esophageal tumor173
germ cell tumor53
glioma46
head and neck tumor239
kidney tumor14
leukemia1111
liver tumor10
lung tumor19
lymphoma69
non-neoplasia82
ovarian tumor39
pancreatic tumor76
soft tissue/muscle tissue tumor119
uterine tumor44
Developmental Stage
TissuesTPM*
adult64
embryoid body228
neonate10331
fetus1
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.6
appendix47.4
bone marrow181.8
colon7.1
duodenum8.8
esophagus2.1
gallbladder3.1
liver2.7
lung4.2
lymph node81.3
placenta1.4
prostate1.3
salivary gland2.4
skin2.2
small intestine9.6
spleen25.7
stomach11.7
testis1.3
thyroid gland1.6
urinary bladder17.5
Tissues
TissuesExpression level
bone marrowHigh
lymph nodeMedium
spleenHigh
tonsilMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*120361, gene) Matrix metalloproteinase 9; MMP9OMIM
2(#603932, phenotype) Intervertebral disc disease; IDDOMIM
3(#613073, phenotype) Metaphyseal anadysplasia 2; MANDP2OMIM


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