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> Protein (NX_P14921)
Protein (NX_P14921)
Protein
Gene SymbolETS1 to neXtProt (NX_P14921)
DescriptionProtein C-ets-1
Chromosome11
Location11q24.3 (128328656 ~ 128457453) to Ensembl
Sequene Features : Isoforms 5, Variants 71, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.response to interleukin-1
.cellular response to hydrogen peroxide
.angiogenesis involved in wound healing
  + 24 more...
.sequence-specific DNA binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
  + 2 more...
.intercellular bridge
.cytoplasm
.transcription factor complex
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 71 17
2014-09-19protein level
5 53 17
2014-05-27protein level
4 52 18
2014-02-25protein level
4 52 18
2013-12-09protein level
4 48 18
2013-11-01protein level
4 47 17
2013-09-12protein level
4 47 17
2013-08-17protein level
4 47 17
2013-07-15protein level
4 28 12
2013-06-11protein level
4 28 12
2013-02-12protein level
3 15 28
2012-12-20protein level
3 15 28
2012-10-30protein level
3 16 28
2012-10-07protein level
3 16 12
2012-08-24protein level
3 4 12
2012-07-28protein level
3 4 12
2012-06-08protein level
3 7 12
2012-05-07protein level
3 7 12
2012-04-10protein level
2 7 12
2012-01-13protein level
2 4 12
2011-12-20protein level
2 4 12
2011-11-11protein level
2 4 11
2011-08-23protein level
2 4 11
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P14921-1
0 19 1 50375.6435
NX_P14921-2
1 15 1 40760.0769
NX_P14921-3
3 17 1 55376.5026
NX_P14921-4
1 7 1 25680.8175
NX_P14921-5
1 13 0 30839.8563
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-913209,EBI-1210694 MEIS1  
  .definitive hemopoiesis
.negative regulation of neuron differentiation
.negative regulation of myeloid cell differentiation
  + 3 more...
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
.chromatin binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.transcription factor complex
.nucleus
2 EBI-913209,EBI-928530 EIF5B  
  .cellular protein metabolic process
.gene expression
.regulation of translational initiation
  + 2 more...
.poly(A) RNA binding
.GTP binding
.GTPase activity
.translation initiation factor activity
.cytosol
.cytoplasm
3 EBI-913209,EBI-852823 JUN  
  .positive regulation of DNA-templated transcription, initiation
.negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.cellular response to calcium ion
  + 60 more...
.R-SMAD binding
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 15 more...
.transcriptional repressor complex
.cytosol
.nuclear euchromatin
  + 4 more...
4 EBI-913224,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
5 EBI-913209,EBI-1753878 TAL1  
  .regulation of stem cell maintenance
.regulation of mast cell differentiation
.hematopoietic stem cell differentiation
  + 25 more...
.E-box binding
.transcription regulatory region DNA binding
.histone deacetylase binding
  + 8 more...
.transcription factor complex
.nucleus
.nuclear chromatin
6 EBI-913209,EBI-751145 SP100  
  .negative regulation of nucleic acid-templated transcription
.regulation of Fas signaling pathway
.regulation of extrinsic apoptotic signaling pathway via death domain receptors
  + 27 more...
.chromo shadow domain binding
.protein homodimerization activity
.identical protein binding
  + 7 more...
.nuclear periphery
.PML body
.cytoplasm
  + 3 more...
7 EBI-913209,EBI-959949 MAPK1  
  .regulation of early endosome to late endosome transport
.regulation of cellular response to heat
.cellular response to granulocyte macrophage colony-stimulating factor stimulus
  + 70 more...
.phosphatase binding
.RNA polymerase II carboxy-terminal domain kinase activity
.ATP binding
  + 3 more...
.mitotic spindle
.extracellular exosome
.protein complex
  + 17 more...
8 EBI-913209,EBI-352053 PRKDC  
  .signal transduction involved in mitotic G1 DNA damage checkpoint
.rhythmic process
.positive regulation of transcription from RNA polymerase II promoter
  + 27 more...
.poly(A) RNA binding
.transcription factor binding
.ATP binding
  + 4 more...
.nonhomologous end joining complex
.membrane
.DNA-dependent protein kinase-DNA ligase 4 complex
  + 4 more...
9 EBI-913209,EBI-1051785 SRSF11  
  .mRNA 3'-end processing
.gene expression
.RNA splicing
  + 5 more...
.poly(A) RNA binding
.nucleotide binding
.nucleoplasm
.nucleus
10 EBI-913209,EBI-79306 APLP2  
  .neuromuscular process controlling balance
.regulation of protein binding
.midbrain development
  + 9 more...
.transition metal ion binding
.identical protein binding
.heparin binding
  + 2 more...
.extracellular exosome
.integral component of membrane
.membrane
  + 2 more...
11 EBI-913209,EBI-2680990 ARID4B  
  .establishment of Sertoli cell barrier
.positive regulation of transcription from RNA polymerase II promoter
.negative regulation of gene expression, epigenetic
  + 9 more...
.transcription regulatory region DNA binding .cytoplasm
.nucleoplasm
.nucleus
12 EBI-913224,EBI-1176214 RFWD2  
  .positive regulation of proteasomal ubiquitin-dependent protein catabolic process
.response to ionizing radiation
.DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
.ubiquitin protein ligase activity
.ligase activity
.zinc ion binding
.nuclear speck
.focal adhesion
.cytosol
  + 4 more...
13 EBI-913209,EBI-2680384 C17orf62  
  .N/A .N/A .integral component of membrane
14 EBI-913224,EBI-287635 DAXX  
  .positive regulation of apoptotic signaling pathway
.positive regulation of neuron death
.negative regulation of transcription, DNA-templated
  + 13 more...
.androgen receptor binding
.protein N-terminus binding
.protein homodimerization activity
  + 10 more...
.SWI/SNF superfamily-type complex
.PML body
.cytosol
  + 5 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
bladder66
blood114
bone13
bone marrow61
brain7
connective tissue60
embryonic tissue61
eye9
heart22
intestine25
kidney33
larynx42
liver63
lung62
lymph90
lymph node311
mammary gland119
mouth30
muscle65
nerve128
pancreas51
pharynx73
placenta21
prostate5
skin90
stomach41
testis6
thymus112
thyroid42
uterus30
vascular19
Health State
TissuesTPM*
normal45
bladder carcinoma56
breast (mammary gland) tumor85
chondrosarcoma48
colorectal tumor26
gastrointestinal tumor33
germ cell tumor11
glioma9
head and neck tumor29
kidney tumor14
leukemia127
liver tumor72
lung tumor58
lymphoma69
non-neoplasia41
pancreatic tumor9
primitive neuroectodermal tumor of the CNS7
skin tumor31
soft tissue/muscle tissue tumor31
uterine tumor22
Developmental Stage
TissuesTPM*
adult45
embryoid body100
blastocyst48
fetus32
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue77.6
adrenal gland18.3
appendix129.7
bone marrow20.1
cerebral cortex12.7
colon29.1
duodenum22.4
esophagus21.1
gallbladder63.3
heart muscle32.4
kidney27.3
liver27.3
lung70.5
lymph node228.7
ovary25
pancreas8.6
placenta40.7
prostate14.8
salivary gland11.7
skin13.9
small intestine34
spleen148.6
stomach42.4
testis9.3
thyroid gland39
urinary bladder64.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*164720, gene) V-ets avian erythroblastosis virus e26 oncogene homolog 1; ETS1OMIM


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