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> Protein (NX_P15036)
Protein (NX_P15036)
Protein
Gene SymbolETS2 to neXtProt (NX_P15036)
DescriptionProtein C-ets-2
Chromosome21
Location21q22.2 (40177231 ~ 40196879) to Ensembl
Sequene Features : Isoforms 1, Variants 67, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.cell differentiation
  + 4 more...
.sequence-specific DNA binding transcription factor activity
.DNA binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
  + 2 more...
.nucleoplasm
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 67 3
2014-09-19protein level
1 50 3
2014-05-27protein level
1 50 2
2014-02-25protein level
1 49 2
2013-12-09protein level
1 39 2
2013-11-01protein level
1 37 2
2013-09-12protein level
1 37 2
2013-08-17protein level
1 37 2
2013-07-15protein level
1 24 1
2013-06-11protein level
1 24 1
2013-02-12protein level
1 13 1
2012-12-20protein level
1 16 1
2012-10-30protein level
1 20 1
2012-10-07protein level
1 20 1
2012-08-24protein level
1 18 1
2012-07-28protein level
1 18 1
2012-06-08protein level
1 18 1
2012-05-07protein level
1 13 1
2012-04-10protein level
1 13 1
2012-01-13protein level
1 14 1
2011-12-20protein level
1 14 1
2011-11-11protein level
1 14 1
2011-08-23protein level
1 14 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P15036-1
14 0 1 52967.6284
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1646991,EBI-1646959 CDK10  
  .positive regulation of MAPK cascade
.negative regulation of cell proliferation
.traversing start control point of mitotic cell cycle
.ATP binding
.cyclin-dependent protein serine/threonine kinase activity
.N/A
2 EBI-1646991,EBI-1797287 TWIST1  
  .positive regulation of endocardial cushion to mesenchymal transition involved in heart valve formation
.cell proliferation involved in heart valve development
.negative regulation of double-strand break repair
  + 51 more...
.E-box binding
.bHLH transcription factor binding
.transcription factor binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.nucleus
3 EBI-1646991,EBI-1797313 TWIST2  
  .cornea development in camera-type eye
.face morphogenesis
.embryonic cranial skeleton morphogenesis
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.DNA binding
.RNA polymerase II transcription factor binding transcription factor activity
.cytoplasm
.transcription factor complex
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue544
adrenal gland30
ascites50
bladder301
blood155
bone55
bone marrow123
brain93
cervix164
connective tissue120
ear62
embryonic tissue28
esophagus198
eye57
heart122
intestine211
kidney47
larynx340
liver175
lung173
lymph node111
mammary gland46
mouth256
muscle9
nerve128
ovary88
pancreas238
parathyroid97
pharynx73
pituitary gland60
placenta120
prostate58
salivary gland197
skin47
spleen56
stomach250
testis22
thymus125
thyroid21
trachea521
uterus168
vascular154
Health State
TissuesTPM*
normal104
bladder carcinoma284
breast (mammary gland) tumor32
cervical tumor115
chondrosarcoma169
colorectal tumor186
esophageal tumor231
gastrointestinal tumor168
germ cell tumor79
glioma121
head and neck tumor201
kidney tumor29
leukemia127
liver tumor72
lung tumor38
lymphoma13
non-neoplasia72
ovarian tumor78
pancreatic tumor285
primitive neuroectodermal tumor of the CNS23
prostate cancer19
soft tissue/muscle tissue tumor31
uterine tumor155
Developmental Stage
TissuesTPM*
adult126
embryoid body14
blastocyst32
neonate128
fetus102
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue56.7
adrenal gland23.4
appendix71
bone marrow61.1
cerebral cortex33.4
colon97.7
duodenum86.3
esophagus62.2
gallbladder95.9
heart muscle23.8
kidney26.6
liver121.1
lung89.4
lymph node29
ovary25.7
pancreas13.6
placenta43.1
prostate31
salivary gland12.2
skin49.9
small intestine116.4
spleen137
stomach30.6
testis6.9
thyroid gland26.5
urinary bladder82.1
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*164740, gene) V-ets avian erythroblastosis virus e26 oncogene homolog 2; ETS2OMIM


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