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> Protein (NX_P15056)
Protein (NX_P15056)
Protein
Gene SymbolBRAF to neXtProt (NX_P15056)
DescriptionSerine/threonine-protein kinase B-raf
Chromosome7
Location7q34 (140419127 ~ 140624564) to Ensembl
Sequene Features : Isoforms 1, Variants 260, PTMs 15 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of endothelial cell apoptotic process
.negative regulation of synaptic vesicle exocytosis
.positive regulation of substrate adhesion-dependent cell spreading
  + 28 more...
.identical protein binding
.ATP binding
.calcium ion binding
  + 3 more...
.cell body
.neuron projection
.plasma membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 260 15
2014-09-19protein level
1 229 15
2014-05-27protein level
1 229 16
2014-02-25protein level
1 143 16
2013-12-09protein level
1 140 16
2013-11-01protein level
1 140 15
2013-09-12protein level
1 140 15
2013-08-17protein level
1 140 15
2013-07-15protein level
1 139 15
2013-06-11protein level
1 139 15
2013-02-12protein level
1 139 18
2012-12-20protein level
1 139 18
2012-10-30protein level
1 139 18
2012-10-07protein level
1 139 18
2012-08-24protein level
1 53 18
2012-07-28protein level
1 54 18
2012-06-08protein level
1 56 18
2012-05-07protein level
1 55 17
2012-04-10protein level
1 55 17
2012-01-13protein level
1 51 17
2011-12-20protein level
1 51 16
2011-11-11protein level
1 51 15
2011-08-23protein level
1 51 15
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P15056-1
24 0 6 84383.3522
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-365980,EBI-365996 RAF1  
  .regulation of cell motility
.negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
.death-inducing signaling complex assembly
  + 36 more...
.metal ion binding
.identical protein binding
.ATP binding
  + 3 more...
.pseudopodium
.plasma membrane
.cytosol
  + 4 more...
2 EBI-365980,EBI-352572 HSP90AB1  
  .regulation of cellular response to heat
.fibril organization
.cellular response to interleukin-4
  + 14 more...
.poly(A) RNA binding
.TPR domain binding
.nitric-oxide synthase regulator activity
  + 4 more...
.extracellular exosome
.melanosome
.membrane
  + 4 more...
3 EBI-365980,EBI-365961 ARAF  
  .negative regulation of apoptotic process
.positive regulation of peptidyl-serine phosphorylation
.regulation of proteasomal ubiquitin-dependent protein catabolic process
  + 2 more...
.metal ion binding
.ATP binding
.receptor signaling protein activity
  + 2 more...
.N/A
4 EBI-365980,EBI-359815 YWHAB  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.membrane organization
  + 24 more...
.phosphoprotein binding
.phosphoserine binding
.histone deacetylase binding
  + 3 more...
.extracellular exosome
.perinuclear region of cytoplasm
.melanosome
  + 7 more...
5 EBI-365980,EBI-347088 YWHAZ  
  .positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
.intrinsic apoptotic signaling pathway
.Golgi reassembly
  + 14 more...
.poly(A) RNA binding
.identical protein binding
.ubiquitin protein ligase binding
  + 2 more...
.blood microparticle
.extracellular exosome
.perinuclear region of cytoplasm
  + 13 more...
6 EBI-365980,EBI-492564 MAP2K1  
  .regulation of early endosome to late endosome transport
.activation of mitophagy in response to mitochondrial depolarization
.cellular senescence
  + 55 more...
.protein N-terminus binding
.protein serine/threonine kinase activator activity
.protein C-terminus binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.perikaryon
  + 15 more...
7 EBI-365980,EBI-357631 TRAF3  
  .regulation of defense response to virus
.innate immune response
.regulation of apoptotic process
  + 14 more...
.thioesterase binding
.ubiquitin protein ligase binding
.ligase activity
  + 4 more...
.CD40 receptor complex
.cytoplasmic side of plasma membrane
.cytosol
  + 2 more...
8 EBI-365980,EBI-49776 MAP3K1  
  .cellular response to mechanical stimulus
.eyelid development in camera-type eye
.stress-activated MAPK cascade
  + 21 more...
.protein kinase binding
.JUN kinase kinase activity
.zinc ion binding
  + 3 more...
.cytosol
.cytoplasm
9 EBI-365980,EBI-1384149 RPS6KA2  
  .cellular response to carbohydrate stimulus
.regulation of protein processing
.heart contraction
  + 31 more...
.ATP binding
.protein serine/threonine/tyrosine kinase activity
.ribosomal protein S6 kinase activity
  + 2 more...
.nuclear membrane
.cytosol
.spindle
  + 3 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
ascites50
bladder33
blood8
bone27
brain1
cervix20
connective tissue33
embryonic tissue28
eye28
intestine25
kidney33
larynx42
lung8
lymph node66
mammary gland33
muscle37
pancreas4
placenta7
prostate15
skin14
testis2
thymus12
Health State
TissuesTPM*
normal1
breast (mammary gland) tumor42
cervical tumor28
chondrosarcoma12
colorectal tumor44
gastrointestinal tumor8
germ cell tumor3
glioma9
kidney tumor14
lung tumor19
pancreatic tumor9
primitive neuroectodermal tumor of the CNS39
prostate cancer28
retinoblastoma43
skin tumor23
soft tissue/muscle tissue tumor31
Developmental Stage
TissuesTPM*
adult2
embryoid body14
blastocyst48
neonate32
fetus5
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.3
adrenal gland9.3
appendix9.9
bone marrow15.6
cerebral cortex13.9
colon7.8
duodenum6.3
esophagus9.5
gallbladder10.1
heart muscle7.6
kidney9.5
liver6.3
lung8.5
lymph node10.7
ovary12.6
pancreas4.8
placenta10.3
prostate11.1
salivary gland5
skin9.3
small intestine6.6
spleen9.5
stomach8.8
testis26.6
thyroid gland13.4
urinary bladder11.3
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1High
endometrium 2High
epididymisMedium
esophagusLow
fallopian tubeHigh
gallbladderMedium
heart muscleLow
hippocampusMedium
kidneyMedium
lateral ventricleLow
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaHigh
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleHigh
skeletal muscleLow
skin 1Medium
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenLow
stomach 1Medium
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#114500, phenotype) Colorectal cancer; CRCOMIM
2(#115150, phenotype) Cardiofaciocutaneous syndromeOMIM
3(*164757, gene) V-raf murine sarcoma viral oncogene homolog b1; BRAFOMIM
4(#211980, phenotype) Lung cancerOMIM
5(#605027, phenotype) Lymphoma, non-hodgkin, familialOMIM
6(#613706, phenotype) Noonan syndrome 7; NS7OMIM
7(#613707, phenotype) Leopard syndrome 3OMIM
8melanoma;colorectal;papillary thyroid;borderline ov;Non small-cell lung cancer (NSCLC);cholangiocarcinoma;pilocytic astrocytoma;Cardio-facio-cutaneous syndromeCGP


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