Home| Contact Us

HOME SEARCH STATISTICS
> Protein (NX_P15336)
Protein (NX_P15336)
Protein
Gene SymbolATF2 to neXtProt (NX_P15336)
DescriptionCyclic AMP-dependent transcription factor ATF-2
Chromosome2
Location2q31.1 (175936978 ~ 176033110) to Ensembl
Sequene Features : Isoforms 8, Variants 63, PTMs 17 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.positive regulation of mitochondrial membrane permeability involved in apoptotic process
.adipose tissue development
.stress-activated MAPK cascade
  + 27 more...
.metal ion binding
.cAMP response element binding
.protein kinase binding
  + 13 more...
.site of double-strand break
.mitochondrial outer membrane
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
8 63 17
2014-09-19protein level
8 47 17
2014-05-27protein level
8 43 18
2014-02-25protein level
8 42 18
2013-12-09protein level
8 38 18
2013-11-01protein level
8 38 17
2013-09-12protein level
7 38 7
2013-08-17protein level
7 38 8
2013-07-15protein level
3 19 7
2013-06-11protein level
3 19 7
2013-02-12protein level
3 7 11
2012-12-20protein level
2 7 7
2012-10-30protein level
2 6 7
2012-10-07protein level
2 6 6
2012-08-24protein level
2 3 6
2012-07-28protein level
2 3 6
2012-06-08protein level
2 5 6
2012-05-07protein level
2 5 6
2012-04-10protein level
2 5 6
2012-01-13protein level
2 5 6
2011-12-20protein level
2 5 6
2011-11-11protein level
2 4 7
2011-08-23protein level
2 4 7
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P15336-1
0 16 1 54503.6024
NX_P15336-2
1 10 0 35022.7069
NX_P15336-3
1 5 1 23035.6064
NX_P15336-4
1 14 0 47983.2706
NX_P15336-5
0 16 1 52244.4354
NX_P15336-6
1 4 0 13140.252
NX_P15336-7
1 5 1 24082.0483
NX_P15336-8
1 4 0 15399.419
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-1170906,EBI-852851 FOS  
  .cellular response to calcium ion
.SMAD protein signal transduction
.response to cAMP
  + 44 more...
.R-SMAD binding
.transcription regulatory region DNA binding
.transcription factor binding
  + 3 more...
.neuron projection
.membrane
.cytosol
  + 4 more...
2 EBI-1170906,EBI-852823 JUN  
  .positive regulation of DNA-templated transcription, initiation
.negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.cellular response to calcium ion
  + 60 more...
.R-SMAD binding
.poly(A) RNA binding
.transcription regulatory region DNA binding
  + 15 more...
.transcriptional repressor complex
.cytosol
.nuclear euchromatin
  + 4 more...
3 EBI-1170906,EBI-713568 MAPK9  
  .positive regulation of apoptotic signaling pathway
.cellular response to growth factor stimulus
.cellular response to tumor necrosis factor
  + 45 more...
.cysteine-type endopeptidase activator activity involved in apoptotic process
.transcription factor binding
.ATP binding
.JUN kinase activity
.cytosol
.mitochondrion
.nucleoplasm
4 EBI-1170906,EBI-308629 HDAC4  
  .histone H4 deacetylation
.histone H3 deacetylation
.response to interleukin-1
  + 29 more...
.NAD-dependent histone deacetylase activity (H3-K18 specific)
.repressing transcription factor binding
.NAD-dependent histone deacetylase activity (H4-K16 specific)
  + 12 more...
.actomyosin
.A band
.neuromuscular junction
  + 7 more...
5 EBI-1170906,EBI-80140 SUMO1  
  .protein localization to nuclear pore
.regulation of interferon-gamma-mediated signaling pathway
.interferon-gamma-mediated signaling pathway
  + 13 more...
.poly(A) RNA binding
.ubiquitin protein ligase binding
.SUMO transferase activity
.transcription factor binding
.synapse
.nuclear membrane
.dendrite
  + 8 more...
6 EBI-1170906,EBI-2560599 SS18  
  .neuronal stem cell maintenance
.ephrin receptor signaling pathway
.positive regulation of transcription from RNA polymerase II promoter
  + 5 more...
.ligand-dependent nuclear receptor transcription coactivator activity .npBAF complex
.cytoplasmic microtubule
.nucleus
7 EBI-1170906,EBI-524753 ZDHHC17  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.lipoprotein transport
.protein palmitoylation
  + 2 more...
.identical protein binding
.protein-cysteine S-palmitoyltransferase activity
.palmitoyltransferase activity
  + 3 more...
.intracellular membrane-bounded organelle
.Golgi-associated vesicle membrane
.integral component of membrane
  + 3 more...
8 EBI-1170906,EBI-371922 EXOSC8  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.rRNA processing
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.AU-rich element binding .cytosol
.cytoplasm
.nucleolus
  + 2 more...
9 EBI-1170906,EBI-2624951 CITED1  
  .response to transforming growth factor beta
.response to parathyroid hormone
.response to interleukin-11
  + 38 more...
.co-SMAD binding
.LBD domain binding
.transcription regulatory region DNA binding
  + 5 more...
.cytosol
.cytoplasm
.nucleus
10 EBI-1170906,EBI-1769146 VRK1  
  .Golgi disassembly
.histone H3-T3 phosphorylation
.cell division
  + 10 more...
.histone kinase activity (H3-T3 specific)
.histone kinase activity (H3-S10 specific)
.nucleosomal histone binding
  + 4 more...
.cytosol
.spindle
.Golgi stack
  + 4 more...
11 EBI-1170906,EBI-2125614 KIFC3  
  .epithelial cell-cell adhesion
.zonula adherens maintenance
.metabolic process
  + 3 more...
.ATPase activity
.ATP binding
.microtubule motor activity
.extracellular exosome
.cytoplasmic vesicle membrane
.zonula adherens
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
ascites25
bladder33
blood16
bone41
bone marrow20
brain43
cervix41
connective tissue33
embryonic tissue46
eye33
heart11
intestine30
kidney23
liver24
lung32
lymph node55
mammary gland72
mouth30
muscle37
nerve128
ovary19
pancreas42
parathyroid48
pharynx24
placenta31
prostate21
skin23
spleen56
stomach20
testis66
thymus12
thyroid42
trachea154
umbilical cord72
uterus56
vascular38
Health State
TissuesTPM*
normal43
breast (mammary gland) tumor53
cervical tumor57
chondrosarcoma48
colorectal tumor26
gastrointestinal tumor16
germ cell tumor53
glioma27
head and neck tumor29
kidney tumor14
leukemia21
liver tumor52
lung tumor29
lymphoma13
non-neoplasia51
ovarian tumor26
pancreatic tumor9
primitive neuroectodermal tumor of the CNS23
prostate cancer9
skin tumor39
soft tissue/muscle tissue tumor23
uterine tumor88
Developmental Stage
TissuesTPM*
adult35
embryoid body85
blastocyst48
neonate32
fetus46
juvenile71
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue16.5
adrenal gland22.8
appendix19.6
bone marrow18.9
cerebral cortex26.3
colon16.6
duodenum14.9
esophagus16.1
gallbladder22.9
heart muscle11
kidney19.1
liver14.8
lung16.2
lymph node21.7
ovary29
pancreas10.6
placenta18.6
prostate19
salivary gland14.6
skin9.3
small intestine14.5
spleen18.6
stomach16
testis29
thyroid gland36.8
urinary bladder21.5
Tissues
TissuesExpression level
adrenal glandHigh
appendixLow
bone marrowMedium
breastMedium
bronchusMedium
cerebellumHigh
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1High
endometrium 2Medium
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderLow
heart muscleLow
hippocampusHigh
kidneyMedium
lateral ventricleMedium
liverMedium
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
ovaryMedium
pancreasHigh
parathyroid glandLow
placentaHigh
prostateHigh
rectumMedium
salivary glandMedium
seminal vesicleMedium
skin 1Low
skin 2Medium
small intestineMedium
smooth muscleLow
soft tissue 1Low
soft tissue 2Low
spleenMedium
stomach 1Low
stomach 2Low
testisMedium
thyroid glandHigh
tonsilMedium
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*123811, gene) Activating transcription factor 2; ATF2OMIM


#424, YPRC/BPRC, Industry-University Research Center, Yonsei Univ., Seodaemun-gu, Seoul, Korea, 120-749
Tel: +82-2-2123-6626, Fax: +82-2-393-6589
2014-2019 (C) Yonsei Proteome Research Center