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> Protein (NX_P15428)
Protein (NX_P15428)
Protein
Gene SymbolHPGD to neXtProt (NX_P15428)
Description15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Chromosome4
Location4q34.1 (175411328 ~ 175444305) to Ensembl
Sequene Features : Isoforms 5, Variants 34, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.lipoxin metabolic process
.ductus arteriosus closure
.thrombin receptor signaling pathway
  + 10 more...
.NAD+ binding
.NAD binding
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.basolateral plasma membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
5 34 1
2014-09-19protein level
5 28 1
2014-05-27protein level
5 27 1
2014-02-25protein level
5 27 1
2013-12-09protein level
5 19 1
2013-11-01protein level
5 19 1
2013-09-12protein level
5 19 1
2013-08-17protein level
5 19 1
2013-07-15protein level
5 10 1
2013-06-11protein level
5 10 1
2013-02-12protein level
4 7 0
2012-12-20protein level
2 7 0
2012-10-30protein level
2 9 0
2012-10-07protein level
2 9 0
2012-08-24protein level
2 9 0
2012-07-28protein level
2 9 0
2012-06-08protein level
2 13 0
2012-05-07protein level
2 13 0
2012-04-10protein level
2 13 0
2012-01-13protein level
1 9 0
2011-12-20protein level
1 9 0
2011-11-11protein level
1 9 0
2011-08-23protein level
1 9 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P15428-1
0 14 0 28958.7663
NX_P15428-2
1 9 0 19271.7827
NX_P15428-3
0 7 0 15685.8717
NX_P15428-4
1 7 0 15523.9719
NX_P15428-5
1 11 0 21511.9743
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland30
bladder803
bone marrow41
brain6
cervix20
connective tissue20
ear124
embryonic tissue23
esophagus49
eye9
heart11
intestine150
kidney99
liver68
lung83
mammary gland13
mouth60
muscle28
pancreas14
pharynx24
placenta696
prostate52
skin23
spleen56
stomach135
testis2
uterus254
Health State
TissuesTPM*
normal100
bladder carcinoma739
breast (mammary gland) tumor21
colorectal tumor71
gastrointestinal tumor59
germ cell tumor15
head and neck tumor22
leukemia31
liver tumor41
lung tumor9
pancreatic tumor28
prostate cancer28
skin tumor23
soft tissue/muscle tissue tumor23
uterine tumor33
Developmental Stage
TissuesTPM*
adult123
blastocyst32
fetus21
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.6
adrenal gland19.2
appendix17.9
bone marrow2.6
colon84.6
duodenum180.8
esophagus114.1
gallbladder36.7
heart muscle1.6
kidney57.5
liver113.8
lung109.8
lymph node5.8
ovary1.1
pancreas1.5
placenta189.3
prostate9.2
salivary gland4
skin37
small intestine142.2
spleen13.3
stomach245.4
testis2.4
thyroid gland2.4
urinary bladder519.1
Tissues
TissuesExpression level
adrenal glandLow
appendixMedium
bone marrowLow
bronchusLow
cervix, uterineLow
colonMedium
duodenumHigh
endometrium 1Low
endometrium 2Low
epididymisMedium
fallopian tubeLow
gallbladderMedium
heart muscleMedium
kidneyLow
liverLow
lungMedium
lymph nodeLow
ovaryLow
pancreasLow
placentaLow
rectumMedium
skeletal muscleLow
skin 1Medium
small intestineMedium
spleenLow
stomach 1High
stomach 2High
testisLow
thyroid glandLow
tonsilLow
urinary bladderHigh
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(#119900, phenotype) Digital clubbing, isolated congenitalOMIM
2(#259100, phenotype) Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; PHOAR1OMIM
3(*601688, gene) 15-@hydroxyprostaglandin dehydrogenase; HPGDOMIM


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