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> Protein (NX_P15498)
Protein (NX_P15498)
Protein
Gene SymbolVAV1 to neXtProt (NX_P15498)
DescriptionProto-oncogene vav
Chromosome19
Location19p13.3 (6772725 ~ 6857377) to Ensembl
Sequene Features : Isoforms 2, Variants 138, PTMs 12 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.apoptotic signaling pathway
.reactive oxygen species metabolic process
.regulation of small GTPase mediated signal transduction
  + 19 more...
.metal ion binding
.Rac guanyl-nucleotide exchange factor activity
.guanyl-nucleotide exchange factor activity
.sequence-specific DNA binding transcription factor activity
.cell-cell junction
.plasma membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 138 12
2014-09-19protein level
2 97 12
2014-05-27protein level
2 97 12
2014-02-25protein level
2 95 12
2013-12-09protein level
2 87 12
2013-11-01protein level
2 79 12
2013-09-12protein level
2 79 12
2013-08-17protein level
2 79 12
2013-07-15protein level
1 51 2
2013-06-11protein level
1 51 2
2013-02-12protein level
1 26 5
2012-12-20protein level
1 26 5
2012-10-30protein level
1 29 5
2012-10-07protein level
1 29 5
2012-08-24protein level
1 26 5
2012-07-28protein level
1 26 5
2012-06-08protein level
1 31 5
2012-05-07protein level
1 11 5
2012-04-10protein level
1 11 5
2012-01-13protein level
1 10 5
2011-12-20protein level
1 9 5
2011-11-11protein level
1 9 5
2011-08-23protein level
1 9 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P15498-1
3 33 1 98250.8631
NX_P15498-2
1 33 1 94432.1
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-625518,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
2 EBI-625518,EBI-401755 GRB2  
  .positive regulation of reactive oxygen species metabolic process
.cellular response to ionizing radiation
.branching involved in labyrinthine layer morphogenesis
  + 25 more...
.ephrin receptor binding
.poly(A) RNA binding
.insulin receptor substrate binding
  + 6 more...
.Grb2-EGFR complex
.extracellular exosome
.vesicle membrane
  + 10 more...
3 EBI-625518,EBI-413628 RAC1  
  .positive regulation of substrate adhesion-dependent cell spreading
.apoptotic signaling pathway
.ruffle assembly
  + 63 more...
.Rho GDP-dissociation inhibitor binding
.thioesterase binding
.enzyme binding
  + 2 more...
.extracellular exosome
.melanosome
.cytoplasmic ribonucleoprotein granule
  + 12 more...
4 EBI-625518,EBI-727062 SH3BP2  
  .positive regulation of signal transduction
.signal transduction
.SH3/SH2 adaptor activity .N/A
5 EBI-625518,EBI-1364 KHDRBS1  
  .positive regulation of RNA export from nucleus
.regulation of RNA export from nucleus
.positive regulation of translational initiation
  + 8 more...
.poly(A) RNA binding
.identical protein binding
.poly(U) RNA binding
  + 4 more...
.Grb2-Sos complex
.membrane
.cytoplasm
  + 2 more...
6 EBI-625518,EBI-346946 LCP2  
  .T cell receptor signaling pathway
.cytokine secretion
.positive regulation of protein kinase activity
  + 8 more...
.N/A .cell-cell junction
.cytosol
7 EBI-625518,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
8 EBI-625518,EBI-375446 ABI1  
  .lamellipodium morphogenesis
.vascular endothelial growth factor receptor signaling pathway
.innate immune response
  + 10 more...
.protein complex binding
.protein tyrosine kinase activator activity
.cytoskeletal protein binding
.extracellular exosome
.postsynaptic membrane
.SCAR complex
  + 10 more...
9 EBI-625518,EBI-625509 ZNF655  
  .negative regulation of G1/S transition of mitotic cell cycle
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.cytoplasm
.nucleolus
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites25
blood89
bone13
bone marrow20
brain7
connective tissue13
embryonic tissue4
eye4
lung20
lymph22
lymph node55
mouth15
ovary29
pancreas28
pharynx24
placenta10
prostate15
spleen149
testis22
thymus238
trachea19
uterus8
Health State
TissuesTPM*
normal9
gastrointestinal tumor8
germ cell tumor11
head and neck tumor14
leukemia95
lung tumor29
lymphoma41
non-neoplasia31
ovarian tumor26
pancreatic tumor57
prostate cancer28
uterine tumor22
Developmental Stage
TissuesTPM*
adult11
blastocyst16
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue6.5
adrenal gland3.9
appendix39.5
bone marrow41.8
cerebral cortex3.4
colon6.8
duodenum5.7
esophagus3.9
gallbladder7.7
heart muscle1.5
kidney1.5
liver2.5
lung11.3
lymph node48.5
ovary1.3
placenta7.9
prostate3
salivary gland4.8
skin1.5
small intestine7.2
spleen38.1
stomach7
testis2.8
thyroid gland1.5
urinary bladder14.7
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*164875, gene) Vav1 oncogene; VAV1OMIM


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