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> Protein (NX_P15514)
Protein (NX_P15514)
Protein
Gene SymbolAREG to neXtProt (NX_P15514)
DescriptionAmphiregulin
Chromosome4
Location4q13.3 (75310851 ~ 75320726) to Ensembl
Sequene Features : Isoforms 1, Variants 3, PTMs 10 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.epithelial cell proliferation involved in mammary gland duct elongation
.mammary gland alveolus development
.mammary gland branching involved in thelarche
  + 16 more...
.growth factor activity
.epidermal growth factor receptor binding
.integral component of membrane
.cell surface
.cytoplasm
  + 2 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 3 10
2014-09-19protein level
1 10 10
2014-05-27protein level
1 10 10
2014-02-25protein level
1 9 10
2013-12-09protein level
1 9 10
2013-11-01protein level
1 9 10
2013-09-12protein level
1 9 10
2013-08-17protein level
1 9 10
2013-07-15protein level
1 6 6
2013-06-11protein level
1 6 6
2013-02-12protein level
1 2 6
2012-12-20protein level
1 2 6
2012-10-30protein level
1 3 6
2012-10-07protein level
1 3 6
2012-08-24protein level
1 3 6
2012-07-28protein level
1 4 6
2012-06-08protein level
1 3 6
2012-05-07protein level
1 3 6
2012-04-10protein level
1 4 6
2012-01-13protein level
1 3 6
2011-12-20protein level
1 3 6
2011-11-11protein level
1 3 6
2011-08-23protein level
1 4 6
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P15514-1
12 0 0 27877.7325
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-953674,EBI-717058 S100A4  
  .positive regulation of I-kappaB kinase/NF-kappaB signaling
.epithelial to mesenchymal transition
.RAGE receptor binding
.poly(A) RNA binding
.calcium ion binding
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood8
bone marrow20
cervix20
esophagus148
intestine30
kidney4
liver14
lung23
lymph node22
mammary gland13
muscle9
placenta3
prostate10
skin14
stomach114
testis2
trachea19
uterus4
vascular38
Health State
TissuesTPM*
normal1
breast (mammary gland) tumor21
cervical tumor28
colorectal tumor26
esophageal tumor173
gastrointestinal tumor84
kidney tumor14
leukemia10
liver tumor20
lung tumor9
prostate cancer9
Developmental Stage
TissuesTPM*
adult2
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue8.8
adrenal gland2.9
appendix23.5
bone marrow43.9
colon14.2
duodenum1.4
esophagus15.9
gallbladder45.8
heart muscle1.4
liver1
lung10
lymph node1.3
ovary1
placenta182.2
skin1.3
small intestine5.1
spleen2.7
stomach11.9
testis4.2
thyroid gland3.9
urinary bladder21.9
Cancer
TumorNumber of patients and Staining levels
breast cancer
breast cancer
carcinoid
carcinoid
cervical cancer
cervical cancer
colorectal cancer
colorectal cancer
endometrial cancer
endometrial cancer
glioma
glioma
head and neck cancer
head and neck cancer
liver cancer
liver cancer
lung cancer
lung cancer
lymphoma
lymphoma
melanoma
melanoma
ovarian cancer
ovarian cancer
pancreatic cancer
pancreatic cancer
prostate cancer
prostate cancer
renal cancer
renal cancer
skin cancer
skin cancer
stomach cancer
stomach cancer
testis cancer
testis cancer
thyroid cancer
thyroid cancer
urothelial cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*104640, gene) Amphiregulin; AREGOMIM


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