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> Protein (NX_P15531)
Protein (NX_P15531)
Protein
Gene SymbolNME1 to neXtProt (NX_P15531)
DescriptionNucleoside diphosphate kinase A
Chromosome17
Location17q21.33 (49230897 ~ 49239789) to Ensembl
Sequene Features : Isoforms 2, Variants 16, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.cellular response to fatty acid
.cellular response to glucose stimulus
.nucleobase-containing small molecule metabolic process
  + 22 more...
.poly(A) RNA binding
.ribosomal small subunit binding
.identical protein binding
  + 7 more...
.extracellular exosome
.perinuclear region of cytoplasm
.ruffle membrane
  + 7 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 16 5
2014-09-19protein level
2 15 5
2014-05-27protein level
2 15 12
2014-02-25protein level
2 15 12
2013-12-09protein level
2 8 12
2013-11-01protein level
2 8 8
2013-09-12protein level
2 8 8
2013-08-17protein level
2 8 8
2013-07-15protein level
2 6 7
2013-06-11protein level
2 6 7
2013-02-12protein level
2 2 14
2012-12-20protein level
2 3 14
2012-10-30protein level
2 5 14
2012-10-07protein level
2 5 7
2012-08-24protein level
2 5 7
2012-07-28protein level
2 5 7
2012-06-08protein level
2 10 7
2012-05-07protein level
2 10 7
2012-04-10protein level
2 10 7
2012-01-13protein level
2 9 7
2011-12-20protein level
2 9 7
2011-11-11protein level
2 9 7
2011-08-23protein level
2 9 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P15531-1
0 2 7 17137.6229
NX_P15531-2
1 2 7 19640.8499
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-741141,EBI-744871 NME4  
  .nucleobase-containing small molecule metabolic process
.small molecule metabolic process
.regulation of apoptotic process
  + 9 more...
.metal ion binding
.lipid binding
.ATP binding
.nucleoside diphosphate kinase activity
.cytosol
.mitochondrial matrix
.mitochondrial intermembrane space
  + 2 more...
2 EBI-741141,EBI-431907 TNPO2  
  .intracellular protein transport .nuclear localization sequence binding .cytoplasm
.nucleus
3 EBI-741141,EBI-1055079 POLR1C  
  .negative regulation of gene expression, epigenetic
.innate immune response
.regulation of gene expression, epigenetic
  + 9 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
.nucleoplasm
4 EBI-741141,EBI-1914514 MCF2  
  .apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.neurotrophin TRK receptor signaling pathway
  + 3 more...
.Rho guanyl-nucleotide exchange factor activity .extracellular exosome
.membrane
.cytoskeleton
.cytosol
5 EBI-741141,EBI-713693 NME2  
  .activation of mitophagy in response to mitochondrial depolarization
.nucleobase-containing small molecule metabolic process
.positive regulation of epithelial cell proliferation
  + 16 more...
.metal ion binding
.ATP binding
.protein histidine kinase activity
  + 3 more...
.cell periphery
.extracellular exosome
.lamellipodium
  + 5 more...
6 EBI-741141,EBI-713684 NME3  
  .regulation of apoptotic process
.nucleoside triphosphate biosynthetic process
.apoptotic process
  + 5 more...
.metal ion binding
.ATP binding
.nucleoside diphosphate kinase activity
.extracellular exosome
.cytosol
.mitochondrion
7 EBI-741141,EBI-10256685 PID1  
  .negative regulation of glucose import in response to insulin stimulus
.positive regulation of ATP biosynthetic process
.negative regulation of ATP biosynthetic process
  + 19 more...
.N/A .cytoplasm
.nucleoplasm
8 EBI-741141,EBI-2127112 PRUNE  
  .polyphosphate catabolic process .metal ion binding
.inorganic diphosphatase activity
.exopolyphosphatase activity
.focal adhesion
.cytoplasm
.nucleus
9 EBI-741141,EBI-10268630 SREK1IP1  
  .RNA splicing
.mRNA processing
.zinc ion binding
.nucleic acid binding
.N/A
10 EBI-741141,EBI-741158 WDYHV1  
  .cellular protein modification process .protein-N-terminal glutamine amidohydrolase activity .cytosol
.nucleus
11 EBI-741141,EBI-727414 STRAP  
  .negative regulation of pathway-restricted SMAD protein phosphorylation
.negative regulation of epithelial cell proliferation
.negative regulation of transforming growth factor beta receptor signaling pathway
  + 6 more...
.poly(A) RNA binding .SMN-Sm protein complex
.SMN complex
.plasma membrane
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland333
ascites451
bladder234
blood319
bone363
bone marrow123
brain126
cervix164
connective tissue234
ear62
embryonic tissue366
esophagus198
eye411
heart245
intestine262
kidney208
larynx170
liver467
lung310
lymph541
lymph node133
mammary gland416
mouth75
muscle141
nerve193
ovary285
pancreas281
parathyroid291
pharynx441
pituitary gland363
placenta158
prostate274
salivary gland444
skin574
stomach271
testis119
thymus25
thyroid85
tonsil117
umbilical cord508
uterus215
vascular174
Health State
TissuesTPM*
normal186
adrenal tumor632
bladder carcinoma113
breast (mammary gland) tumor537
cervical tumor144
chondrosarcoma169
colorectal tumor302
esophageal tumor231
gastrointestinal tumor312
germ cell tumor208
glioma93
head and neck tumor179
kidney tumor261
leukemia317
liver tumor374
lung tumor535
lymphoma443
non-neoplasia31
ovarian tumor288
pancreatic tumor352
primitive neuroectodermal tumor of the CNS283
prostate cancer471
retinoblastoma990
skin tumor813
soft tissue/muscle tissue tumor367
uterine tumor177
Developmental Stage
TissuesTPM*
adult236
embryoid body528
blastocyst195
neonate225
fetus156
infant170
juvenile161
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue40.4
adrenal gland52.2
appendix63.1
bone marrow41.4
cerebral cortex50.5
colon54.4
duodenum28.1
esophagus52.6
gallbladder19.5
heart muscle18.3
kidney29.3
liver36.5
lung20.4
lymph node61.7
ovary19.5
pancreas21.5
placenta34.7
prostate29.2
salivary gland32.2
skin38
small intestine23.5
spleen20.8
stomach29.4
testis24.4
thyroid gland38.8
urinary bladder51.5
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
bone marrowMedium
breastHigh
bronchusMedium
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeMedium
gallbladderMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
liverLow
lungLow
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryLow
pancreasMedium
parathyroid glandMedium
placentaMedium
prostateMedium
rectumHigh
salivary glandMedium
seminal vesicleMedium
skin 1Medium
skin 2Medium
small intestineMedium
soft tissue 1Low
soft tissue 2Medium
spleenMedium
stomach 1High
stomach 2Medium
testisMedium
thyroid glandMedium
tonsilMedium
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*156490, gene) Nonmetastatic cells 1, protein expressed in; NME1OMIM


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