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> Protein (NX_P15622)
Protein (NX_P15622)
Protein
Gene SymbolZNF250 to neXtProt (NX_P15622)
DescriptionZinc finger protein 250
Chromosome8
Location8q24.3 (146076632 ~ 146127553) to Ensembl
Sequene Features : Isoforms 3, Variants 49, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 49 0
2014-09-19protein level
3 36 0
2014-05-27protein level
3 36 1
2014-02-25protein level
3 36 1
2013-12-09protein level
3 26 1
2013-11-01protein level
3 25 1
2013-09-12protein level
3 25 1
2013-08-17protein level
3 25 1
2013-07-15protein level
3 14 0
2013-06-11protein level
3 14 0
2013-02-12protein level
3 5 0
2012-12-20protein level
3 6 0
2012-10-30protein level
2 8 0
2012-10-07protein level
2 8 0
2012-08-24transcript level
2 7 0
2012-07-28transcript level
2 6 0
2012-06-08transcript level
2 8 0
2012-05-07transcript level
2 8 0
2012-04-10transcript level
2 8 0
2012-01-13transcript level
2 5 0
2011-12-20transcript level
2 5 0
2011-11-11transcript level
2 5 0
2011-08-23transcript level
2 5 0
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P15622-1
1 29 2 63426.8892
NX_P15622-2
0 24 2 49989.5826
NX_P15622-3
0 30 2 62854.5949
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-10177272,EBI-743871 TFF1  
  .response to peptide hormone
.response to immobilization stress
.response to estradiol
  + 6 more...
.N/A .extracellular space
2 EBI-10177272,EBI-719493 TRIM27  
  .negative regulation of viral release from host cell
.negative regulation of interleukin-2 secretion
.negative regulation of calcium ion import
  + 17 more...
.metal ion binding
.ligase activity
.zinc ion binding
  + 4 more...
.nuclear membrane
.PML body
.membrane
  + 6 more...
3 EBI-10177272,EBI-10172290 KRTAP10-7  
  .N/A .identical protein binding .keratin filament
4 EBI-10177272,EBI-618309 GOLGA2  
  .negative regulation of protein binding
.mitotic cell cycle
.syntaxin binding
.protein kinase binding
.Golgi cisterna membrane
.ER to Golgi transport vesicle
.cis-Golgi network
  + 4 more...
5 EBI-10177272,EBI-2555738 ZNF460  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
6 EBI-10177272,EBI-1104907 GNPTAB  
  .carbohydrate phosphorylation
.cell differentiation
.N-glycan processing to lysosome
  + 2 more...
.calcium ion binding
.UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
.integral component of membrane
.Golgi apparatus
.nucleus
.Golgi membrane
7 EBI-10177272,EBI-742948 MTUS2  
  .N/A .protein homodimerization activity
.microtubule binding
.microtubule
.cytoplasm
.nucleus
8 EBI-10177272,EBI-949753 TENC1  
  .multicellular organismal homeostasis
.intracellular signal transduction
.multicellular organism growth
  + 5 more...
.metal ion binding
.kinase binding
.phosphoprotein phosphatase activity
.focal adhesion
.plasma membrane
9 EBI-10177272,EBI-10171697 KRT40  
  .N/A .structural molecule activity .intermediate filament
10 EBI-10177272,EBI-744506 FAM124A  
  .N/A .N/A .N/A
11 EBI-10177272,EBI-7131783 SYNE4  
  .establishment of epithelial cell apical/basal polarity .N/A .LINC complex
.integral component of nuclear outer membrane
12 EBI-10177272,EBI-749265 CCDC155  
  .chromosome localization to nuclear envelope involved in homologous chromosome segregation
.oogenesis
.spermatogenesis
  + 2 more...
.N/A .integral component of membrane
.nuclear outer membrane
.lateral element
.chromosome, telomeric region
13 EBI-10177272,EBI-751409 ZNF473  
  .mRNA 3'-end processing
.gene expression
.histone mRNA metabolic process
  + 4 more...
.metal ion binding
.DNA binding
.Cajal body
.nucleoplasm
14 EBI-10177272,EBI-725997 TRIM41  
  .protein ubiquitination .ligase activity
.zinc ion binding
.cytoplasm
.nucleolus
15 EBI-10177272,EBI-746778 MAGOHB  
  .mRNA transport
.RNA splicing
.mRNA processing
.poly(A) RNA binding .catalytic step 2 spliceosome
.exon-exon junction complex
16 EBI-10177272,EBI-5278764 CDCA7L  
  .positive regulation of cell proliferation
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.N/A .cytoplasm
.nucleolus
.nucleus
17 EBI-10177272,EBI-10171416 CCDC136  
  .N/A .N/A .integral component of membrane
.mitochondrion
18 EBI-10177272,EBI-741037 LZTS2  
  .negative regulation of protein localization to nucleus
.negative regulation of canonical Wnt signaling pathway
.spindle midzone assembly
  + 7 more...
.N/A .midbody
.microtubule
.centrosome
.cytoplasm
19 EBI-10177272,EBI-2130429 TRIM54  
  .cell differentiation
.multicellular organismal development
.signal transduction
  + 2 more...
.zinc ion binding
.signal transducer activity
.Z disc
.microtubule associated complex
.microtubule
20 EBI-10177272,EBI-751319 CARD9  
  .nucleotide-binding oligomerization domain containing signaling pathway
.defense response to virus
.defense response to Gram-positive bacterium
  + 17 more...
.CARD domain binding
.protein homodimerization activity
.plasma membrane
.cytosol
.cytoplasm
21 EBI-10177272,EBI-742388 PLEKHF2  
  .protein transport .metal ion binding .early endosome membrane
.transport vesicle
.endoplasmic reticulum
22 EBI-10177272,EBI-747993 ZC4H2  
  .spinal cord motor neuron differentiation
.neuromuscular junction development
.nervous system development
.metal ion binding .postsynaptic membrane
.cell junction
.cytoplasm
.nucleus
23 EBI-10177272,EBI-10172526 MID2  
  .negative regulation of viral release from host cell
.positive regulation of NF-kappaB transcription factor activity
.positive regulation of sequence-specific DNA binding transcription factor activity
  + 6 more...
.phosphoprotein binding
.protein heterodimerization activity
.protein homodimerization activity
  + 3 more...
.extracellular exosome
.microtubule
.cytoplasm
24 EBI-10177272,EBI-2212028 SSX2IP  
  .regulation of cell motility
.centrosome organization
.cilium assembly
  + 3 more...
.N/A .protein complex
.ciliary basal body
.centriolar satellite
  + 3 more...
25 EBI-10177272,EBI-3438881 ZNF175  
  .defense response to virus
.regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.intermediate filament cytoskeleton
.cytoplasm
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
blood16
bone27
brain19
eye23
heart44
intestine12
kidney14
lung17
lymph node11
mouth15
muscle9
ovary39
pancreas23
pituitary gland60
placenta3
spleen18
stomach10
testis9
thymus25
trachea19
uterus12
vascular38
Health State
TissuesTPM*
normal16
chondrosarcoma24
colorectal tumor8
gastrointestinal tumor8
germ cell tumor3
glioma9
head and neck tumor7
kidney tumor14
non-neoplasia10
ovarian tumor52
pancreatic tumor9
soft tissue/muscle tissue tumor15
Developmental Stage
TissuesTPM*
adult10
fetus28
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue3.3
adrenal gland4.1
appendix3.5
bone marrow1.4
cerebral cortex5
colon4
duodenum4.6
esophagus4.4
gallbladder4.5
heart muscle3.5
kidney6.1
liver2.2
lung5
lymph node3.9
ovary10.6
pancreas2.6
placenta4.3
prostate5.6
salivary gland3.7
skin7
small intestine4.4
spleen5.3
stomach3.7
testis5
thyroid gland12.1
urinary bladder5.2
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected


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2014-2019 (C) Yonsei Proteome Research Center