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> Protein (NX_P15882)
Protein (NX_P15882)
Protein
Gene SymbolCHN1 to neXtProt (NX_P15882)
DescriptionN-chimaerin
Chromosome2
Location2q31.1 (175664091 ~ 175870097) to Ensembl
Sequene Features : Isoforms 3, Variants 75, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.regulation of small GTPase mediated signal transduction
.regulation of axonogenesis
.ephrin receptor signaling pathway
  + 3 more...
.metal ion binding
.GTPase activator activity
.SH3/SH2 adaptor activity
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
3 75 2
2014-09-19protein level
3 55 2
2014-05-27protein level
3 55 2
2014-02-25protein level
3 55 2
2013-12-09protein level
3 45 2
2013-11-01protein level
3 44 2
2013-09-12protein level
3 44 2
2013-08-17protein level
3 44 2
2013-07-15protein level
3 28 0
2013-06-11protein level
3 28 0
2013-02-12protein level
3 11 2
2012-12-20protein level
3 15 2
2012-10-30protein level
3 16 2
2012-10-07protein level
3 16 1
2012-08-24protein level
3 12 1
2012-07-28protein level
3 12 1
2012-06-08protein level
3 12 1
2012-05-07protein level
3 12 1
2012-04-10protein level
2 12 1
2012-01-13protein level
2 9 1
2011-12-20protein level
2 9 1
2011-11-11protein level
2 9 1
2011-08-23protein level
2 9 1
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P15882-1
0 22 1 53137.808
NX_P15882-2
3 14 0 38171.5417
NX_P15882-3
0 22 1 50001.0665
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-718947,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
2 EBI-718947,EBI-10329202 HEMK1  
  .DNA methylation .protein methyltransferase activity
.N-methyltransferase activity
.DNA binding
.mitochondrion
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adrenal gland60
blood16
bone83
brain957
connective tissue46
embryonic tissue56
esophagus49
eye52
heart22
intestine21
kidney246
liver34
lung56
lymph node55
muscle47
nerve64
ovary29
pancreas28
pharynx270
pituitary gland242
placenta56
prostate10
salivary gland197
skin99
spleen37
stomach10
testis50
thyroid21
trachea38
uterus34
Health State
TissuesTPM*
normal282
adrenal tumor158
chondrosarcoma48
colorectal tumor8
esophageal tumor57
gastrointestinal tumor8
germ cell tumor60
glioma65
head and neck tumor104
kidney tumor696
liver tumor41
lung tumor29
lymphoma69
non-neoplasia900
ovarian tumor39
pancreatic tumor9
primitive neuroectodermal tumor of the CNS86
prostate cancer9
retinoblastoma21
skin tumor7
soft tissue/muscle tissue tumor71
uterine tumor44
Developmental Stage
TissuesTPM*
adult103
embryoid body85
blastocyst65
neonate193
fetus57
infant85
juvenile53
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue10.4
adrenal gland17.3
appendix12.3
cerebral cortex334.7
colon5.9
duodenum4.3
esophagus12.1
gallbladder14.9
heart muscle14.7
kidney4
liver1.7
lung23.4
lymph node24.5
ovary8.7
pancreas2.7
placenta32.7
prostate16.6
salivary gland3.6
skin4.6
small intestine5.4
spleen7
stomach4.4
testis31.8
thyroid gland15
urinary bladder17.5
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Disease
No.Disease DescriptionRef.
1(*118423, gene) Chimerin 1; CHN1OMIM
2(#604356, phenotype) Duane retraction syndrome 2; DURS2OMIM
3extraskeletal myxoid chondrosarcomaCGP


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