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> Protein (NX_P15884)
Protein (NX_P15884)
Protein
Gene SymbolTCF4 to neXtProt (NX_P15884)
DescriptionTranscription factor 4
Chromosome18
Location18q21.2 (52889562 ~ 53332018) to Ensembl
Sequene Features : Isoforms 16, Variants 118, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein-DNA complex assembly
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
  + 3 more...
.E-box binding
.protein heterodimerization activity
.bHLH transcription factor binding
  + 9 more...
.transcription factor complex
.nucleus
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
16 118 3
2014-09-19protein level
16 86 3
2014-05-27protein level
16 86 3
2014-02-25protein level
14 83 3
2013-12-09protein level
14 78 3
2013-11-01protein level
14 68 3
2013-09-12protein level
14 68 3
2013-08-17protein level
13 68 3
2013-07-15protein level
11 50 3
2013-06-11protein level
11 50 3
2013-02-12protein level
11 28 22
2012-12-20protein level
8 29 16
2012-10-30protein level
8 32 16
2012-10-07protein level
8 32 2
2012-08-24protein level
3 20 2
2012-07-28protein level
3 20 2
2012-06-08protein level
3 24 2
2012-05-07protein level
3 24 2
2012-04-10protein level
3 24 2
2012-01-13protein level
3 19 2
2011-12-20protein level
3 17 2
2011-11-11protein level
3 17 2
2011-08-23protein level
3 17 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P15884-1
0 23 2 71263.8913
NX_P15884-10
0 20 2 66985.7931
NX_P15884-11
0 19 2 64562.2003
NX_P15884-12
3 20 2 71183.0077
NX_P15884-13
0 22 2 69054.8788
NX_P15884-14
0 22 2 68568.6142
NX_P15884-15
0 20 2 62060.3739
NX_P15884-16
1 12 2 48068.0685
NX_P15884-2
0 15 2 54586.9959
NX_P15884-3
0 23 2 71750.1559
NX_P15884-4
0 21 2 65241.9156
NX_P15884-5
0 21 2 64755.651
NX_P15884-6
0 15 2 54100.7313
NX_P15884-7
0 19 2 64075.9357
NX_P15884-8
2 15 2 60642.9983
NX_P15884-9
1 15 2 57389.5625
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-533224,EBI-2339359 HAT1  
  .histone H4 acetylation
.response to nutrient
.internal protein amino acid acetylation
  + 5 more...
.H4 histone acetyltransferase activity
.histone acetyltransferase activity
.protein complex
.intracellular membrane-bounded organelle
.nuclear matrix
  + 4 more...
2 EBI-533224,EBI-1055079 POLR1C  
  .negative regulation of gene expression, epigenetic
.innate immune response
.regulation of gene expression, epigenetic
  + 9 more...
.DNA-directed RNA polymerase activity
.DNA binding
.cytosol
.DNA-directed RNA polymerase I complex
.DNA-directed RNA polymerase III complex
.nucleoplasm
3 EBI-533224,EBI-10182490 EPHB6  
  .ephrin receptor signaling pathway
.axon guidance
.ATP binding
.ephrin receptor activity
.receptor activity
.integral component of plasma membrane
.plasma membrane
.cytosol
.extracellular region
4 EBI-533224,EBI-6262458 MATN3  
  .extracellular matrix organization
.skeletal system development
.extracellular matrix structural constituent .proteinaceous extracellular matrix
.extracellular region
5 EBI-533224,EBI-725515 FRS3  
  .fibroblast growth factor receptor signaling pathway
.signal transduction
.fibroblast growth factor receptor binding .plasma membrane
6 EBI-533224,EBI-713635 NCK2  
  .negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.ephrin receptor signaling pathway
.vascular endothelial growth factor receptor signaling pathway
  + 16 more...
.receptor signaling complex scaffold activity
.cytoskeletal adaptor activity
.SH3/SH2 adaptor activity
.vesicle membrane
.cytosol
.endoplasmic reticulum
.cytoplasm
7 EBI-533224,EBI-2814604 SIGLEC6  
  .cell-cell signaling
.cell adhesion
.carbohydrate binding .membrane
.integral component of plasma membrane
.extracellular region
8 EBI-533224,EBI-374889 ORC4  
  .DNA replication initiation
.DNA replication
.mitotic cell cycle
.G1/S transition of mitotic cell cycle
.ATP binding
.DNA replication origin binding
.nucleotide binding
.actin cytoskeleton
.cytoplasm
.nucleolus
  + 4 more...
9 EBI-533224,EBI-947402 MAPKBP1  
  .N/A .N/A .N/A
10 EBI-533224,EBI-398610 EIF4E2  
  .cytokine-mediated signaling pathway
.negative regulation of translation
.in utero embryonic development
.poly(A) RNA binding
.ubiquitin protein ligase binding
.translation factor activity, RNA binding
  + 2 more...
.mRNA cap binding complex
.cytosol
11 EBI-533224,EBI-714135 STX11  
  .membrane fusion
.vesicle docking
.natural killer cell degranulation
  + 4 more...
.SNAP receptor activity
.SNARE binding
.SNARE complex
.integral component of membrane
.endomembrane system
  + 3 more...
12 EBI-533224,EBI-749295 STK16  
  .cellular response to transforming growth factor beta stimulus
.protein autophosphorylation
.regulation of signal transduction
.ATP binding
.non-membrane spanning protein tyrosine kinase activity
.protein serine/threonine kinase activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
.perinuclear region of cytoplasm
.membrane
.Golgi-associated vesicle
.cytoplasm
13 EBI-533224,EBI-1050106 BCAS2  
  .gene expression
.RNA splicing
.mRNA splicing, via spliceosome
.RNA splicing, via transesterification reactions
.N/A .cell junction
.nucleolus
.spliceosomal complex
  + 2 more...
14 EBI-533224,EBI-374781 GLRX3  
  .cell redox homeostasis
.negative regulation of cardiac muscle hypertrophy
.regulation of the force of heart contraction
.iron-sulfur cluster binding
.metal ion binding
.poly(A) RNA binding
  + 2 more...
.extracellular exosome
.Z disc
.cell cortex
15 EBI-533224,EBI-359472 POLR1A  
  .negative regulation of gene expression, epigenetic
.regulation of gene expression, epigenetic
.gene expression
  + 4 more...
.zinc ion binding
.DNA-directed RNA polymerase activity
.DNA binding
.cytoplasm
.DNA-directed RNA polymerase I complex
.nucleolus
  + 2 more...
16 EBI-533224,EBI-4397076 FAH  
  .small molecule metabolic process
.cellular nitrogen compound metabolic process
.tyrosine catabolic process
  + 2 more...
.metal ion binding
.fumarylacetoacetase activity
.extracellular exosome
.cytosol
17 EBI-533224,EBI-4290814 ATP6V1B2  
  .phagosome maturation
.transmembrane transport
.interaction with host
  + 7 more...
.proton-transporting ATPase activity, rotational mechanism
.hydrogen ion transmembrane transporter activity
.ATP binding
.extracellular exosome
.intracellular membrane-bounded organelle
.melanosome
  + 8 more...
18 EBI-533224,EBI-9641086 FLNA  
  .positive regulation of integrin-mediated signaling pathway
.positive regulation of substrate adhesion-dependent cell spreading
.mitotic spindle assembly
  + 24 more...
.actin filament binding
.Rac GTPase binding
.poly(A) RNA binding
  + 8 more...
.apical dendrite
.extracellular exosome
.perinuclear region of cytoplasm
  + 15 more...
19 EBI-533224,EBI-359352 PSMA1  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 23 more...
.threonine-type endopeptidase activity
.endopeptidase activity
.RNA binding
.extracellular exosome
.proteasome core complex, alpha-subunit complex
.polysome
  + 7 more...
20 EBI-533224,EBI-8639312 LMO1  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription from RNA polymerase II promoter
.zinc ion binding .nucleus
21 EBI-533224,EBI-351257 DDX6  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.cytoplasmic mRNA processing body assembly
.viral RNA genome packaging
  + 4 more...
.poly(A) RNA binding
.protein domain specific binding
.ATP binding
  + 3 more...
.intracellular membrane-bounded organelle
.RISC complex
.membrane
  + 5 more...
22 EBI-533224,EBI-745213 AQP1  
  .cation transmembrane transport
.maintenance of symbiont-containing vacuole by host
.ammonium transmembrane transport
  + 60 more...
.carbon dioxide transmembrane transporter activity
.nitric oxide transmembrane transporter activity
.transmembrane transporter activity
  + 8 more...
.extracellular exosome
.apical part of cell
.axon terminus
  + 12 more...
23 EBI-533224,EBI-750589 PBLD  
  .negative regulation of pathway-restricted SMAD protein phosphorylation
.negative regulation of SMAD protein import into nucleus
.negative regulation of epithelial cell proliferation
  + 5 more...
.isomerase activity .extracellular exosome
.cytoplasm
24 EBI-533224,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
25 EBI-533224,EBI-375077 CDKN1A  
  .positive regulation of reactive oxygen species metabolic process
.regulation of DNA biosynthetic process
.negative regulation of G1/S transition of mitotic cell cycle
  + 44 more...
.metal ion binding
.ubiquitin protein ligase binding
.cyclin-dependent protein kinase activating kinase activity
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.PCNA-p21 complex
.perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
  + 4 more...
26 EBI-533224,EBI-711290 CDKN2C  
  .negative regulation of protein serine/threonine kinase activity
.oligodendrocyte differentiation
.negative regulation of phosphorylation
  + 6 more...
.protein kinase binding
.cyclin-dependent protein serine/threonine kinase inhibitor activity
.cytosol
.cytoplasm
.nucleus
27 EBI-533224,EBI-713992 RABIF  
  .membrane fusion
.positive regulation of GTPase activity
.protein transport
.small GTPase mediated signal transduction
.zinc ion binding
.guanyl-nucleotide exchange factor activity
.N/A
28 EBI-533224,EBI-750494 SMCP  
  .sperm motility
.penetration of zona pellucida
.N/A .mitochondrial membrane
.mitochondrion
.cytoplasm
29 EBI-533224,EBI-10211741 GNG10  
  .cellular response to glucagon stimulus
.small molecule metabolic process
.synaptic transmission
  + 3 more...
.signal transducer activity
.GTPase activity
.extracellular exosome
.plasma membrane
.heterotrimeric G-protein complex
30 EBI-533224,EBI-957042 ASCL1  
  .positive regulation of neural precursor cell proliferation
.cellular response to magnetism
.response to epidermal growth factor
  + 44 more...
.E-box binding
.bHLH transcription factor binding
.sequence-specific DNA binding transcription factor activity
  + 6 more...
.neuronal cell body
.nucleus
31 EBI-533224,EBI-1383852 PRKAA2  
  .regulation of energy homeostasis
.membrane organization
.fatty acid homeostasis
  + 31 more...
.[acetyl-CoA carboxylase] kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
.metal ion binding
  + 7 more...
.AMP-activated protein kinase complex
.cytosol
.cytoplasm
.nucleoplasm
32 EBI-533224,EBI-744104 GEM  
  .metaphase plate congression
.chromosome organization
.metabolic process
  + 5 more...
.GDP binding
.GTP binding
.GTPase activity
.magnesium ion binding
.mitotic spindle
.spindle midzone
.midbody
  + 2 more...
33 EBI-533224,EBI-749995 TCL1A  
  .stem cell maintenance
.multicellular organismal development
.N/A .pronucleus
.cell cortex
.endoplasmic reticulum
34 EBI-533224,EBI-456371 CKS1B  
  .cell division
.cell proliferation
.mitotic cell cycle
  + 2 more...
.cyclin-dependent protein serine/threonine kinase regulator activity .nucleoplasm
35 EBI-533224,EBI-10218584 HAND2  
  .positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis
.positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process
.positive regulation of transcription regulatory region DNA binding
  + 34 more...
.E-box binding
.protein homodimerization activity
.activating transcription factor binding
  + 5 more...
.protein complex
.transcription factor complex
.nuclear chromatin
36 EBI-533224,EBI-2798728 LMO4  
  .regulation of cell activation
.thymus development
.positive regulation of transcription from RNA polymerase II promoter
  + 8 more...
.zinc ion binding
.transcription factor binding
.sequence-specific DNA binding transcription factor activity
.enhancer sequence-specific DNA binding
.transcription factor complex
37 EBI-533224,EBI-1054396 OTUD4  
  .protein K48-linked deubiquitination .poly(A) RNA binding
.ubiquitin-specific protease activity
.N/A
38 EBI-533224,EBI-1387094 ID3  
  .regulation of cell cycle
.negative regulation of transcription, DNA-templated
.negative regulation of osteoblast differentiation
  + 17 more...
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
.microtubule cytoskeleton
.cytoplasm
.nucleoplasm
.nucleus
39 EBI-533224,EBI-10223388 RELA  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of miRNA metabolic process
.negative regulation of NIK/NF-kappaB signaling
  + 64 more...
.repressing transcription factor binding
.NF-kappaB binding
.protein N-terminus binding
  + 20 more...
.NF-kappaB complex
.I-kappaB/NF-kappaB complex
.cytosol
  + 4 more...
40 EBI-533224,EBI-717810 AES  
  .positive regulation of anoikis
.negative regulation of canonical Wnt signaling pathway
.response to interleukin-1
  + 12 more...
.transcription corepressor activity .nucleus
41 EBI-533224,EBI-10181260 GOLGA8F  
  .N/A .N/A .Golgi apparatus
42 EBI-533224,EBI-10181276 GOLGA8DP  
  .N/A .N/A .Golgi apparatus
43 EBI-533224,EBI-1020839 CHAF1A  
  .chromatin assembly
.cell cycle
.protein complex assembly
  + 3 more...
.chromo shadow domain binding
.unfolded protein binding
.identical protein binding
.chromatin binding
.protein complex
.CAF-1 complex
.nuclear chromatin
44 EBI-533224,EBI-714158 PIN1  
  .negative regulation of cell motility
.negative regulation of ERK1 and ERK2 cascade
.regulation of pathway-restricted SMAD protein phosphorylation
  + 11 more...
.phosphothreonine binding
.phosphoserine binding
.GTPase activating protein binding
  + 2 more...
.midbody
.nuclear speck
.cytoplasm
  + 2 more...
45 EBI-533224,EBI-74090 EIF4EBP1  
  .negative regulation of translational initiation
.positive regulation of mitotic cell cycle
.response to ethanol
  + 11 more...
.translation repressor activity
.eukaryotic initiation factor 4E binding
.protein complex
.cytosol
.cytoplasm
.nucleoplasm
46 EBI-533224,EBI-742828 LASP1  
  .positive regulation of signal transduction
.ion transport
.ion transmembrane transporter activity
.zinc ion binding
.SH3/SH2 adaptor activity
.extracellular exosome
.cortical actin cytoskeleton
.focal adhesion
47 EBI-533224,EBI-710310 TCEA2  
  .positive regulation of transcription from RNA polymerase II promoter
.regulation of DNA-templated transcription, elongation
.DNA-templated transcription, elongation
.zinc ion binding
.DNA binding
.transcription elongation factor complex
.centrosome
.nucleoplasm
48 EBI-533224,EBI-2555767 ZNF124  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
49 EBI-533224,EBI-10237959 TAL2  
  .multicellular organism growth
.midbrain development
.thalamus development
  + 3 more...
.DNA binding
.sequence-specific DNA binding RNA polymerase II transcription factor activity
.RNA polymerase II regulatory region sequence-specific DNA binding
.nucleus
50 EBI-533224,EBI-10241513 PLEKHN1  
  .N/A .N/A .plasma membrane
51 EBI-533224,EBI-10244509 RAB41  
  .retrograde transport, endosome to Golgi
.Rab protein signal transduction
.metabolic process
  + 3 more...
.GTP binding
.GTPase activity
.Golgi apparatus
52 EBI-533224,EBI-743105 EFHC1  
  .cerebral cortex cell migration .protein C-terminus binding
.calcium ion binding
.mitotic spindle
.neuronal cell body
.axoneme
.centrosome
53 EBI-533224,EBI-1055462 NOL9  
  .maturation of 5.8S rRNA
.cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
.polynucleotide 5'-hydroxyl-kinase activity
.ATP binding
.RNA binding
.membrane
.nucleolus
54 EBI-533224,EBI-10245139 SZT2  
  .regulation of superoxide dismutase activity
.pigmentation
.corpus callosum morphogenesis
  + 2 more...
.N/A .extracellular exosome
.peroxisome
55 EBI-533224,EBI-10247271 FAM74A6  
  .N/A .N/A .N/A
56 EBI-533224,EBI-2557469 PPP1R18  
  .N/A .N/A .cytoskeleton
.cytoplasm
57 EBI-533224,EBI-1643885 KLC3  
  .axon cargo transport .microtubule motor activity .neuron projection
.ciliary rootlet
.motile cilium
  + 3 more...
58 EBI-533224,EBI-10254561 ZDHHC24  
  .N/A .protein-cysteine S-palmitoyltransferase activity
.zinc ion binding
.integral component of membrane
59 EBI-533224,EBI-10254793 ASCL4  
  .skin development
.regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.DNA binding .nucleus
60 EBI-533224,EBI-10255140 C9orf171  
  .N/A .N/A .N/A
61 EBI-533224,EBI-723524 MRPL10  
  .mitochondrial translational termination
.mitochondrial translational elongation
.mitochondrial translational initiation
  + 4 more...
.poly(A) RNA binding
.structural constituent of ribosome
.ribonucleoprotein complex
.mitochondrial large ribosomal subunit
.mitochondrial inner membrane
  + 2 more...
62 EBI-533224,EBI-1752987 NEK8  
  .regulation of hippo signaling
.organ morphogenesis
.microtubule-based process
  + 2 more...
.metal ion binding
.ATP binding
.protein serine/threonine kinase activity
.ciliary base
.ciliary inversin compartment
.primary cilium
  + 3 more...
63 EBI-533224,EBI-10260040 NR2C2AP  
  .gene expression
.transcription initiation from RNA polymerase II promoter
.N/A .extracellular exosome
.nucleoplasm
64 EBI-533224,EBI-10262361 REXO1L1P  
  .N/A .exonuclease activity
.nucleic acid binding
.cytoplasm
.nucleus
65 EBI-533224,EBI-8634060 MSRB3  
  .protein repair
.response to oxidative stress
.peptide-methionine (R)-S-oxide reductase activity
.zinc ion binding
.endoplasmic reticulum
.mitochondrion
66 EBI-533224,EBI-10269566 MORN4  
  .N/A .N/A .N/A
67 EBI-533224,EBI-742815 FLAD1  
  .small molecule metabolic process
.riboflavin metabolic process
.water-soluble vitamin metabolic process
  + 2 more...
.ATP binding
.FMN adenylyltransferase activity
.plasma membrane
.cytosol
.mitochondrial matrix
.cytoplasm
68 EBI-533224,EBI-726826 NUDT10  
  .small molecule metabolic process
.inositol phosphate metabolic process
.inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
.inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity
.inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity
  + 6 more...
.cytosol
69 EBI-533224,EBI-740727 ZNF417  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
70 EBI-533224,EBI-10274069 LGALS14  
  .positive regulation of T cell apoptotic process
.apoptotic process
.carbohydrate binding .nucleus
71 EBI-533224,EBI-1797313 TWIST2  
  .cornea development in camera-type eye
.face morphogenesis
.embryonic cranial skeleton morphogenesis
  + 10 more...
.sequence-specific DNA binding transcription factor activity
.chromatin binding
.DNA binding
.RNA polymerase II transcription factor binding transcription factor activity
.cytoplasm
.transcription factor complex
.nucleus
72 EBI-533224,EBI-10277551 NEU4  
  .small molecule metabolic process
.cellular protein metabolic process
.post-translational protein modification
  + 7 more...
.exo-alpha-(2->8)-sialidase activity
.exo-alpha-(2->6)-sialidase activity
.exo-alpha-(2->3)-sialidase activity
.exo-alpha-sialidase activity
.lysosomal lumen
.organelle inner membrane
.lysosome
.mitochondrion
73 EBI-533224,EBI-10277790 PATE1  
  .N/A .N/A .extracellular region
74 EBI-533224,EBI-707714 BCL2L2  
  .negative regulation of intrinsic apoptotic signaling pathway
.extrinsic apoptotic signaling pathway in absence of ligand
.Sertoli cell proliferation
  + 3 more...
.protein heterodimerization activity
.protein homodimerization activity
.extracellular exosome
.cytosol
.mitochondrial outer membrane
75 EBI-533224,EBI-10279647 NEUROG1  
  .positive regulation of sequence-specific DNA binding transcription factor activity
.positive regulation of transcription from RNA polymerase II promoter
.positive regulation of neuron differentiation
  + 7 more...
.E-box binding
.sequence-specific DNA binding transcription factor activity
.chromatin binding
  + 2 more...
.perikaryon
.nucleus
76 EBI-533224,EBI-465400 ARHGEF1  
  .negative regulation of axonogenesis
.regulation of axonogenesis
.neurotrophin TRK receptor signaling pathway
  + 4 more...
.poly(A) RNA binding
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.plasma membrane
.cytosol
.cytoplasm
77 EBI-533224,EBI-723276 PSMG2  
  .proteasome assembly
.negative regulation of apoptotic process
.mitotic spindle assembly checkpoint
.N/A .nucleus
78 EBI-533224,EBI-746778 MAGOHB  
  .mRNA transport
.RNA splicing
.mRNA processing
.poly(A) RNA binding .catalytic step 2 spliceosome
.exon-exon junction complex
79 EBI-533224,EBI-4399465 FERMT2  
  .protein localization to membrane
.focal adhesion assembly
.substrate adhesion-dependent cell spreading
  + 7 more...
.phosphatidylinositol-3,4,5-trisphosphate binding .filamentous actin
.I band
.lamellipodium membrane
  + 9 more...
80 EBI-533224,EBI-726510 LENG1  
  .N/A .N/A .N/A
81 EBI-533224,EBI-743117 CCDC101  
  .establishment of protein localization to chromatin
.histone H3 acetylation
.regulation of transcription, DNA-templated
  + 2 more...
.methylated histone binding .SAGA-type complex
.Ada2/Gcn5/Ada3 transcription activator complex
82 EBI-533224,EBI-745021 STAMBPL1  
  .N/A .metal ion binding
.metallopeptidase activity
.membrane
83 EBI-533224,EBI-10287091 SLC39A13  
  .zinc II ion transmembrane transport
.connective tissue development
.cellular zinc ion homeostasis
.protein homodimerization activity
.zinc ion transmembrane transporter activity
.perinuclear region of cytoplasm
.integral component of Golgi membrane
.integral component of membrane
.Golgi apparatus
84 EBI-533224,EBI-748896 MRFAP1L1  
  .N/A .identical protein binding .N/A
85 EBI-533224,EBI-8293751 GUCD1  
  .N/A .N/A .N/A
86 EBI-533224,EBI-3918381 TSSK3  
  .intracellular signal transduction
.cell differentiation
.regulation of signal transduction
  + 3 more...
.ATP binding
.protein serine/threonine kinase activity
.magnesium ion binding
.cytoplasm
.nucleus
87 EBI-533224,EBI-10183007 FERD3L  
  .regulation of neurogenesis
.cell development
.negative regulation of transcription, DNA-templated
  + 2 more...
.DNA binding .nucleus
88 EBI-533224,EBI-6427977 ZNF587  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.metal ion binding
.DNA binding
.nucleus
89 EBI-533224,EBI-10189448 KCTD14  
  .protein homooligomerization .N/A .N/A
90 EBI-533224,EBI-5457544 UTP23  
  .maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) .small ribosomal subunit rRNA binding
.poly(A) RNA binding
.small-subunit processome
.nucleolus
91 EBI-533224,EBI-1999704 SLC4A1AP  
  .N/A .N/A .intracellular membrane-bounded organelle
.plasma membrane
.cytoplasm
  + 2 more...
92 EBI-533224,EBI-1993677 ASPSCR1  
  .membrane organization
.regulation of glucose import
.glucose homeostasis
.intracellular protein transport
.N/A .perinuclear region of cytoplasm
.intracellular membrane-bounded organelle
.endoplasmic reticulum-Golgi intermediate compartment membrane
  + 7 more...
93 EBI-533224,EBI-10303844 NMUR2  
  .chloride transmembrane transport
.arachidonic acid secretion
.response to pain
  + 14 more...
.neuromedin U binding
.GTP binding
.intracellular calcium activated chloride channel activity
  + 2 more...
.integral component of membrane
.plasma membrane
94 EBI-533224,EBI-372911 SPATC1L  
  .N/A .N/A .N/A
95 EBI-533224,EBI-745369 DEF6  
  .N/A .N/A .membrane
.cell-cell junction
.plasma membrane
  + 2 more...
96 EBI-533224,EBI-2801103 SMOC1  
  .limb development
.regulation of osteoblast differentiation
.extracellular matrix organization
  + 4 more...
.extracellular matrix binding
.calcium ion binding
.basement membrane
97 EBI-533224,EBI-741626 FAM124B  
  .N/A .N/A .N/A
98 EBI-533224,EBI-742909 ARMC7  
  .N/A .N/A .cytoplasm
.nucleus
99 EBI-533224,EBI-739467 GORASP2  
  .organelle organization
.mitotic cell cycle
.N/A .membrane
.Golgi apparatus
.Golgi membrane
100 EBI-533224,EBI-740364 NEK6  
  .regulation of cellular senescence
.spindle assembly
.protein autophosphorylation
  + 13 more...
.protein kinase binding
.kinesin binding
.ATP binding
  + 3 more...
.nuclear speck
.microtubule
.cytosol
  + 4 more...
101 EBI-533224,EBI-10311131 CABP5  
  .signal transduction .calcium ion binding .cytosol
102 EBI-533224,EBI-9679045 DMRT3  
  .male sex differentiation
.regulation of odontogenesis of dentin-containing tooth
.ventral spinal cord interneuron specification
  + 4 more...
.protein heterodimerization activity
.metal ion binding
.protein homodimerization activity
  + 2 more...
.nucleus
103 EBI-533224,EBI-10313866 C19orf66  
  .N/A .N/A .N/A
104 EBI-533224,EBI-10309345 TXNL4B  
  .mitotic nuclear division
.spliceosomal complex assembly
.N/A .U4/U6 x U5 tri-snRNP complex
.U5 snRNP
.spliceosomal complex
105 EBI-533224,EBI-8643161 C1orf109  
  .N/A .N/A .N/A
106 EBI-533224,EBI-742688 SPG21  
  .antigen receptor-mediated signaling pathway .CD4 receptor binding .trans-Golgi network transport vesicle
.endosome membrane
.cytosol
  + 3 more...
107 EBI-533224,EBI-739361 HSPB7  
  .regulation of heart contraction
.response to unfolded protein
.protein C-terminus binding .actin cytoskeleton
.Cajal body
.mitochondrion
  + 2 more...
108 EBI-533224,EBI-10320311 SEC14L4  
  .N/A .lipid binding
.transporter activity
.integral component of membrane
.intracellular
109 EBI-533224,EBI-10249760 NDOR1  
  .oxidation-reduction process
.small molecule metabolic process
.cellular response to menadione
  + 2 more...
.NADP binding
.flavin adenine dinucleotide binding
.oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
  + 4 more...
.perinuclear region of cytoplasm
.intermediate filament cytoskeleton
.cytosol
  + 2 more...
110 EBI-533224,EBI-748350 RTDR1  
  .N/A .N/A .N/A
111 EBI-533224,EBI-77889 MAD2L2  
  .negative regulation of transcription regulatory region DNA binding
.negative regulation of cell-cell adhesion mediated by cadherin
.negative regulation of canonical Wnt signaling pathway
  + 19 more...
.JUN kinase binding
.RNA polymerase II activating transcription factor binding
.zeta DNA polymerase complex
.spindle
.cytoplasm
  + 2 more...
112 EBI-533224,EBI-2686537 SCOC  
  .positive regulation of macroautophagy .N/A .cytosol
.Golgi membrane
113 EBI-533224,EBI-2805360 LNPEP  
  .membrane organization
.SMAD protein signal transduction
.antigen processing and presentation of exogenous peptide antigen via MHC class I
  + 7 more...
.zinc ion binding
.metallopeptidase activity
.aminopeptidase activity
.perinuclear region of cytoplasm
.early endosome lumen
.cytoplasmic vesicle membrane
  + 7 more...
114 EBI-533224,EBI-9057006 OSGIN1  
  .positive regulation of apoptotic process
.negative regulation of cell growth
.cell differentiation
.multicellular organismal development
.growth factor activity .N/A
115 EBI-533224,EBI-741528 CHIC2  
  .Golgi to plasma membrane transport .N/A .plasma membrane
.Golgi-associated vesicle
116 EBI-533224,EBI-747601 TRAPPC2L  
  .ER to Golgi vesicle-mediated transport .N/A .perinuclear region of cytoplasm
.Golgi apparatus
.endoplasmic reticulum
.cytoplasm
117 EBI-533224,EBI-311356 MYO5B  
  .transmembrane transport
.endosome localization
.vesicle-mediated transport
  + 4 more...
.Rab GTPase binding
.ATP binding
.microfilament motor activity
.extracellular exosome
.apical cortex
.protein complex
  + 2 more...
118 EBI-533224,EBI-10326138 EPB41L3  
  .protein localization to plasma membrane
.protein localization to juxtaparanode region of axon
.neuron projection morphogenesis
  + 8 more...
.structural constituent of cytoskeleton .juxtaparanode region of axon
.paranode region of axon
.axolemma
  + 5 more...
119 EBI-533224,EBI-1104564 MEMO1  
  .regulation of microtubule-based process .N/A .cytosol
.nucleus
120 EBI-533224,EBI-371892 EXOSC1  
  .exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
.gene expression
.rRNA processing
.nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
.RNA binding .cytosol
.cytoplasm
.nucleolus
  + 4 more...
121 EBI-533224,EBI-2557649 PPIL1  
  .protein folding
.protein peptidyl-prolyl isomerization
.mRNA splicing, via spliceosome
.peptidyl-prolyl cis-trans isomerase activity .catalytic step 2 spliceosome
.extracellular exosome
122 EBI-533224,EBI-744782 NME7  
  .left/right pattern formation
.ciliary receptor clustering involved in smoothened signaling pathway
.intraciliary transport
  + 6 more...
.metal ion binding
.ATP binding
.nucleoside diphosphate kinase activity
.ciliary basal body
.centrosome
123 EBI-533224,EBI-2321769 CHCHD2  
  .regulation of cellular response to hypoxia
.positive regulation of transcription from RNA polymerase II promoter
.transcription, DNA-templated
.sequence-specific DNA binding
.transcription factor binding
.mitochondrion
.nucleus
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue233
adrenal gland121
ascites75
bladder33
blood89
bone69
bone marrow266
brain187
connective tissue73
embryonic tissue136
esophagus148
eye143
heart245
intestine60
kidney123
liver19
lung149
lymph45
lymph node278
mammary gland33
mouth287
muscle56
nerve64
ovary68
pancreas89
pharynx417
pituitary gland181
placenta70
prostate36
salivary gland98
skin37
spleen168
stomach62
testis105
thymus100
thyroid107
trachea77
umbilical cord363
uterus116
vascular561
Health State
TissuesTPM*
normal335
adrenal tumor79
bladder carcinoma56
breast (mammary gland) tumor21
chondrosarcoma60
colorectal tumor35
esophageal tumor173
gastrointestinal tumor50
germ cell tumor129
glioma93
head and neck tumor104
kidney tumor145
leukemia95
liver tumor31
lung tumor58
lymphoma83
non-neoplasia155
ovarian tumor78
pancreatic tumor66
primitive neuroectodermal tumor of the CNS157
prostate cancer19
skin tumor15
soft tissue/muscle tissue tumor87
uterine tumor55
Developmental Stage
TissuesTPM*
adult81
embryoid body100
blastocyst32
neonate225
fetus362
infant85
juvenile89
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue58.5
adrenal gland30.8
appendix30.6
bone marrow12.5
cerebral cortex53.1
colon16.5
duodenum10.5
esophagus33.1
gallbladder78.9
heart muscle42.4
kidney10.3
liver8.3
lung39.2
lymph node44.8
ovary73.2
pancreas4.9
placenta47.6
prostate15.9
salivary gland16.4
skin21.3
small intestine10.7
spleen35.2
stomach14.9
testis25.4
thyroid gland48.5
urinary bladder61.6
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*602272, gene) Transcription factor 4; TCF4OMIM
2(#610954, phenotype) Pitt-hopkins syndrome; PTHSOMIM


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