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> Protein (NX_P15941)
Protein (NX_P15941)
Protein
Gene SymbolMUC1 to neXtProt (NX_P15941)
DescriptionMucin-1
Chromosome1
Location1q22 (155158300 ~ 155162707) to Ensembl
Sequene Features : Isoforms 17, Variants 47, PTMs 29 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.positive regulation of histone H4 acetylation
.cellular protein metabolic process
  + 9 more...
.transcription cofactor activity
.p53 binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.extracellular exosome
.vesicle
.apical plasma membrane
  + 4 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
17 47 29
2014-09-19protein level
17 40 29
2014-05-27protein level
17 37 29
2014-02-25protein level
17 38 29
2013-12-09protein level
17 28 29
2013-11-01protein level
17 24 29
2013-09-12protein level
17 24 29
2013-08-17protein level
14 24 29
2013-07-15protein level
10 16 20
2013-06-11protein level
10 16 20
2013-02-12protein level
10 13 149
2012-12-20protein level
10 13 149
2012-10-30protein level
10 11 149
2012-10-07protein level
10 11 20
2012-08-24protein level
10 7 20
2012-07-28protein level
10 7 20
2012-06-08protein level
10 30 20
2012-05-07protein level
10 30 20
2012-04-10protein level
10 30 20
2012-01-13protein level
10 30 20
2011-12-20protein level
10 41 20
2011-11-11protein level
10 41 20
2011-08-23protein level
10 41 20
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P15941-1
0 15 0 122028.7393
NX_P15941-10
1 7 0 21541.8483
NX_P15941-11
0 12 0 28387.202
NX_P15941-12
0 8 0 17079.1627
NX_P15941-13
3 7 0 21649.8465
NX_P15941-14
1 3 0 10396.1924
NX_P15941-15
1 8 0 23731.9616
NX_P15941-16
1 6 0 17275.7342
NX_P15941-17
2 11 0 28279.1171
NX_P15941-2
0 15 0 122867.1917
NX_P15941-3
1 14 0 121729.5557
NX_P15941-4
1 14 0 120948.2224
NX_P15941-5
1 6 0 103773.5215
NX_P15941-6
1 9 0 24550.3591
NX_P15941-7
0 12 0 27548.7496
NX_P15941-8
0 12 0 29573.7801
NX_P15941-9
0 8 0 18265.7408
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-2804728,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
2 EBI-2804728,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
3 EBI-2804728,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
4 EBI-2804728,EBI-4396776 MUC1  
  .negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
.positive regulation of histone H4 acetylation
.cellular protein metabolic process
  + 9 more...
.transcription cofactor activity
.p53 binding
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.extracellular exosome
.vesicle
.apical plasma membrane
  + 4 more...
5 EBI-10053698,EBI-969696 CEBPB  
  .positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.liver regeneration
.hepatocyte proliferation
  + 27 more...
.protein heterodimerization activity
.protein homodimerization activity
.RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
  + 6 more...
.CHOP-C/EBP complex
.nuclear matrix
.cytoplasm
  + 4 more...
6 EBI-2804728,EBI-742339 U2AF2  
  .negative regulation of mRNA splicing, via spliceosome
.positive regulation of RNA splicing
.mRNA 3'-end processing
  + 7 more...
.poly(A) RNA binding
.enzyme binding
.nucleotide binding
.nuclear speck
.spliceosomal complex
.nucleoplasm
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
ascites251
brain3
cervix20
connective tissue60
embryonic tissue4
esophagus49
eye23
intestine176
kidney37
liver48
lung104
mammary gland211
mouth136
muscle9
nerve64
ovary88
pancreas84
pharynx24
placenta24
prostate110
skin14
stomach585
testis4
uterus90
Health State
TissuesTPM*
normal27
breast (mammary gland) tumor204
cervical tumor28
chondrosarcoma60
colorectal tumor266
esophageal tumor57
gastrointestinal tumor472
germ cell tumor3
glioma27
head and neck tumor67
liver tumor20
lung tumor87
non-neoplasia124
ovarian tumor105
pancreatic tumor161
prostate cancer154
soft tissue/muscle tissue tumor7
uterine tumor166
Developmental Stage
TissuesTPM*
adult100
embryoid body14
fetus17
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue4.9
adrenal gland2.1
appendix28.5
bone marrow8.1
cerebral cortex2.6
colon90.3
duodenum25.6
esophagus86.6
gallbladder171.8
kidney102.6
lung312.6
lymph node1.9
ovary1.3
pancreas175.3
placenta8.3
prostate12.5
salivary gland31.3
skin12.5
small intestine5.5
spleen1.8
stomach766.3
testis28.4
thyroid gland5.7
urinary bladder53.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixMedium
breastMedium
bronchusMedium
cervix, uterineHigh
colonHigh
duodenumHigh
endometrium 1Medium
endometrium 2High
epididymisMedium
esophagusLow
fallopian tubeHigh
gallbladderHigh
kidneyMedium
liverLow
lungMedium
lymph nodeMedium
nasopharynxMedium
oral mucosaLow
pancreasMedium
parathyroid glandLow
placentaMedium
prostateLow
rectumHigh
salivary glandLow
seminal vesicleMedium
skin 1Low
skin 2Low
small intestineHigh
stomach 1High
stomach 2High
testisLow
thyroid glandLow
tonsilLow
urinary bladderMedium
vaginaLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*113720, gene) Breast cancer-associated df3 antigenOMIM
2(*158340, gene) Mucin 1, transmembrane; MUC1OMIM
3(%174000, phenotype) Medullary cystic kidney disease 1; MCKD1OMIM
4B-cell Non-Hodgkin LymphomaCGP


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