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> Protein (NX_P16284)
Protein (NX_P16284)
Protein
Gene SymbolPECAM1 to neXtProt (NX_P16284)
DescriptionPlatelet endothelial cell adhesion molecule
Chromosome17
Location17q23 (-1 ~ -1) to Ensembl
Sequene Features : Isoforms 6, Variants 5, PTMs 20 to neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.glomerular endothelium development
.diapedesis
.leukocyte migration
  + 8 more...
.N/A .extracellular exosome
.platelet alpha granule membrane
.cell junction
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
6 5 20
2014-09-19protein level
6 5 20
2014-02-25protein level
6 5 21
2013-12-09protein level
6 5 21
2013-11-01protein level
6 5 21
2013-09-12protein level
6 5 21
2013-08-17protein level
6 5 21
2013-07-15protein level
6 5 19
2013-06-11protein level
6 5 19
2013-02-12protein level
6 5 117
2012-12-20protein level
6 5 117
2012-10-30protein level
6 5 117
2012-10-07protein level
6 5 20
2012-08-24protein level
6 5 20
2012-07-28protein level
6 5 20
2012-06-08protein level
6 14 20
2012-05-07protein level
6 14 20
2012-04-10protein level
6 14 20
2012-01-13protein level
6 14 20
2011-12-20protein level
6 18 20
2011-11-11protein level
6 18 19
2011-08-23protein level
6 18 19
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P16284-1
0 39 0 82483.5989
NX_P16284-2
1 36 0 80427.6392
NX_P16284-3
0 38 0 80155.5183
NX_P16284-4
0 37 0 80367.4886
NX_P16284-5
0 36 0 79210.008
NX_P16284-6
0 37 0 81326.1183
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-716404,EBI-621482 SRC  
  .regulation of caveolin-mediated endocytosis
.negative regulation of intrinsic apoptotic signaling pathway
.negative regulation of extrinsic apoptotic signaling pathway
  + 100 more...
.scaffold protein binding
.growth factor receptor binding
.hormone receptor binding
  + 14 more...
.extracellular exosome
.perinuclear region of cytoplasm
.neuron projection
  + 13 more...
2 EBI-716404,EBI-702484 JUP  
  .regulation of ventricular cardiac muscle cell action potential
.positive regulation of canonical Wnt signaling pathway
.establishment of protein localization to plasma membrane
  + 20 more...
.cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
.cell adhesion molecule binding
.cadherin binding
  + 7 more...
.gamma-catenin-TCF7L2 complex
.extracellular exosome
.protein-DNA complex
  + 19 more...
3 EBI-716404,EBI-78260 PTPN6  
  .regulation of G1/S transition of mitotic cell cycle
.platelet aggregation
.regulation of ERK1 and ERK2 cascade
  + 33 more...
.protein kinase binding
.transmembrane receptor protein tyrosine phosphatase activity
.protein tyrosine phosphatase activity
.extracellular exosome
.alpha-beta T cell receptor complex
.membrane
  + 5 more...
4 EBI-716404,EBI-491549 CTNNB1  
  .negative regulation of apoptotic signaling pathway
.positive regulation of DNA-templated transcription, initiation
.positive regulation of determination of dorsal identity
  + 126 more...
.euchromatin binding
.R-SMAD binding
.I-SMAD binding
  + 18 more...
.cell periphery
.beta-catenin-TCF7L2 complex
.extracellular exosome
  + 32 more...
5 EBI-716404,EBI-297779 PTPN11  
  .positive regulation of glucose import in response to insulin stimulus
.positive regulation of ERK1 and ERK2 cascade
.regulation of type I interferon-mediated signaling pathway
  + 46 more...
.insulin receptor binding
.SH3/SH2 adaptor activity
.non-membrane spanning protein tyrosine phosphatase activity
  + 2 more...
.protein complex
.cytosol
.mitochondrion
  + 2 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue466
adrenal gland60
blood73
bone marrow41
brain21
connective tissue20
eye14
heart22
intestine12
kidney28
larynx85
liver4
lung56
lymph node66
mammary gland19
mouth45
muscle84
nerve64
ovary29
pancreas18
parathyroid97
pharynx98
placenta162
prostate15
skin9
stomach41
testis4
thymus37
thyroid21
tonsil58
umbilical cord217
uterus8
vascular135
Health State
TissuesTPM*
normal40
adrenal tumor79
breast (mammary gland) tumor32
chondrosarcoma96
colorectal tumor8
gastrointestinal tumor33
germ cell tumor3
glioma9
head and neck tumor14
kidney tumor14
leukemia42
non-neoplasia72
pancreatic tumor133
soft tissue/muscle tissue tumor39
uterine tumor22
Developmental Stage
TissuesTPM*
adult50
neonate96
fetus23
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Disease
No.Disease DescriptionRef.
1(*173445, gene) Platelet-endothelial cell adhesion molecule 1; PECAM1OMIM


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