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> Protein (NX_P16333)
Protein (NX_P16333)
Protein
Gene SymbolNCK1 to neXtProt (NX_P16333)
DescriptionCytoplasmic protein NCK1
Chromosome3
Location3q22.3 (136581050 ~ 136668665) to Ensembl
Sequene Features : Isoforms 2, Variants 39, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
.negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation
.negative regulation of PERK-mediated unfolded protein response
  + 23 more...
.eukaryotic initiation factor eIF2 binding
.receptor tyrosine kinase binding
.protein binding, bridging
  + 5 more...
.vesicle membrane
.cell-cell junction
.plasma membrane
  + 6 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 39 5
2014-09-19protein level
2 27 5
2014-05-27protein level
2 27 5
2014-02-25protein level
2 28 5
2013-12-09protein level
2 23 5
2013-11-01protein level
2 22 5
2013-09-12protein level
2 22 4
2013-08-17protein level
2 22 4
2013-07-15protein level
2 19 4
2013-06-11protein level
2 19 4
2013-02-12protein level
2 10 9
2012-12-20protein level
2 8 9
2012-10-30protein level
2 11 9
2012-10-07protein level
2 11 5
2012-08-24protein level
2 11 5
2012-07-28protein level
2 10 5
2012-06-08protein level
2 14 5
2012-05-07protein level
2 11 5
2012-04-10protein level
1 11 5
2012-01-13protein level
1 8 5
2011-12-20protein level
1 8 5
2011-11-11protein level
1 8 5
2011-08-23protein level
1 4 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P16333-1
3 15 1 42837.2925
NX_P16333-2
1 15 0 35488.3925
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-389883,EBI-1751853 F2RL2  
  .platelet activation
.response to wounding
.metabolic process
.blood coagulation
.thrombin receptor activity
.phosphatidylinositol phospholipase C activity
.apical plasma membrane
.integral component of plasma membrane
.plasma membrane
.extracellular region
2 EBI-389883,EBI-1756778 TULP1  
  .retina development in camera-type eye
.detection of light stimulus involved in visual perception
.positive regulation of phagocytosis
  + 7 more...
.actin filament binding
.G-protein coupled photoreceptor activity
.phosphatidylinositol-4,5-bisphosphate binding
.synapse
.cell projection
.cell junction
  + 5 more...
3 EBI-389883,EBI-641107 PIK3C2B  
  .cell chemotaxis
.phosphatidylinositol phosphorylation
.innate immune response
  + 10 more...
.phosphatidylinositol binding
.1-phosphatidylinositol-4-phosphate 3-kinase activity
.1-phosphatidylinositol-3-kinase activity
  + 2 more...
.endocytic vesicle
.phosphatidylinositol 3-kinase complex
.plasma membrane
  + 4 more...
4 EBI-389883,EBI-1753207 DLGAP1  
  .synaptic transmission .N/A .neuronal postsynaptic density
.postsynaptic membrane
.cell junction
5 EBI-389883,EBI-310513 SYNJ2  
  .phosphatidylinositol dephosphorylation
.small molecule metabolic process
.phosphatidylinositol biosynthetic process
.phospholipid metabolic process
.phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
.RNA binding
.nucleotide binding
.membrane
.cytosol
6 EBI-389883,EBI-311099 ARHGEF11  
  .apoptotic signaling pathway
.regulation of small GTPase mediated signal transduction
.neurotrophin TRK receptor signaling pathway
  + 14 more...
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.G-protein coupled receptor binding
.membrane
.cytosol
.cytoplasm
.intracellular
7 EBI-389883,EBI-1753267 FYB  
  .T cell receptor signaling pathway
.intracellular signal transduction
.signal transduction
  + 3 more...
.receptor binding .actin cytoskeleton
.cytosol
.nucleus
8 EBI-389883,EBI-713419 HNRNPR  
  .gene expression
.RNA splicing
.mRNA processing
.mRNA splicing, via spliceosome
.poly(A) RNA binding
.RNA binding
.nucleotide binding
.catalytic step 2 spliceosome
.ribonucleoprotein complex
.cytoplasm
  + 2 more...
9 EBI-389883,EBI-1752146 TGOLN2  
  .N/A .N/A .transport vesicle
.integral component of membrane
.plasma membrane
  + 3 more...
10 EBI-389883,EBI-346356 WIPF1  
  .response to other organism
.innate immune response
.Fc-gamma receptor signaling pathway involved in phagocytosis
  + 4 more...
.profilin binding
.actin binding
.cytoplasmic membrane-bounded vesicle
.actin cytoskeleton
.actin filament
  + 2 more...
11 EBI-389883,EBI-748043 GSTZ1  
  .glutathione derivative biosynthetic process
.oxidation-reduction process
.small molecule metabolic process
  + 5 more...
.protein homodimerization activity
.maleylacetoacetate isomerase activity
.glutathione peroxidase activity
.glutathione transferase activity
.cytosol
.mitochondrion
12 EBI-389883,EBI-1753081 AIRE  
  .positive regulation of transcription from RNA polymerase II promoter
.positive regulation of transcription, DNA-templated
.humoral immune response
  + 2 more...
.translation regulator activity
.transcription regulatory region DNA binding
.histone binding
  + 4 more...
.cytoplasm
.nucleus
13 EBI-389883,EBI-996920 NPHS1  
  .glomerular visceral epithelial cell development
.regulation of excretion
.glomerular basement membrane development
  + 6 more...
.myosin binding .extracellular exosome
.membrane raft
.protein complex
  + 4 more...
14 EBI-389883,EBI-518647 JAK2  
  .activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
.extrinsic apoptotic signaling pathway
.response to interleukin-12
  + 76 more...
.histone binding
.SH2 domain binding
.histone kinase activity (H3-Y41 specific)
  + 9 more...
.membrane raft
.endosome lumen
.extrinsic component of cytoplasmic side of plasma membrane
  + 7 more...
15 EBI-389883,EBI-1753504 SLC24A1  
  .transmembrane transport
.sodium ion transmembrane transport
.rhodopsin mediated signaling pathway
  + 6 more...
.symporter activity
.calcium, potassium:sodium antiporter activity
.outer membrane
.membrane
.integral component of plasma membrane
.plasma membrane
16 EBI-389883,EBI-723869 BRD4  
  .negative regulation of DNA damage checkpoint
.regulation of phosphorylation of RNA polymerase II C-terminal domain
.regulation of inflammatory response
  + 15 more...
.lysine-acetylated histone binding
.chromatin binding
.DNA binding
.p53 binding
.positive transcription elongation factor complex b
.cytoplasm
.chromosome
  + 4 more...
17 EBI-389883,EBI-1754409 PHACTR2  
  .N/A .protein phosphatase inhibitor activity .N/A
18 EBI-389883,EBI-1753538 SEMA7A  
  .positive regulation of ERK1 and ERK2 cascade
.positive regulation of macrophage cytokine production
.regulation of inflammatory response
  + 9 more...
.receptor activity .anchored component of membrane
.membrane
.external side of plasma membrane
.plasma membrane
19 EBI-389883,EBI-352089 FLNB  
  .cell differentiation
.actin cytoskeleton organization
.cytokine-mediated signaling pathway
  + 3 more...
.poly(A) RNA binding
.identical protein binding
.actin binding
.extracellular exosome
.Z disc
.integral component of membrane
  + 7 more...
20 EBI-389883,EBI-1759806 FOXH1  
  .negative regulation of androgen receptor activity
.nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry
.negative regulation of androgen receptor signaling pathway
  + 14 more...
.R-SMAD binding
.co-SMAD binding
.androgen receptor binding
  + 11 more...
.activin responsive factor complex
.transcription factor complex
.nucleoplasm
  + 2 more...
21 EBI-389883,EBI-1752541 DLGAP3  
  .signaling .beta-amyloid binding .postsynaptic membrane
.cell junction
.postsynaptic density
22 EBI-389883,EBI-375543 ABL1  
  .regulation of response to DNA damage stimulus
.negative regulation of cellular senescence
.negative regulation of endothelial cell apoptotic process
  + 73 more...
.proline-rich region binding
.mitogen-activated protein kinase binding
.manganese ion binding
  + 12 more...
.perinuclear region of cytoplasm
.nuclear membrane
.cell leading edge
  + 8 more...
23 EBI-389883,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
24 EBI-389883,EBI-1211297 CD3E  
  .apoptotic signaling pathway
.T cell receptor signaling pathway
.positive regulation of calcium-mediated signaling
  + 20 more...
.protein heterodimerization activity
.T cell receptor binding
.receptor signaling complex scaffold activity
  + 4 more...
.alpha-beta T cell receptor complex
.T cell receptor complex
.external side of plasma membrane
  + 4 more...
25 EBI-389883,EBI-298336 SP1  
  .definitive hemopoiesis
.embryonic process involved in female pregnancy
.embryonic skeletal system development
  + 19 more...
.HMG box domain binding
.metal ion binding
.transcription regulatory region DNA binding
  + 16 more...
.protein-DNA complex
.cytoplasm
.nucleoplasm
.nucleus
26 EBI-389883,EBI-1039152 MET  
  .positive regulation of endothelial cell chemotaxis
.negative regulation of hydrogen peroxide-mediated programmed cell death
.semaphorin-plexin signaling pathway
  + 22 more...
.protein phosphatase binding
.ATP binding
.hepatocyte growth factor-activated receptor activity
.protein tyrosine kinase activity
.integral component of membrane
.cell surface
.basal plasma membrane
  + 3 more...
27 EBI-389883,EBI-968703 RRAS  
  .regulation of ERK1 and ERK2 cascade
.face morphogenesis
.regulation of protein kinase B signaling
  + 7 more...
.protein complex binding
.GDP binding
.GTP binding
.GTPase activity
.extracellular exosome
.focal adhesion
.plasma membrane
28 EBI-389883,EBI-358163 HIST1H1E  
  .nucleosome positioning
.nucleosome assembly
.poly(A) RNA binding
.chromatin DNA binding
.extracellular exosome
.nuclear heterochromatin
.nucleus
.nucleosome
29 EBI-389883,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
30 EBI-389883,EBI-286316 GHR  
  .JAK-STAT cascade involved in growth hormone signaling pathway
.growth hormone receptor signaling pathway
.positive regulation of peptidyl-tyrosine phosphorylation
  + 25 more...
.proline-rich region binding
.protein homodimerization activity
.protein kinase binding
  + 3 more...
.growth hormone receptor complex
.receptor complex
.integral component of membrane
  + 5 more...
31 EBI-389883,EBI-1753221 C6  
  .positive regulation of angiogenesis
.innate immune response
.regulation of complement activation
  + 5 more...
.N/A .extracellular exosome
.membrane attack complex
.extracellular region
32 EBI-389883,EBI-1752200 GNS  
  .small molecule metabolic process
.keratan sulfate catabolic process
.keratan sulfate metabolic process
  + 3 more...
.metal ion binding
.sulfuric ester hydrolase activity
.N-acetylglucosamine-6-sulfatase activity
.extracellular exosome
.lysosomal lumen
33 EBI-389883,EBI-1755109 RAG1  
  .nucleic acid phosphodiester bond hydrolysis
.negative regulation of thymocyte apoptotic process
.protein autoubiquitination
  + 12 more...
.metal ion binding
.sequence-specific DNA binding
.protein homodimerization activity
  + 6 more...
.nucleus
34 EBI-389883,EBI-1268770 CAST  
  .negative regulation of type B pancreatic cell apoptotic process
.negative regulation of endopeptidase activity
.poly(A) RNA binding
.cysteine-type endopeptidase inhibitor activity
.endopeptidase inhibitor activity
.membrane
.cytosol
.cytoplasm
35 EBI-389883,EBI-1026476 RASA1  
  .regulation of RNA metabolic process
.blood vessel morphogenesis
.ephrin receptor signaling pathway
  + 14 more...
.GTPase binding
.potassium channel inhibitor activity
.receptor binding
  + 2 more...
.intrinsic component of the cytoplasmic side of the plasma membrane
.cytosol
.cytoplasm
.ruffle
36 EBI-389883,EBI-1165705 CD247  
  .T cell receptor signaling pathway
.regulation of immune response
.regulation of defense response to virus by virus
  + 4 more...
.protein homodimerization activity
.identical protein binding
.transmembrane signaling receptor activity
.alpha-beta T cell receptor complex
.T cell receptor complex
.integral component of membrane
  + 2 more...
37 EBI-389883,EBI-356849 RPL13  
  .cellular protein metabolic process
.viral transcription
.viral life cycle
  + 8 more...
.poly(A) RNA binding
.structural constituent of ribosome
.RNA binding
.cytosolic ribosome
.cytosolic large ribosomal subunit
.membrane
  + 4 more...
38 EBI-389883,EBI-715255 MAP4  
  .cell division
.establishment of spindle orientation
.microtubule sliding
.mitotic spindle organization
.poly(A) RNA binding
.structural molecule activity
.mitotic spindle
.extracellular exosome
.microtubule cytoskeleton
  + 4 more...
39 EBI-389883,EBI-710431 PTPN4  
  .peptidyl-tyrosine dephosphorylation
.protein dephosphorylation
.non-membrane spanning protein tyrosine phosphatase activity .cytoplasmic side of plasma membrane
.cytoskeleton
.cytoplasm
40 EBI-389883,EBI-994813 CDC27  
  .protein K11-linked ubiquitination
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
.positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
  + 6 more...
.protein phosphatase binding .cytosol
.spindle
.centrosome
  + 4 more...
41 EBI-389883,EBI-724784 FCGR2B  
  .regulation of immune response
.viral process
.signal transduction
.immune response
.N/A .integral component of membrane
.plasma membrane
42 EBI-389883,EBI-1396036 FCGR2C  
  .signal transduction
.immune response
.transmembrane signaling receptor activity .integral component of membrane
.plasma membrane
.cytoplasm
43 EBI-389883,EBI-1005487 KDR  
  .positive regulation of vasculogenesis
.negative regulation of endothelial cell apoptotic process
.positive regulation of ERK1 and ERK2 cascade
  + 39 more...
.Hsp90 protein binding
.vascular endothelial growth factor binding
.growth factor binding
  + 6 more...
.sorting endosome
.membrane raft
.cell junction
  + 10 more...
44 EBI-389883,EBI-1758534 ELK3  
  .positive regulation of transcription from RNA polymerase II promoter
.negative regulation of transcription, DNA-templated
.wound healing
  + 5 more...
.purine-rich negative regulatory element binding
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
  + 3 more...
.intracellular membrane-bounded organelle
.mitochondrion
.nucleoplasm
.nucleus
45 EBI-389883,EBI-455283 TMPO  
  .N/A .lamin binding
.DNA binding
.nuclear membrane
.integral component of membrane
.membrane
  + 4 more...
46 EBI-389883,EBI-396684 EPS15  
  .clathrin coat assembly
.viral entry into host cell
.negative regulation of epidermal growth factor receptor signaling pathway
  + 7 more...
.polyubiquitin binding
.calcium ion binding
.ciliary membrane
.intracellular membrane-bounded organelle
.early endosome membrane
  + 6 more...
47 EBI-389883,EBI-1102694 ABL2  
  .negative regulation of endothelial cell apoptotic process
.regulation of actin cytoskeleton reorganization
.regulation of cell motility
  + 41 more...
.actin filament binding
.manganese ion binding
.ATP binding
  + 6 more...
.dendritic spine
.extrinsic component of cytoplasmic side of plasma membrane
.lamellipodium
  + 3 more...
48 EBI-389883,EBI-1391923 NKX2-1  
  .Type II pneumocyte differentiation
.Clara cell differentiation
.epithelial tube branching involved in lung morphogenesis
  + 32 more...
.transcription regulatory region DNA binding
.sequence-specific DNA binding
.enzyme binding
  + 5 more...
.transcription factor complex
.nucleoplasm
.nucleus
49 EBI-389883,EBI-1754719 ID4  
  .negative regulation of oligodendrocyte differentiation
.negative regulation of astrocyte differentiation
.positive regulation of transcription from RNA polymerase II promoter
  + 16 more...
.transcription corepressor activity .cytoplasm
.nucleus
50 EBI-389883,EBI-1752413 CYP4F2  
  .omega-hydroxylase P450 pathway
.oxidation-reduction process
.sodium ion homeostasis
  + 20 more...
.tocotrienol omega-hydroxylase activity
.alpha-tocopherol omega-hydroxylase activity
.arachidonic acid omega-hydroxylase activity
  + 6 more...
.intracellular membrane-bounded organelle
.apical plasma membrane
.endoplasmic reticulum membrane
.cytoplasm
51 EBI-389883,EBI-366493 RPP38  
  .RNA phosphodiester bond hydrolysis, endonucleolytic
.RNA phosphodiester bond hydrolysis
.tRNA processing
.ribonuclease P activity .nucleolar ribonuclease P complex
.nucleus
52 EBI-389883,EBI-1751903 CNTNAP1  
  .neuromuscular process controlling balance
.neuromuscular process controlling posture
.neuron projection morphogenesis
  + 9 more...
.SH3 domain binding
.SH3/SH2 adaptor activity
.receptor activity
.paranode region of axon
.integral component of membrane
.voltage-gated potassium channel complex
.integral component of plasma membrane
53 EBI-389883,EBI-1171238 DAB2  
  .negative regulation of extrinsic apoptotic signaling pathway
.positive regulation of integrin-mediated signaling pathway
.positive regulation of early endosome to late endosome transport
  + 35 more...
.SMAD binding
.cargo receptor activity
.clathrin adaptor activity
  + 2 more...
.extracellular exosome
.intracellular membrane-bounded organelle
.clathrin-coated vesicle membrane
  + 8 more...
54 EBI-389883,EBI-713135 DNM1  
  .clathrin-mediated endocytosis
.ephrin receptor signaling pathway
.receptor internalization
  + 4 more...
.poly(A) RNA binding
.identical protein binding
.protein kinase binding
  + 2 more...
.extracellular exosome
.membrane coat
.plasma membrane
.microtubule
55 EBI-389883,EBI-297487 SOS1  
  .apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 16 more...
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.Ras guanyl-nucleotide exchange factor activity
.DNA binding
.neuronal cell body
.postsynaptic density
.plasma membrane
.cytosol
56 EBI-389883,EBI-298181 SOS2  
  .apoptotic signaling pathway
.positive regulation of small GTPase mediated signal transduction
.regulation of small GTPase mediated signal transduction
  + 4 more...
.Rho guanyl-nucleotide exchange factor activity
.DNA binding
.cytosol
57 EBI-389883,EBI-1752525 PDIA2  
  .regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
.oxidation-reduction process
.cell redox homeostasis
  + 5 more...
.disulfide oxidoreductase activity
.steroid binding
.protein disulfide isomerase activity
.endoplasmic reticulum lumen
.endoplasmic reticulum
58 EBI-389883,EBI-346946 LCP2  
  .T cell receptor signaling pathway
.cytokine secretion
.positive regulation of protein kinase activity
  + 8 more...
.N/A .cell-cell junction
.cytosol
59 EBI-389883,EBI-1020839 CHAF1A  
  .chromatin assembly
.cell cycle
.protein complex assembly
  + 3 more...
.chromo shadow domain binding
.unfolded protein binding
.identical protein binding
.chromatin binding
.protein complex
.CAF-1 complex
.nuclear chromatin
60 EBI-389883,EBI-1045887 PAK2  
  .negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
.positive regulation of extrinsic apoptotic signaling pathway
.positive regulation of protein tyrosine kinase activity
  + 30 more...
.Rac GTPase binding
.identical protein binding
.protein tyrosine kinase activator activity
  + 4 more...
.perinuclear region of cytoplasm
.plasma membrane
.cytosol
  + 2 more...
61 EBI-389883,EBI-744027 CBLB  
  .negative regulation of T cell receptor signaling pathway
.negative regulation of alpha-beta T cell proliferation
.positive regulation of protein catabolic process
  + 7 more...
.ligase activity
.zinc ion binding
.calcium ion binding
  + 2 more...
.plasma membrane
.cytosol
.cytoplasm
.nucleoplasm
62 EBI-389883,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
63 EBI-389883,EBI-1644065 SHROOM2  
  .camera-type eye morphogenesis
.cell-cell junction maintenance
.apical protein localization
  + 11 more...
.actin filament binding
.ligand-gated sodium channel activity
.beta-catenin binding
.actin binding
.extracellular exosome
.neuronal cell body
.filamentous actin
  + 7 more...
64 EBI-389883,EBI-976876 RAPGEF1  
  .negative regulation of neural precursor cell proliferation
.cellular response to nerve growth factor stimulus
.regulation of cell junction assembly
  + 17 more...
.Rap guanyl-nucleotide exchange factor activity .cytosol
.early endosome
.endosome
65 EBI-389883,EBI-310585 CKAP5  
  .cell division
.centrosome organization
.RNA transport
  + 7 more...
.N/A .protein complex
.membrane
.cytosol
  + 2 more...
66 EBI-389883,EBI-1755945 DAG1  
  .basement membrane organization
.commissural neuron axon guidance
.branching involved in salivary gland morphogenesis
  + 15 more...
.alpha-actinin binding
.laminin-1 binding
.SH2 domain binding
  + 6 more...
.contractile ring
.extracellular exosome
.postsynaptic membrane
  + 20 more...
67 EBI-389883,EBI-1752620 SNX17  
  .regulation of endocytosis
.endosomal transport
.signal transduction
  + 3 more...
.low-density lipoprotein particle receptor binding
.phosphatidylinositol binding
.protein C-terminus binding
.receptor binding
.protein complex
.intracellular membrane-bounded organelle
.cytoplasmic vesicle membrane
  + 8 more...
68 EBI-389883,EBI-1646426 AGER  
  .positive regulation of NF-kappaB transcription factor activity
.induction of positive chemotaxis
.innate immune response
  + 4 more...
.S100 protein binding
.identical protein binding
.transmembrane signaling receptor activity
.receptor activity
.integral component of plasma membrane
.plasma membrane
.extracellular region
69 EBI-389883,EBI-1761369 TPSAB1  
  .extracellular matrix organization
.extracellular matrix disassembly
.defense response
.serine-type peptidase activity
.serine-type endopeptidase activity
.extracellular space
.extracellular region
70 EBI-389883,EBI-968482 MYLK  
  .activation of mitophagy in response to mitochondrial depolarization
.positive regulation of wound healing
.cellular hypotonic response
  + 11 more...
.metal ion binding
.ATP binding
.myosin light chain kinase activity
.calmodulin-dependent protein kinase activity
.extracellular exosome
.cleavage furrow
.lamellipodium
  + 4 more...
71 EBI-389883,EBI-1752361 DOCK3  
  .small GTPase mediated signal transduction .guanyl-nucleotide exchange factor activity .cytoplasm
72 EBI-389883,EBI-1570523 RIN3  
  .positive regulation of GTPase activity
.signal transduction
.endocytosis
.Rab GTPase binding
.Rab guanyl-nucleotide exchange factor activity
.GTPase activator activity
.cytoplasmic vesicle
.cytoplasmic membrane-bounded vesicle
.early endosome
73 EBI-389883,EBI-347721 NELFB  
  .positive regulation of viral transcription
.negative regulation of transcription, DNA-templated
.viral process
  + 3 more...
.N/A .NELF complex
.cytoplasm
.nucleoplasm
74 EBI-389883,EBI-881 MAP4K1  
  .protein autophosphorylation
.regulation of apoptotic process
.intracellular signal transduction
  + 7 more...
.MAP kinase kinase kinase kinase activity
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.membrane
.cytoplasm
75 EBI-389883,EBI-1752755 DLX4  
  .multicellular organismal development
.regulation of transcription, DNA-templated
.negative regulation of transcription from RNA polymerase II promoter
.sequence-specific DNA binding
.sequence-specific DNA binding transcription factor activity
.RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
.RNA polymerase II core promoter proximal region sequence-specific DNA binding
.nucleus
76 EBI-389883,EBI-1752088 SCARF2  
  .heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules .scavenger receptor activity .integral component of membrane
.focal adhesion
77 EBI-389883,EBI-1751918 ASB16  
  .intracellular signal transduction
.protein ubiquitination
.N/A .N/A
78 EBI-389883,EBI-1752583 VPS13A  
  .protein retention in Golgi apparatus
.social behavior
.protein localization
  + 4 more...
.N/A .dense core granule
.extrinsic component of membrane
.intracellular
79 EBI-389883,EBI-765739 SPEN  
  .positive regulation of neurogenesis
.positive regulation of transcription, DNA-templated
.negative regulation of transcription, DNA-templated
  + 3 more...
.poly(A) RNA binding
.transcription corepressor activity
.sequence-specific DNA binding transcription factor activity
  + 4 more...
.extracellular exosome
.transcriptional repressor complex
.nucleoplasm
80 EBI-389883,EBI-743184 GAD1  
  .response to drug
.neurotransmitter biosynthetic process
.protein-pyridoxal-5-phosphate linkage
  + 5 more...
.pyridoxal phosphate binding
.glutamate binding
.glutamate decarboxylase activity
.clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
.vesicle membrane
.plasma membrane
.intracellular
81 EBI-389883,EBI-1752811 FAM110A  
  .N/A .N/A .microtubule organizing center
.cytoplasm
.spindle pole
82 EBI-389883,EBI-1756205 TRAIP  
  .negative regulation of tumor necrosis factor-mediated signaling pathway
.cell proliferation
.signal transduction
.apoptotic process
.ligase activity
.zinc ion binding
.receptor signaling protein activity
.ubiquitin-protein transferase activity
.perinuclear region of cytoplasm
.nucleolus
83 EBI-389883,EBI-1753064 PRX  
  .axon ensheathment .N/A .plasma membrane
.cytoplasm
.nucleus
84 EBI-389883,EBI-1761329 LRRC3  
  .N/A .N/A .integral component of membrane
85 EBI-389883,EBI-1752330 SHANK3  
  .positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
.positive regulation of excitatory postsynaptic membrane potential
.regulation of long term synaptic depression
  + 25 more...
.scaffold protein binding
.identical protein binding
.ionotropic glutamate receptor binding
  + 4 more...
.neuronal postsynaptic density
.ciliary membrane
.postsynaptic membrane
  + 6 more...
86 EBI-389883,EBI-1752795 DUSP15  
  .positive regulation of JNK cascade
.regulation of cell proliferation
.transforming growth factor beta receptor signaling pathway
.protein dephosphorylation
.protein tyrosine/serine/threonine phosphatase activity
.protein tyrosine phosphatase activity
.plasma membrane
.cytoplasm
87 EBI-389883,EBI-1761423 ABCG5  
  .transmembrane transport
.negative regulation of intestinal cholesterol absorption
.small molecule metabolic process
  + 9 more...
.protein heterodimerization activity
.cholesterol transporter activity
.ATPase activity
.ATP binding
.receptor complex
.ATP-binding cassette (ABC) transporter complex
.apical plasma membrane
.plasma membrane
88 EBI-389883,EBI-723127 SUV39H2  
  .cellular response to hypoxia
.rhythmic process
.negative regulation of transcription, DNA-templated
  + 10 more...
.histone methyltransferase activity (H3-K9 specific)
.zinc ion binding
.chromatin binding
.transcription regulatory region sequence-specific DNA binding
.nuclear heterochromatin
.nucleoplasm
.chromatin
.chromosome, centromeric region
89 EBI-389883,EBI-1054039 ECT2  
  .apoptotic signaling pathway
.activation of GTPase activity
.cellular response to ionizing radiation
  + 19 more...
.protein homodimerization activity
.GTPase activator activity
.Rho guanyl-nucleotide exchange factor activity
.signal transducer activity
.centralspindlin complex
.mitotic spindle
.intracellular membrane-bounded organelle
  + 8 more...
90 EBI-389883,EBI-751335 ISG20L2  
  .ribosome biogenesis .poly(A) RNA binding
.exonuclease activity
.nucleolus
.nucleoplasm
91 EBI-389883,EBI-739510 TRIM39  
  .positive regulation of apoptotic signaling pathway
.negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
.protein ubiquitination
.apoptotic process
.identical protein binding
.ligase activity
.zinc ion binding
.cytosol
.mitochondrion
92 EBI-389883,EBI-1753293 MEPE  
  .regulation of bone remodeling
.biomineral tissue development
.negative regulation of bone mineralization
.skeletal system development
.extracellular matrix structural constituent .proteinaceous extracellular matrix
93 EBI-389883,EBI-308417 CELSR3  
  .cilium assembly
.regulation of protein localization
.axonal fasciculation
  + 3 more...
.calcium ion binding
.G-protein coupled receptor activity
.integral component of membrane
.plasma membrane
94 EBI-389883,EBI-1754943 GLTSCR1  
  .N/A .N/A .N/A
95 EBI-389883,EBI-1751965 SEPN1  
  .N/A .calcium ion binding .endoplasmic reticulum membrane
96 EBI-389883,EBI-1753397 DLGAP2  
  .neuron-neuron synaptic transmission .N/A .postsynaptic membrane
.cell junction
.postsynaptic density
.neurofilament
97 EBI-389883,EBI-724156 GABBR1  
  .synaptic transmission
.gamma-aminobutyric acid signaling pathway
.negative regulation of adenylate cyclase activity
.adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
.G-protein coupled GABA receptor activity .postsynaptic membrane
.presynaptic membrane
.G-protein coupled receptor heterodimeric complex
  + 6 more...
98 EBI-389883,EBI-1759386 SLC23A1  
  .transepithelial L-ascorbic acid transport
.dehydroascorbic acid transport
.small molecule metabolic process
  + 12 more...
.sodium-dependent L-ascorbate transmembrane transporter activity
.dehydroascorbic acid transporter activity
.L-ascorbic acid transporter activity
  + 3 more...
.extracellular exosome
.intracellular organelle
.apical plasma membrane
  + 6 more...
99 EBI-389883,EBI-934890 BAZ2A  
  .histone H4 deacetylation
.heterochromatin assembly involved in chromatin silencing
.histone H3-K9 methylation
  + 10 more...
.lysine-acetylated histone binding
.ligand-dependent nuclear receptor binding
.zinc ion binding
  + 2 more...
.rDNA heterochromatin
.nucleolus
.chromatin silencing complex
100 EBI-389883,EBI-302355 PNMA2  
  .positive regulation of apoptotic process .N/A .nucleolus
101 EBI-389883,EBI-1753470 BRPF3  
  .histone H3 acetylation
.platelet activation
.blood coagulation
.platelet degranulation
.zinc ion binding .MOZ/MORF histone acetyltransferase complex
.cytosol
.extracellular region
102 EBI-389883,EBI-346622 ASAP1  
  .cilium morphogenesis
.organelle organization
.zinc ion binding
.phosphatidylinositol-3,4,5-trisphosphate binding
.phosphatidylinositol-4,5-bisphosphate binding
.GTPase activator activity
.membrane
.cytosol
103 EBI-389883,EBI-1037322 TPX2  
  .regulation of mitotic spindle organization
.cell division
.activation of protein kinase activity
  + 3 more...
.protein kinase binding
.GTP binding
.ATP binding
.axon hillock
.microtubule cytoskeleton
.microtubule
  + 5 more...
104 EBI-389883,EBI-765774 KMT2B  
  .histone H3-K4 trimethylation
.regulation of histone H3-K4 methylation
.histone H3-K4 methylation
  + 7 more...
.histone methyltransferase activity (H3-K4 specific)
.zinc ion binding
.sequence-specific DNA binding transcription factor activity
.DNA binding
.histone methyltransferase complex
.nucleoplasm
.nucleus
105 EBI-389883,EBI-1752602 SNX12  
  .negative regulation of early endosome to late endosome transport
.negative regulation of protein transport
.negative regulation of protein catabolic process
  + 6 more...
.phosphatidylinositol binding
.enzyme binding
.extracellular exosome
.extrinsic component of membrane
.early endosome
.endosome
106 EBI-389883,EBI-1570571 SHANK2  
  .vocalization behavior
.long term synaptic depression
.long-term synaptic potentiation
  + 6 more...
.ionotropic glutamate receptor binding
.GKAP/Homer scaffold activity
.ciliary membrane
.postsynaptic membrane
.dendritic spine
  + 12 more...
107 EBI-389883,EBI-1756749 RIMS2  
  .positive regulation of excitatory postsynaptic membrane potential
.positive regulation of dendrite extension
.positive regulation of inhibitory postsynaptic membrane potential
  + 9 more...
.metal ion binding
.ion channel binding
.extracellular exosome
.presynaptic active zone
.protein complex
  + 2 more...
108 EBI-389883,EBI-722139 DLGAP4  
  .signaling .N/A .synapse
.membrane
109 EBI-389883,EBI-1279 MAP4K5  
  .regulation of apoptotic process
.intracellular signal transduction
.regulation of mitotic cell cycle
  + 3 more...
.MAP kinase kinase kinase kinase activity
.ATP binding
.protein serine/threonine kinase activity
.protein kinase activity
.plasma membrane
.cytoplasm
110 EBI-389883,EBI-1752557 SNX8  
  .early endosome to Golgi transport
.vesicle organization
.endocytosis
.intracellular protein transport
.identical protein binding
.phosphatidylinositol binding
.intracellular membrane-bounded organelle
.early endosome membrane
.extrinsic component of membrane
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
adrenal gland30
bladder33
blood8
bone marrow20
brain31
cervix61
connective tissue33
ear62
embryonic tissue4
esophagus49
eye9
heart55
intestine25
kidney47
larynx127
liver24
lung11
lymph node89
mammary gland26
mouth30
muscle47
nerve64
ovary9
pancreas4
parathyroid48
pharynx122
placenta28
prostate10
skin4
spleen37
stomach10
testis48
thymus175
trachea38
umbilical cord290
uterus25
vascular38
Health State
TissuesTPM*
normal34
bladder carcinoma56
breast (mammary gland) tumor21
cervical tumor57
chondrosarcoma12
colorectal tumor26
esophageal tumor57
germ cell tumor15
glioma37
head and neck tumor29
kidney tumor29
leukemia10
liver tumor41
lung tumor9
lymphoma13
non-neoplasia41
ovarian tumor13
pancreatic tumor9
skin tumor7
soft tissue/muscle tissue tumor15
uterine tumor33
Developmental Stage
TissuesTPM*
adult3
embryoid body14
neonate128
fetus5
juvenile35
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue21.8
adrenal gland17.7
appendix24.8
bone marrow15
cerebral cortex13.2
colon26
duodenum11.3
esophagus34.3
gallbladder22.7
heart muscle15.8
kidney13.6
liver15.7
lung21.1
lymph node39
ovary22.3
pancreas6.3
placenta25.7
prostate19.8
salivary gland13.1
skin21.2
small intestine13.7
spleen24.4
stomach15.8
testis20.1
thyroid gland27.6
urinary bladder33.9
Tissues
TissuesExpression level
adrenal glandHigh
appendixHigh
bone marrowMedium
breastMedium
bronchusHigh
cerebellumMedium
cerebral cortexMedium
cervix, uterineMedium
colonMedium
duodenumMedium
endometrium 1Medium
endometrium 2High
epididymisMedium
esophagusMedium
fallopian tubeMedium
heart muscleLow
hippocampusLow
kidneyHigh
liverMedium
lungHigh
lymph nodeHigh
nasopharynxHigh
oral mucosaMedium
ovaryMedium
pancreasMedium
parathyroid glandHigh
placentaMedium
prostateHigh
rectumMedium
salivary glandMedium
seminal vesicleHigh
skin 1Low
skin 2Low
small intestineLow
soft tissue 1Low
soft tissue 2Medium
spleenLow
stomach 1Medium
stomach 2Medium
testisHigh
thyroid glandHigh
tonsilHigh
urinary bladderHigh
vaginaMedium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600508, gene) Nck adaptor protein 1; NCK1OMIM


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