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> Protein (NX_P16870)
Protein (NX_P16870)
Protein
Gene SymbolCPE to neXtProt (NX_P16870)
DescriptionCarboxypeptidase E
Chromosome4
Location4q32.3 (166282346 ~ 166419472) to Ensembl
Sequene Features : Isoforms 2, Variants 79, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.protein localization to membrane
.cellular protein metabolic process
.insulin processing
  + 5 more...
.cell adhesion molecule binding
.neurexin family protein binding
.zinc ion binding
  + 2 more...
.extracellular exosome
.secretory granule membrane
.transport vesicle membrane
  + 3 more...
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
2 79 2
2014-09-19protein level
2 61 2
2014-05-27protein level
2 61 2
2014-02-25protein level
2 61 2
2013-12-09protein level
2 59 2
2013-11-01protein level
2 55 2
2013-09-12protein level
2 55 2
2013-08-17protein level
2 55 2
2013-07-15protein level
2 36 2
2013-06-11protein level
2 36 2
2013-02-12protein level
2 18 4
2012-12-20protein level
2 18 4
2012-10-30protein level
2 18 4
2012-10-07protein level
2 18 2
2012-08-24protein level
2 18 2
2012-07-28protein level
2 18 2
2012-06-08protein level
2 20 2
2012-05-07protein level
2 16 2
2012-04-10protein level
2 16 2
2012-01-13protein level
2 7 2
2011-12-20protein level
2 7 2
2011-11-11protein level
2 7 2
2011-08-23protein level
2 7 2
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P16870-1
1 22 0 53116.9782
NX_P16870-2
0 22 0 49854.3825
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-711320,EBI-1181405 PRKAA1  
  .negative regulation of glucose import in response to insulin stimulus
.regulation of energy homeostasis
.response to camptothecin
  + 42 more...
.[acetyl-CoA carboxylase] kinase activity
.tau-protein kinase activity
.[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity
  + 7 more...
.AMP-activated protein kinase complex
.apical plasma membrane
.cytosol
  + 4 more...
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue310
adrenal gland91
bone153
brain288
cervix20
connective tissue73
ear1118
embryonic tissue122
eye162
heart122
kidney71
larynx213
liver34
lung119
lymph node11
mammary gland26
mouth15
muscle28
nerve193
ovary9
pancreas1133
parathyroid194
pharynx73
pituitary gland1936
placenta14
prostate105
skin9
stomach20
testis68
thymus12
thyroid128
trachea19
umbilical cord217
uterus17
vascular309
Health State
TissuesTPM*
normal183
breast (mammary gland) tumor42
chondrosarcoma169
gastrointestinal tumor8
germ cell tumor34
glioma130
head and neck tumor89
kidney tumor87
liver tumor52
lung tumor19
non-neoplasia165
ovarian tumor13
pancreatic tumor1057
primitive neuroectodermal tumor of the CNS47
prostate cancer67
retinoblastoma21
soft tissue/muscle tissue tumor15
uterine tumor11
Developmental Stage
TissuesTPM*
adult109
embryoid body228
blastocyst48
neonate96
fetus122
infant42
juvenile107
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue134.1
adrenal gland165.9
appendix26.3
cerebral cortex807
colon61.6
duodenum23.3
esophagus107.8
gallbladder108.2
heart muscle103.2
kidney53.4
liver17.9
lung55.2
lymph node50
ovary125.2
pancreas100.1
placenta5.6
prostate365.4
salivary gland54.9
skin20.1
small intestine30.4
spleen12.2
stomach114.4
testis195.3
thyroid gland220.1
urinary bladder42
Tissues
TissuesExpression level
appendixMedium
bronchusLow
cerebellumMedium
cerebral cortexMedium
colonMedium
duodenumMedium
heart muscleLow
hippocampusHigh
lungLow
pancreasHigh
prostateMedium
rectumMedium
salivary glandLow
small intestineMedium
soft tissue 1Low
stomach 1Medium
stomach 2Medium
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*114855, gene) Carboxypeptidase e; CPEOMIM


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