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> Protein (NX_P16885)
Protein (NX_P16885)
Protein
Gene SymbolPLCG2 to neXtProt (NX_P16885)
Description1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2
Chromosome16
Location16q23.3 (81772702 ~ 81991899) to Ensembl
Sequene Features : Isoforms 1, Variants 209, PTMsto neXtProt Sequence Features
Gene
Ontologies
GO: Biological Process GO: Mulecular Function GO: Cellular Component
.release of sequestered calcium ion into cytosol
.B cell receptor signaling pathway
.T cell receptor signaling pathway
  + 19 more...
.signal transducer activity
.phospholipase C activity
.phosphatidylinositol phospholipase C activity
.extracellular exosome
.plasma membrane
.cytosol
Proteomic Evidences
ReleaseProtein EvidencePrAbIsoformsVariantsPTMs
2015-01-01protein level
1 209 5
2014-09-19protein level
1 150 5
2014-05-27protein level
1 150 6
2014-02-25protein level
1 150 6
2013-12-09protein level
1 112 6
2013-11-01protein level
1 109 6
2013-09-12protein level
1 109 6
2013-08-17protein level
1 109 6
2013-07-15protein level
1 70 6
2013-06-11protein level
1 70 6
2013-02-12protein level
1 35 6
2012-12-20protein level
1 31 6
2012-10-30protein level
1 45 6
2012-10-07protein level
1 45 6
2012-08-24protein level
1 44 6
2012-07-28protein level
1 44 6
2012-06-08protein level
1 52 6
2012-05-07protein level
1 35 5
2012-04-10protein level
1 35 5
2012-01-13protein level
1 27 5
2011-12-20protein level
1 27 5
2011-11-11protein level
1 27 5
2011-08-23protein level
1 27 5
Protein Isoforms
Isoform Ac UGSMw (Da)
NX_P16885-1
60 0 0 147775.7481
: Uniquely mapped peptide
: Gene-specific peptide
: Shared peptide
Interacting Partners
No. Exp. ref. Symbol   PE Pr Ab Di   GO: Biological Process GO: Mulecular Function GO: Cellular Component
1 EBI-617403,EBI-357622 PSMD3  
  .positive regulation of canonical Wnt signaling pathway
.negative regulation of canonical Wnt signaling pathway
.regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
  + 22 more...
.enzyme regulator activity .extracellular exosome
.proteasome accessory complex
.membrane
  + 6 more...
2 EBI-617403,EBI-10696047 FSBP  
  .regulation of transcription, DNA-templated
.transcription, DNA-templated
.identical protein binding .nucleus
3 EBI-617403,EBI-297353 EGFR  
  .cellular response to dexamethasone stimulus
.cellular response to estradiol stimulus
.cellular response to epidermal growth factor stimulus
  + 73 more...
.actin filament binding
.protein heterodimerization activity
.identical protein binding
  + 12 more...
.multivesicular body, internal vesicle lumen
.Shc-EGFR complex
.perinuclear region of cytoplasm
  + 19 more...
4 EBI-617403,EBI-641062 ERBB2  
  .regulation of ERK1 and ERK2 cascade
.positive regulation of epithelial cell proliferation
.oligodendrocyte differentiation
  + 35 more...
.protein dimerization activity
.protein heterodimerization activity
.ErbB-3 class receptor binding
  + 9 more...
.perinuclear region of cytoplasm
.receptor complex
.cytoplasmic vesicle
  + 7 more...
5 EBI-617403,EBI-608057 AR  
  .negative regulation of extrinsic apoptotic signaling pathway
.regulation of establishment of protein localization to plasma membrane
.protein oligomerization
  + 21 more...
.ATPase binding
.protein dimerization activity
.transcription regulatory region DNA binding
  + 14 more...
.protein complex
.cytosol
.cytoplasm
  + 3 more...
6 EBI-617403,EBI-1379503 KIT  
  .melanocyte adhesion
.melanocyte migration
.cellular response to thyroid hormone stimulus
  + 69 more...
.metal ion binding
.protein homodimerization activity
.cytokine binding
  + 5 more...
.mast cell granule
.integral component of membrane
.cytoplasmic side of plasma membrane
  + 5 more...
7 EBI-617403,EBI-617321 EPOR  
  .decidualization
.erythropoietin-mediated signaling pathway
.heart development
  + 2 more...
.identical protein binding
.erythropoietin receptor activity
.integral component of plasma membrane
.extracellular region
8 EBI-617403,EBI-79464 PIK3R1  
  .positive regulation of endoplasmic reticulum unfolded protein response
.positive regulation of establishment of protein localization to plasma membrane
.growth hormone receptor signaling pathway
  + 41 more...
.1-phosphatidylinositol-3-kinase regulator activity
.insulin receptor substrate binding
.insulin binding
  + 9 more...
.membrane
.phosphatidylinositol 3-kinase complex, class IA
.phosphatidylinositol 3-kinase complex
  + 5 more...
9 EBI-617403,EBI-517684 GAB1  
  .interleukin-6-mediated signaling pathway
.labyrinthine layer development
.phosphatidylinositol-mediated signaling
  + 13 more...
.SH3/SH2 adaptor activity
.signal transducer activity
.cytosol
EST expression level of Protein Coding Gene (ref. NCBI UniGene EST)
Body Sites
TissuesTPM*
adipose tissue77
blood24
bone13
brain4
liver4
lymph90
lymph node22
stomach10
Health State
TissuesTPM*
normal3
breast (mammary gland) tumor10
chondrosarcoma24
gastrointestinal tumor8
germ cell tumor7
leukemia31
lymphoma55
non-neoplasia20
Developmental Stage
TissuesTPM*
adult27
neonate64
fetus30
TPM*: Transcripts per million; transcript expression level measured by expression sequence tags.
Expression level of Protein (ref. Human Protein Atlas)
RNA-Seq.
TissuesFPKM
adipose tissue7.8
adrenal gland5.6
appendix41.1
bone marrow24.1
cerebral cortex2.5
colon10.8
duodenum20.7
esophagus7
gallbladder17.9
heart muscle6
kidney24.5
liver13.4
lung12.3
lymph node76.6
ovary1.9
pancreas3.1
placenta18.6
prostate3
salivary gland7.6
skin7.1
small intestine16.2
spleen46.7
stomach12.3
testis3.3
thyroid gland9.9
urinary bladder23.1
Tissues
TissuesExpression level
adrenal glandMedium
appendixHigh
bone marrowHigh
breastMedium
bronchusLow
cerebellumMedium
cerebral cortexMedium
colonHigh
duodenumLow
endometrium 1Low
endometrium 2Low
epididymisMedium
fallopian tubeLow
gallbladderHigh
heart muscleMedium
hippocampusMedium
kidneyMedium
lateral ventricleMedium
lungMedium
lymph nodeHigh
nasopharynxLow
ovaryMedium
placentaMedium
rectumLow
seminal vesicleLow
skeletal muscleMedium
skin 1High
small intestineLow
smooth muscleMedium
soft tissue 2Medium
spleenHigh
stomach 1Low
stomach 2Low
testisMedium
thyroid glandLow
tonsilHigh
urinary bladderLow
Cancer
TumorNumber of patients and Staining levels
breast cancer
carcinoid
cervical cancer
colorectal cancer
endometrial cancer
glioma
head and neck cancer
liver cancer
lung cancer
lymphoma
melanoma
ovarian cancer
pancreatic cancer
prostate cancer
renal cancer
skin cancer
stomach cancer
testis cancer
thyroid cancer
urothelial cancer
RNA-seq colour codes
Highly expressed RNAs (FPKM >50)
Moderately expressed RNAs (50> FPKM >10)
Lower expressed RNAs (10> FPKM >1)
The lowest expressed RNAs (FPKM value of 0 or 1)
Expression level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Staining level colour codes
Highly expressed protein
Moderately expressed protein
Lower expressed protein
Not Detected
Disease
No.Disease DescriptionRef.
1(*600220, gene) Phospholipase c, gamma-2; PLCG2OMIM
2(#614468, phenotype) Familial cold autoinflammatory syndrome 3; FCAS3OMIM
3(#614878, phenotype) Autoinflammation, antibody deficiency, and immune dysregulation, plcg2-associated;OMIM


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